Protein: QPCT
Glutaminyl-peptide cyclotransferase (EC 2.3.2.5) (Glutaminyl cyclase) (QC) (sQC) (Glutaminyl-tRNA cyclotransferase) (Glutamyl cyclase) (EC)

Gene: QPCT
Organism: Homo sapiens
Interactions: 43
UniProt ID: Q16769

Gene Ontology (top 5):
GO:0005576 - extracellular region
GO:0008270 - zinc ion binding
GO:0016603 - glutaminyl-peptide cyclotransferase activity
GO:0017186 - peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
GO:0035580 - specific granule lumen

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

920700

NUBP1
Cytosolic Fe-S cluster assembly factor NUBP1

3

1

High-throughput

0.609

High

1162747

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

3

1

High-throughput

0.609

High

486698

FGR
Tyrosine-protein kinase Fgr

2

0

High-throughput

0.547

High

1113221

CUL3
Cullin-3

1

6

High-throughput

0.536

High

1115220

CUL4B
Cullin-4B

1

6

High-throughput

0.536

High

1154838

NEDD8
Ubiquitin-like protein NEDD8

1

1

High-throughput

0.536

High

1162727

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

1162732

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.513

High

1112515

CUL1
Cullin-1

1

6

High-throughput

0.489

High

1112856

CUL2
Cullin-2

1

6

High-throughput

0.489

High

1114853

CUL4A
Cullin-4A

1

6

High-throughput

0.489

High

1162731

CUL5
Cullin-5

1

6

High-throughput

0.489

High

335137

ARI2
E3 ubiquitin-protein ligase ARIH2

1

1

High-throughput

0.479

High

350023

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

521367

ARAF
Serine/threonine-protein kinase A-Raf

1

1

High-throughput

0.479

High

1162742

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

136905

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

377587

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

507212

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

0

High-throughput

0.458

High

1162738

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

0

High-throughput

0.458

High

970586

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

1162734

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.437

High

1162745

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.437

High

1162746

ST38L
Serine/threonine-protein kinase 38-like

1

1

High-throughput

0.437

High

1162736

DHRS4
Dehydrogenase/reductase SDR family member 4

3

0

High-throughput

0.347

High

1162740

ELP3
Elongator complex protein 3

3

0

High-throughput

0.347

High

1162728

FRAS1
Extracellular matrix organizing protein FRAS1

3

0

High-throughput

0.335

High

1162743

UBQL2
Ubiquilin-2

2

0

High-throughput

0.316

High

374629

RASH
GTPase HRas

1

0

Small-scale

0.292

High

563837

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.279

Low

909015

NEK4
Serine/threonine-protein kinase Nek4

1

0

High-throughput

0.279

Low

1162729

KMT5C
Histone-lysine N-methyltransferase KMT5C

1

0

High-throughput

0.279

Low

1162730

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.279

Low

1162733

DCNL1
DCN1-like protein 1

1

0

High-throughput

0.279

Low

1162739

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.279

Low

1162741

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.279

Low

1162744

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.279

Low

248304

HBP1
HMG box-containing protein 1

1

0

High-throughput

0.249

Low

935520

MFAP1
Microfibrillar-associated protein 1

1

0

High-throughput

0.249

Low

1162725

UBAP2
Ubiquitin-associated protein 2

1

0

High-throughput

0.249

Low

1162735

NP1L5
Nucleosome assembly protein 1-like 5

1

0

High-throughput

0.249

Low

1162726

ELP2
Elongator complex protein 2

1

0

High-throughput

0.232

Low

1162737

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025