Protein: DDB1
DNA damage-binding protein 1 (DDB p127 subunit) (Damage-specific DNA-binding protein 1) (UV-damaged DNA-binding factor)

Gene: DDB1
Organism: Mus musculus
Interactions: 124
UniProt ID: Q3U1J4

Gene Ontology (top 5):
GO:0003684 - damaged DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

58993

CUL4B
Cullin-4B

4

18

Small-scale

0.873

High

1189314

CUL4A
Cullin-4A

4

18

Small-scale

0.867

High

1189800

WDTC1
WD and tetratricopeptide repeats protein 1

2

20

Small-scale

0.754

High

1189832

DDB2
DNA damage-binding protein 2

2

20

Small-scale

0.754

High

1189820

DCAF8
DDB1- and CUL4-associated factor 8

2

20

Small-scale

0.737

High

59424

DCA10
DDB1- and CUL4-associated factor 10

1

20

Small-scale

0.618

High

97780

SET1A
Histone-lysine N-methyltransferase SETD1A

1

7

Small-scale

0.618

High

964787

DCAF7
DDB1- and CUL4-associated factor 7

1

18

Small-scale

0.618

High

1189778

WDR81
WD repeat-containing protein 81

1

12

Small-scale

0.618

High

1189781

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

5

High-throughput

0.618

High

1189786

DCA15
DDB1- and CUL4-associated factor 15

1

1

Small-scale

0.618

High

1189789

WDFY3
WD repeat and FYVE domain-containing protein 3

1

15

Small-scale

0.618

High

1189793

DCAF5
DDB1- and CUL4-associated factor 5

1

20

Small-scale

0.618

High

1189801

WDR82
WD repeat-containing protein 82

1

16

Small-scale

0.618

High

1189804

WDR48
WD repeat-containing protein 48

1

14

Small-scale

0.618

High

1189809

A16L1
Autophagy-related protein 16-1

1

12

High-throughput

0.618

High

1189812

WDR26
WD repeat-containing protein 26

1

13

Small-scale

0.618

High

1189827

DCA11
DDB1- and CUL4-associated factor 11

1

20

Small-scale

0.618

High

1189828

BRWD1
Bromodomain and WD repeat-containing protein 1

1

18

Small-scale

0.618

High

1189829

EED
Polycomb protein EED

1

17

High-throughput

0.618

High

1189833

CDK9
Cyclin-dependent kinase 9

1

4

Small-scale

0.618

High

1189841

DCAF6
DDB1- and CUL4-associated factor 6

1

20

Small-scale

0.618

High

1189843

SKI8
Superkiller complex protein 8

1

18

Small-scale

0.618

High

1189851

WDR46
WD repeat-containing protein 46

1

19

Small-scale

0.618

High

1189788

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

Small-scale

0.586

High

1189821

WDR74
WD repeat-containing protein 74

1

0

Small-scale

0.586

High

1189795

DCAF1
DDB1- and CUL4-associated factor 1

2

12

Small-scale

0.584

High

59355

BRWD3
Bromodomain and WD repeat-containing protein 3

1

20

Small-scale

0.553

High

108294

G3X934
WD repeat-containing protein 70

1

12

Small-scale

0.553

High

312090

WDR1
WD repeat-containing protein 1

1

11

Small-scale

0.553

High

1189792

WDR91
WD repeat-containing protein 91

1

20

Small-scale

0.553

High

1189810

WDR59
GATOR2 complex protein WDR59

1

20

Small-scale

0.553

High

1189840

Q9DAD3
WD repeat and FYVE domain containing 1

1

1

Small-scale

0.553

High

629257

PO5F1
POU domain, class 5, transcription factor 1

1

2

High-throughput

0.536

High

1189799

MYOME
Myomegalin

1

2

High-throughput

0.536

High

1189807

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

1189830

TRPM7
Transient receptor potential cation channel subfamily M member 7

1

0

Small-scale

0.513

High

148276

CLOCK
Circadian locomoter output cycles protein kaput

1

7

Small-scale

0.500

High

59236

MED14
Mediator of RNA polymerase II transcription subunit 14

1

1

Small-scale

0.479

High

59310

MED12
Mediator of RNA polymerase II transcription subunit 12

1

10

Small-scale

0.479

High

74278

EP300
Histone acetyltransferase p300

1

9

Small-scale

0.479

High

98093

SETD2
Histone-lysine N-methyltransferase SETD2

1

4

Small-scale

0.479

High

107069

F8VPR5
histone acetyltransferase

1

8

Small-scale

0.479

High

147785

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

5

High-throughput

0.479

High

148685

HDAC1
Histone deacetylase 1

1

9

Small-scale

0.479

High

382476

P53
Cellular tumor antigen p53

1

3

Small-scale

0.479

High

476222

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

3

Small-scale

0.479

High

533451

H2B1M
Histone H2B type 1-M

1

5

Small-scale

0.479

High

568885

DNMT1
DNA

1

4

Small-scale

0.479

High

586403

H12
Histone H1.2

1

5

Small-scale

0.479

High

654172

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

1

Small-scale

0.479

High

837020

ELK1
ETS domain-containing protein Elk-1

1

5

Small-scale

0.479

High

846990

H14
Histone H1.4

1

5

Small-scale

0.479

High

847015

H11
Histone H1.1

1

5

Small-scale

0.479

High

847027

H15
Histone H1.5

1

5

Small-scale

0.479

High

872986

SOX2
Transcription factor SOX-2

1

6

Small-scale

0.479

High

999998

HDAC2
Histone deacetylase 2

1

8

Small-scale

0.479

High

1021772

SMRC1
SWI/SNF complex subunit SMARCC1

1

3

Small-scale

0.479

High

1188072

STING
Stimulator of interferon genes protein

1

1

High-throughput

0.479

High

1189426

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

5

Small-scale

0.479

High

1189623

DCA17
DDB1- and CUL4-associated factor 17

1

1

Small-scale

0.479

High

1189777

WDR19
WD repeat-containing protein 19

1

5

Small-scale

0.479

High

1189780

SPT6H
Transcription elongation factor SPT6

1

3

Small-scale

0.479

High

1189782

H2A2C
Histone H2A type 2-C

1

2

Small-scale

0.479

High

1189783

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

Small-scale

0.479

High

1189784

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

4

Small-scale

0.479

High

1189787

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

4

Small-scale

0.479

High

1189790

PF21A
PHD finger protein 21A

1

4

Small-scale

0.479

High

1189791

KDM1A
Lysine-specific histone demethylase 1A

1

2

Small-scale

0.479

High

1189794

PHF8
Histone lysine demethylase PHF8

1

1

Small-scale

0.479

High

1189796

TAF1
Transcription initiation factor TFIID subunit 1

1

14

Small-scale

0.479

High

1189797

FACD2
Fanconi anemia group D2 protein homolog

1

5

High-throughput

0.479

High

1189802

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

2

High-throughput

0.479

High

1189803

DCA12
DDB1- and CUL4-associated factor 12

1

2

Small-scale

0.479

High

1189805

WDR3
WD repeat-containing protein 3

1

11

Small-scale

0.479

High

1189811

HDAC7
Histone deacetylase 7

1

10

Small-scale

0.479

High

1189813

H2AW
Core histone macro-H2A.2

1

6

Small-scale

0.479

High

1189816

KDM1B
Lysine-specific histone demethylase 1B

1

2

Small-scale

0.479

High

1189823

ELF5
ETS-related transcription factor Elf-5

1

5

High-throughput

0.479

High

1189824

TAF9
Transcription initiation factor TFIID subunit 9

1

2

Small-scale

0.479

High

1189825

EGLN3
Prolyl hydroxylase EGLN3

1

1

Small-scale

0.479

High

1189826

IF4A3
Eukaryotic initiation factor 4A-III

1

3

Small-scale

0.479

High

1189831

MED1
Mediator of RNA polymerase II transcription subunit 1

1

3

Small-scale

0.479

High

1189835

Q99K94
Signal transducer and activator of transcription

1

1

Small-scale

0.479

High

1189838

PHF6
PHD finger protein 6

1

2

Small-scale

0.479

High

1189846

CCNT1
Cyclin-T1

1

4

Small-scale

0.479

High

1189847

H2AY
Core histone macro-H2A.1

1

6

Small-scale

0.479

High

1189848

FZR1
Fizzy-related protein homolog

1

13

High-throughput

0.479

High

1189849

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

7

Small-scale

0.479

High

1189850

CARM1
Histone-arginine methyltransferase CARM1

1

3

Small-scale

0.479

High

1189853

PHF1
PHD finger protein 1

1

1

Small-scale

0.479

High

1189854

HDAC6
Protein deacetylase HDAC6

1

11

Small-scale

0.479

High

98209

E9Q7C1
Mediator of RNA polymerase II transcription subunit 15

1

0

Small-scale

0.458

High

266976

TF2H4
General transcription factor IIH subunit 4

1

0

Small-scale

0.458

High

1189785

SMRD3
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3

1

0

Small-scale

0.458

High

1189798

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

Small-scale

0.458

High

1189814

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

Small-scale

0.458

High

1189817

WDR11
WD repeat-containing protein 11

1

0

Small-scale

0.458

High

1189818

PAF1
RNA polymerase II-associated factor 1 homolog

1

0

Small-scale

0.458

High

1189822

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

Small-scale

0.458

High

1189834

MED24
Mediator of RNA polymerase II transcription subunit 24

1

0

Small-scale

0.458

High

1189837

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

Small-scale

0.458

High

1189839

MED8
Mediator of RNA polymerase II transcription subunit 8

1

0

Small-scale

0.458

High

1189844

GTF2I
General transcription factor II-I

1

0

Small-scale

0.458

High

1189845

TF2H2
General transcription factor IIH subunit 2

1

0

Small-scale

0.458

High

1189852

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

Small-scale

0.458

High

651523

CBL
E3 ubiquitin-protein ligase CBL

1

3

High-throughput

0.445

High

984048

RBX1
E3 ubiquitin-protein ligase RBX1

1

2

High-throughput

0.445

High

1021864

CRY1
Cryptochrome-1

1

2

Small-scale

0.445

High

1182827

TRI63
E3 ubiquitin-protein ligase TRIM63

1

5

High-throughput

0.445

High

1189815

FTM
Protein fantom

1

3

High-throughput

0.445

High

1189842

XPO7
Exportin-7

1

1

High-throughput

0.445

High

398396

CFAD
Complement factor D

1

2

High-throughput

0.437

High

954045

IF4A1
Eukaryotic initiation factor 4A-I

1

3

Small-scale

0.437

High

1188029

Q3TA68
WD repeat domain 36

1

10

Small-scale

0.437

High

1189806

WDR35
WD repeat-containing protein 35

1

6

Small-scale

0.437

High

1189819

FNDC5
Fibronectin type III domain-containing protein 5

1

2

High-throughput

0.437

High

1189836

Q99LF7
DDB1- and CUL4-associated factor 4

1

3

Small-scale

0.437

High

915579

HMGA2
High mobility group protein HMGI-C

1

0

High-throughput

0.426

High

1189779

DJC11
DnaJ homolog subfamily C member 11

1

1

Small-scale

0.407

High

551429

A4
Amyloid-beta precursor protein

1

0

Small-scale

0.391

High

478513

ITB1
Integrin beta-1

1

0

High-throughput

0.261

Low

148429

ELL
RNA polymerase II elongation factor ELL

1

0

Small-scale

0.249

Low

1189808

ORAI1
Calcium release-activated calcium channel protein 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025