Interactor 1: KAPCA (P05132)
cAMP-dependent protein kinase catalytic subunit alpha (PKA C-alpha) (EC 2.7.11.11)
Gene: Prkaca

Interactor 2: IPKA (P63248)
cAMP-dependent protein kinase inhibitor alpha (PKI-alpha) (cAMP-dependent protein kinase inhibitor, muscle/brain isoform)
Gene: Pkia

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.73 1.00 0.858

The method score is based on:

Property Details
Experiments 8443157, 26833386, 23458248
Identification Methods x-ray crystallography, isothermal titration calorimetry, nuclear magnetic resonance
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PKI~Pkinase
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0005634 - nucleus
GO:0005737 - cytoplasm
Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 351
Mm

1 76
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024