HitPredict

Interactor 1: ITB3 (P05106)
Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)
Gene: ITGB3

Interactor 2: ITAV (P06756)
Integrin alpha-V (Vitronectin receptor) (Vitronectin receptor subunit alpha) (CD antigen CD51) [Cleaved into: Integrin alpha-V heavy chain; Integrin alpha-V light chain]
Gene: ITGAV

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.969

The method score is based on:

Property Details
Experiments 10891446, 11884718, 22178926, 24658351, 1694173, 20639902, 11546839, 15299032, 16099422
Identification Methods affinity chromatography technology, x-ray crystallography, pull down, molecular sieving, solid phase assay, anti bait coimmunoprecipitation, enzyme linked immunosorbent assay
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains EGF_2~Integrin_alpha2, I-EGF_1~Integrin_alpha2, Integrin_alpha~Integrin_b_cyt, Integrin_B_tail~Integrin_alpha2, FG-GAP~Integrin_beta, Integrin_alpha2~Integrin_beta, Integrin_alpha2~PSI_integrin
Common GO terms GO:0001618 - virus receptor activity
GO:0001968 - fibronectin binding
GO:0002020 - protease binding
GO:0005080 - protein kinase C binding
GO:0005178 - integrin binding
and 35 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 788
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024