Protein: TPX2
Targeting protein for Xklp2 (Differentially expressed in cancerous and non-cancerous lung cells 2) (DIL-2) (Hepatocellular carcinoma-associated antigen 519) (Hepatocellular carcinoma-associated antigen 90) (Protein fls353) (Restricted expression proliferation-associated protein 100) (p100)

Gene: TPX2
Organism: Homo sapiens
Interactions: 204
UniProt ID: Q9ULW0

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000922 - spindle pole
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005819 - spindle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

170426

AURKA
Aurora kinase A

13

1

Small-scale

0.983

High

1158204

MK14
Mitogen-activated protein kinase 14

3

2

High-throughput

0.861

High

1025438

CDK6
Cyclin-dependent kinase 6

1

2

Small-scale

0.710

High

636164

CD11B
Cyclin-dependent kinase 11B

1

2

High-throughput

0.691

High

1439396

KC1G1
Casein kinase I isoform gamma-1

1

1

High-throughput

0.691

High

1452828

CDK12
Cyclin-dependent kinase 12

1

3

High-throughput

0.691

High

1461790

KC1G3
Casein kinase I isoform gamma-3

1

1

High-throughput

0.691

High

386359

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

4

4

High-throughput

0.676

High

1063696

GOGA2
Golgin subfamily A member 2

3

3

High-throughput

0.672

High

636904

GSTM3
Glutathione S-transferase Mu 3

3

1

High-throughput

0.667

High

167994

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

4

Small-scale

0.665

High

177958

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

7

Small-scale

0.665

High

1351896

NEK7
Serine/threonine-protein kinase Nek7

1

3

High-throughput

0.665

High

799572

BRCA1
Breast cancer type 1 susceptibility protein

3

3

Small-scale

0.656

High

373476

MYC
Myc proto-oncogene protein

3

3

High-throughput

0.640

High

998940

H31
Histone H3.1

3

3

High-throughput

0.640

High

157978

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.618

High

401691

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.618

High

692156

MARK3
MAP/microtubule affinity-regulating kinase 3

1

2

High-throughput

0.618

High

1116129

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

4

High-throughput

0.618

High

1270552

MARK2
Serine/threonine-protein kinase MARK2

1

2

High-throughput

0.618

High

1391849

AURKB
Aurora kinase B

1

1

Small-scale

0.618

High

1453876

MARK1
Serine/threonine-protein kinase MARK1

1

2

High-throughput

0.618

High

1459829

TBK1
Serine/threonine-protein kinase TBK1

1

7

High-throughput

0.618

High

590020

RFA2
Replication protein A 32 kDa subunit

2

1

High-throughput

0.584

High

981178

H2B1C
Histone H2B type 1-C/E/F/G/I

2

11

High-throughput

0.584

High

347410

BAG2
BAG family molecular chaperone regulator 2

2

0

High-throughput

0.576

High

397207

ESR1
Estrogen receptor

2

6

High-throughput

0.571

High

1309682

ARHGJ
Rho guanine nucleotide exchange factor 19

2

4

High-throughput

0.571

High

129547

MEN1
Menin

2

0

High-throughput

0.559

High

696850

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

High-throughput

0.559

High

699892

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

0

High-throughput

0.559

High

769498

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

211608

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

0

Small-scale

0.549

High

936886

NP1L1
Nucleosome assembly protein 1-like 1

1

1

High-throughput

0.541

High

64584

MP3B2
Microtubule-associated protein 1 light chain 3 beta 2

1

5

High-throughput

0.536

High

187211

PPM1G
Protein phosphatase 1G

1

1

High-throughput

0.536

High

214975

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

2

High-throughput

0.536

High

276355

HMMR
Hyaluronan mediated motility receptor

1

7

Small-scale

0.536

High

487879

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.536

High

502175

H2AZ
Histone H2A.Z

1

5

High-throughput

0.536

High

502590

H2A1
Histone H2A type 1

1

4

High-throughput

0.536

High

601903

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.536

High

854384

KI67
Proliferation marker protein Ki-67

1

5

High-throughput

0.536

High

875829

PRC2A
Protein PRRC2A

1

6

High-throughput

0.536

High

888686

YLPM1
YLP motif-containing protein 1

1

5

High-throughput

0.536

High

1033310

EWS
RNA-binding protein EWS

1

1

High-throughput

0.536

High

1036701

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

1

High-throughput

0.536

High

1086836

BPTF
Nucleosome-remodeling factor subunit BPTF

1

6

High-throughput

0.536

High

1088302

SFSWA
Splicing factor, suppressor of white-apricot homolog

1

3

High-throughput

0.536

High

1105003

PPIG
Peptidyl-prolyl cis-trans isomerase G

1

1

High-throughput

0.536

High

1121760

SAFB2
Scaffold attachment factor B2

1

9

High-throughput

0.536

High

1129392

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

4

High-throughput

0.536

High

1163286

H2B2E
Histone H2B type 2-E

1

11

High-throughput

0.536

High

1250802

MPRIP
Myosin phosphatase Rho-interacting protein

1

2

High-throughput

0.536

High

1350222

PREX1
Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

1

4

High-throughput

0.536

High

1356518

PHF10
PHD finger protein 10

1

2

High-throughput

0.536

High

1365107

PHF3
PHD finger protein 3

1

2

High-throughput

0.536

High

1368811

EZH1
Histone-lysine N-methyltransferase EZH1

1

6

High-throughput

0.536

High

1411104

BUD13
BUD13 homolog

1

4

High-throughput

0.536

High

1413332

DIDO1
Death-inducer obliterator 1

1

8

High-throughput

0.536

High

1429922

SP130
Histone deacetylase complex subunit SAP130

1

4

High-throughput

0.536

High

1430036

NSRP1
Nuclear speckle splicing regulatory protein 1

1

3

High-throughput

0.536

High

1439648

CHM1A
Charged multivesicular body protein 1a

1

1

High-throughput

0.536

High

1449050

HELLS
Lymphoid-specific helicase

1

2

High-throughput

0.536

High

1450212

DCA13
DDB1- and CUL4-associated factor 13

1

2

High-throughput

0.536

High

1451204

SLTM
SAFB-like transcription modulator

1

8

High-throughput

0.536

High

1453797

RAI14
Ankycorbin

1

3

High-throughput

0.536

High

1458932

ZO2
Tight junction protein 2

1

2

High-throughput

0.536

High

1461242

HDAC9
Histone deacetylase 9

1

1

High-throughput

0.536

High

1461782

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

2

High-throughput

0.536

High

1461786

FARP1
FERM, ARHGEF and pleckstrin domain-containing protein 1

1

1

High-throughput

0.536

High

1389090

THA11
THAP domain-containing protein 11

1

0

High-throughput

0.518

High

788264

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

2

High-throughput

0.515

High

336514

SVIL
Supervillin

1

0

High-throughput

0.513

High

612012

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

940200

RRP1
Ribosomal RNA processing protein 1 homolog A

1

0

High-throughput

0.513

High

1054818

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.513

High

1099821

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1101092

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

1252789

RN111
E3 ubiquitin-protein ligase Arkadia

1

0

High-throughput

0.513

High

1270802

DDX46
Probable ATP-dependent RNA helicase DDX46

1

0

High-throughput

0.513

High

1327358

AFAP1
Actin filament-associated protein 1

1

0

High-throughput

0.513

High

1332861

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.513

High

1337501

NGDN
Neuroguidin

1

0

High-throughput

0.513

High

1346573

RP9
Retinitis pigmentosa 9 protein

1

0

High-throughput

0.513

High

1346983

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.513

High

1357102

CATIN
Splicing factor Cactin

1

0

High-throughput

0.513

High

1358222

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.513

High

1389745

RRP36
Ribosomal RNA processing protein 36 homolog

1

0

High-throughput

0.513

High

1394208

LRCH3
DISP complex protein LRCH3

1

0

High-throughput

0.513

High

1404501

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1417833

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.513

High

1438844

NCOA5
Nuclear receptor coactivator 5

1

0

High-throughput

0.513

High

1451169

ARGL1
Arginine and glutamate-rich protein 1

1

0

High-throughput

0.513

High

1451987

CWC25
Pre-mRNA-splicing factor CWC25 homolog

1

0

High-throughput

0.513

High

1461785

UTP11
Probable U3 small nucleolar RNA-associated protein 11

1

0

High-throughput

0.513

High

1461788

PAXB1
PAX3- and PAX7-binding protein 1

1

0

High-throughput

0.513

High

1371770

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.501

High

698069

CALR
Calreticulin

1

0

High-throughput

0.493

High

1142271

CD5R1
Cyclin-dependent kinase 5 activator 1

1

0

High-throughput

0.493

High

318415

MYO1D
Unconventional myosin-Id

1

3

High-throughput

0.489

High

710567

EPHA2
Ephrin type-A receptor 2

1

3

High-throughput

0.489

High

1091731

MYO1E
Unconventional myosin-Ie

1

3

High-throughput

0.489

High

1217851

PR38B
Pre-mRNA-splicing factor 38B

1

3

High-throughput

0.489

High

1388559

RMXL1
RNA binding motif protein, X-linked-like-1

1

3

High-throughput

0.489

High

1461602

NEB1
Neurabin-1

1

5

High-throughput

0.489

High

964510

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

213380

ARHG9
Rho guanine nucleotide exchange factor 9

1

3

High-throughput

0.479

High

216560

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

1

High-throughput

0.479

High

218953

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

247462

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

1

High-throughput

0.479

High

251823

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

1

High-throughput

0.479

High

260606

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.479

High

277851

H2AY
Core histone macro-H2A.1

1

5

High-throughput

0.479

High

331412

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.479

High

355618

NSD2
Histone-lysine N-methyltransferase NSD2

1

6

Small-scale

0.479

High

520448

ANDR
Androgen receptor

1

6

High-throughput

0.479

High

558491

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

594134

NCK1
SH2/SH3 adapter protein NCK1

1

4

High-throughput

0.479

High

607217

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

755026

H2B1B
Histone H2B type 1-B

1

11

High-throughput

0.479

High

786931

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

High-throughput

0.479

High

855802

CRK
Adapter molecule crk

1

6

High-throughput

0.479

High

862547

YAP1
Transcriptional coactivator YAP1

1

3

High-throughput

0.479

High

911158

IMA1
Importin subunit alpha-1

1

3

Small-scale

0.479

High

911430

IMA5
Importin subunit alpha-5

1

3

Small-scale

0.479

High

976659

RB11A
Ras-related protein Rab-11A

1

1

High-throughput

0.479

High

980534

H4
Histone H4

1

1

High-throughput

0.479

High

988026

GRB2
Growth factor receptor-bound protein 2

1

5

High-throughput

0.479

High

995893

ACTC
Actin, alpha cardiac muscle 1

1

2

High-throughput

0.479

High

1017295

H33
Histone H3.3

1

3

High-throughput

0.479

High

1027844

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

3

Small-scale

0.479

High

1060725

SOS2
Son of sevenless homolog 2

1

3

High-throughput

0.479

High

1067831

EP300
Histone acetyltransferase p300

1

6

High-throughput

0.479

High

1096860

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.479

High

1097629

CBX3
Chromobox protein homolog 3

1

1

High-throughput

0.479

High

1108276

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

1121915

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

3

High-throughput

0.479

High

1126664

GRB7
Growth factor receptor-bound protein 7

1

5

Small-scale

0.479

High

1129785

MDC1
Mediator of DNA damage checkpoint protein 1

1

9

High-throughput

0.479

High

1138160

TNIP1
TNFAIP3-interacting protein 1

1

5

High-throughput

0.479

High

1141360

BRD3
Bromodomain-containing protein 3

1

4

High-throughput

0.479

High

1155898

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

High-throughput

0.479

High

1276959

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1313527

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

1314483

SLX4
Structure-specific endonuclease subunit SLX4

1

4

High-throughput

0.479

High

1328568

NGEF
Ephexin-1

1

5

High-throughput

0.479

High

1364303

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

High-throughput

0.479

High

1367576

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

1401447

CIC
Protein capicua homolog

1

5

High-throughput

0.479

High

1416949

KLF16
Krueppel-like factor 16

1

1

High-throughput

0.479

High

1437885

PRD16
Histone-lysine N-methyltransferase PRDM16

1

1

High-throughput

0.479

High

1447429

ANLN
Anillin

1

2

High-throughput

0.479

High

1448062

ARHG4
Rho guanine nucleotide exchange factor 4

1

4

High-throughput

0.479

High

1453546

PD1L1
Programmed cell death 1 ligand 1

1

2

High-throughput

0.479

High

1459294

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1461781

FZR1
Fizzy-related protein homolog

1

2

Small-scale

0.479

High

1461783

ASF1A
Histone chaperone ASF1A

1

1

High-throughput

0.479

High

1461789

NEMO
NF-kappa-B essential modulator

1

4

Small-scale

0.479

High

556417

CADH1
Cadherin-1

1

1

High-throughput

0.470

High

223418

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

655955

TBG1
Tubulin gamma-1 chain

1

0

Small-scale

0.458

High

697291

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

718660

CDC27
Cell division cycle protein 27 homolog

1

0

Small-scale

0.458

High

851701

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.458

High

913616

KIF11
Kinesin-like protein KIF11

1

0

Small-scale

0.458

High

915493

HMGA2
High mobility group protein HMGI-C

1

0

Small-scale

0.458

High

979343

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

1024924

VIGLN
Vigilin

1

0

High-throughput

0.458

High

1026588

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1045901

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1134426

IMB1
Importin subunit beta-1

1

0

Small-scale

0.458

High

1141029

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1156897

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1289717

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1329939

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1352831

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1368205

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

1417516

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

1429885

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1435444

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1452479

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1453045

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1461787

PKHM1
Pleckstrin homology domain-containing family M member 1

1

0

Small-scale

0.458

High

430496

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

538106

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.445

High

1364679

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.445

High

1256074

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

1434217

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

1461687

HECD1
E3 ubiquitin-protein ligase HECTD1

1

4

High-throughput

0.437

High

213274

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.426

High

330370

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.426

High

1057039

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.426

High

1461784

ZDHC9
Palmitoyltransferase ZDHHC9

1

0

High-throughput

0.426

High

142635

IMA3
Importin subunit alpha-3

1

3

High-throughput

0.408

High

887327

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.408

High

890262

TIG1
Retinoic acid receptor responder protein 1

1

0

High-throughput

0.279

Low

899679

AT1A2
Sodium/potassium-transporting ATPase subunit alpha-2

1

0

High-throughput

0.279

Low

1093785

GAGE5
G antigen 5

1

0

High-throughput

0.279

Low

1256761

NKAP1
Uncharacterized protein NKAPD1

1

0

High-throughput

0.279

Low

1400311

CC85A
Coiled-coil domain-containing protein 85A

1

0

High-throughput

0.279

Low

1273311

CHST3
Carbohydrate sulfotransferase 3

1

0

High-throughput

0.249

Low

1461427

PNMA2
Paraneoplastic antigen Ma2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025