HitPredict

Interactor 1: FGF1 (P05230)
Fibroblast growth factor 1 (FGF-1) (Acidic fibroblast growth factor) (aFGF) (Endothelial cell growth factor) (ECGF) (Heparin-binding growth factor 1) (HBGF-1)
Gene: FGF1

Interactor 2: FGFR3 (P22607)
Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333)
Gene: FGFR3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.963

Property	Details
Experiments	22955284, 8576175, 10574949, 22244757, 9045692, 14613973, 14732692
Identification Methods	pull down, surface plasmon resonance, coimmunoprecipitation, x-ray crystallography
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	FGF~I-set, FGF~Ig_3
Common GO terms	GO:0005576 - extracellular region GO:0008284 - positive regulation of cell population proliferation GO:0008543 - fibroblast growth factor receptor signaling pathway GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 155 Hs			1 806
+	Hs
		609185 FGF9_HUMAN (11-155): 6.58e-67: 203: 35.85		FGFR3_HUMAN (10-806): 0: 819: 100.00
+	Hs
		601113 FGF7_HUMAN (13-153): 1.87e-65: 199: 35.66		FGFR3_HUMAN (10-806): 0: 819: 100.00
+	Hs
		447022 FGF2_HUMAN (1-154): 7.49e-63: 196: 54.14		FGFR3_HUMAN (10-806): 0: 819: 100.00
+	Mm
		867550 FGF9_MOUSE (11-155): 7.67e-67: 203: 35.85		FGFR3_MOUSE (1-806): 0: 793: 92.32
+	Rn
		896711 FGF1_RAT (1-155): 1.38e-73: 218: 95.48		Q63237_RAT (7-413): 2.16e-139: 421: 52.98
+	Hs
		399128 FGF1_HUMAN (1-155): 2.95e-74: 220: 100.00		FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32
+	Hs
		399155 FGF1_HUMAN (1-155): 2.95e-74: 220: 100.00		Q8NI16_HUMAN (1-114): 2.21e-12: 72.8: 17.69
+	Hs
		399132 FGF1_HUMAN (1-155): 2.95e-74: 220: 100.00		FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56
+	Hs
		399133 FGF1_HUMAN (1-155): 2.95e-74: 220: 100.00		FGFR4_HUMAN (1-130): 1.18e-11: 70.5: 19.31
+	Hs
		507874 FGF9_HUMAN (11-155): 6.58e-67: 203: 35.85		FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32
+	Mm
		555263 FGF9_MOUSE (11-155): 7.67e-67: 203: 35.85		FGFR1_MOUSE (1-114): 2.09e-14: 79.4: 18.32
+	Hs
		181657 FGF10_HUMAN (14-154): 5.14e-66: 201: 32.87		FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32
+	Hs
		447013 FGF2_HUMAN (1-154): 7.49e-63: 196: 54.14		FGFR1_HUMAN (1-114): 1.97e-14: 79.4: 18.32
+	Hs
		601468 FGF9_HUMAN (11-155): 6.58e-67: 203: 35.85		FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56
+	Mm
		549545 FGF2_MOUSE (1-154): 9.1e-64: 194: 53.21		FGFR1_MOUSE (1-114): 2.09e-14: 79.4: 18.32
+	Hs
		181659 FGF10_HUMAN (14-154): 5.14e-66: 201: 32.87		FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56
+	Hs
		601112 FGF7_HUMAN (13-153): 1.87e-65: 199: 35.66		FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56
+	Hs
		447019 FGF2_HUMAN (1-154): 7.49e-63: 196: 54.14		FGFR2_HUMAN (1-114): 9.04e-12: 70.9: 17.56
+	Hs
		447021 FGF2_HUMAN (1-154): 7.49e-63: 196: 54.14		FGFR4_HUMAN (1-130): 1.18e-11: 70.5: 19.31
+	Mm
		549546 FGF2_MOUSE (1-154): 9.1e-64: 194: 53.21		FGFR2_MOUSE (1-114): 2.5e-11: 69.3: 16.79