HitPredict

Interactor 1: RPC4 (P05423)
DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4) (DNA-directed RNA polymerase III subunit D) (Protein BN51) (RNA polymerase III 47 kDa subunit) (RPC53 homolog)
Gene: POLR3D

Interactor 2: RPC5 (Q9NVU0)
DNA-directed RNA polymerase III subunit RPC5 (RNA polymerase III subunit C5) (DNA-directed RNA polymerase III 80 kDa polypeptide)
Gene: POLR3E

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.970

Property	Details
Experiments	26496610, 12391170, 35271311, 26186194, 28514442, 24981860, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	RNA_pol_Rpc4~RPC5
Common GO terms	GO:0005654 - nucleoplasm GO:0005666 - RNA polymerase III complex GO:0005829 - cytosol GO:0042797 - tRNA transcription by RNA polymerase III GO:0045087 - innate immune response and 1 others more... GO:0051607 - defense response to virus
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 398 Hs			1 708
+	Dm
		1249266 Q8SYM9_DROME (2-396): 2.67e-93: 287: 23.01		Q9VP85_DROME (4-425): 0: 574: 32.51
+	Dm
		1124404 Q8SYM9_DROME (2-396): 2.67e-93: 287: 23.01		Q5BI58_DROME (12-425): 0: 560: 31.26
+	Sc
		631661 RPC4_YEAST (38-389): 3.78e-81: 256: 19.24		RPC5_YEAST (8-210): 2.28e-56: 195: 22.33
+	Sp
		252193 RPC4_SCHPO (163-389): 4.84e-62: 204: 21.92		RPC5_SCHPO (4-231): 2.59e-70: 231: 26.27