HitPredict

Interactor 1: JUN (P05412)
Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39)
Gene: JUN

Interactor 2: MK08 (P45983)
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
Gene: MAPK8

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.99 0.60 0.773

The method score is based on:

Property Details
Experiments 9032244, 10398438, 8137421, 12052834, 8586671, 16983342, 14701799, 8001819, 11907583, 14557262, 12832416, 15289320, 10987838, 25098452, 10464310, 10908726, 12149229, 22904686, 15143066, 9990010 and 62 others

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Identification Methods affinity chromatography technology, pull down, enzymatic study, two hybrid, biophysical, protein kinase assay, in-gel kinase assay, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0019899 - enzyme binding
GO:0034614 - cellular response to reactive oxygen species
GO:0043065 - positive regulation of apoptotic process
and 1 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 331
Hs

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Last updated: 15 Jul 2024