Interactor 1: IL6 (P05231)
Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2)
Gene: IL6

Interactor 2: IL6RB (P40189)
Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (CDw130) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
Gene: IL6ST

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.71 1.00 0.845

The method score is based on:

Property Details
Experiments 11251120, 7744001, 15895091
Identification Methods x-ray crystallography, biophysical, chromatography technology, electron microscopy
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains IL6~fn3, IL6~IL6Ra-bind
Common GO terms GO:0002675 - positive regulation of acute inflammatory response
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005896 - interleukin-6 receptor complex
GO:0008284 - positive regulation of cell population proliferation
and 9 others

more...

Homologous interactions 1

Homologous interactions

Color coding for hit scores

1 212
Hs

1 918
+ Mm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024