Protein: CYTA
Cystatin-A (Cystatin-AS) (Stefin-A) [Cleaved into: Cystatin-A, N-terminally processed]

Gene: CYTA, CSTA
Organism: Homo sapiens
Interactions: 156
UniProt ID: P01040

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0002020 - protease binding
GO:0004869 - cysteine-type endopeptidase inhibitor activity
GO:0005615 - extracellular space
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

370262

CATB
Cathepsin B

4

7

Small-scale

0.896

High

370261

CATL1
Procathepsin L

3

6

Small-scale

0.857

High

370264

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

2

6

Small-scale

0.776

High

261580

CATL2
Cathepsin L2

1

4

High-throughput

0.691

High

370279

CATO
Cathepsin O

1

8

High-throughput

0.691

High

370282

CATC
Dipeptidyl peptidase 1

1

9

High-throughput

0.691

High

370372

CATF
Cathepsin F

1

8

High-throughput

0.691

High

370250

CYTA
Cystatin-A

1

1

Small-scale

0.647

High

370265

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.611

High

370298

CUL2
Cullin-2

2

2

High-throughput

0.611

High

370306

ZIC1
Zinc finger protein ZIC 1

2

0

High-throughput

0.602

High

370352

LGMN
Legumain

1

1

Small-scale

0.575

High

370289

RHG04
Rho GTPase-activating protein 4

2

1

High-throughput

0.571

High

370351

PKH4B
Pleckstrin homology domain-containing family G member 4B

2

1

High-throughput

0.571

High

370358

MLP3B
Microtubule-associated protein 1 light chain 3 beta

2

4

High-throughput

0.571

High

370268

DESP
Desmoplakin

2

0

Small-scale

0.569

High

64843

RCCD1
RCC1 domain-containing protein 1

1

1

High-throughput

0.536

High

66476

RASFA
Ras association domain-containing protein 10

1

1

High-throughput

0.536

High

221016

HAIR
Lysine-specific demethylase hairless

1

1

High-throughput

0.536

High

273387

KDM4A
Lysine-specific demethylase 4A

1

1

High-throughput

0.536

High

296868

RASF9
Ras association domain-containing protein 9

1

1

High-throughput

0.536

High

370299

CUL4B
Cullin-4B

1

2

High-throughput

0.536

High

370321

KDM3B
Lysine-specific demethylase 3B

1

1

High-throughput

0.536

High

370332

HORN
Hornerin

1

2

High-throughput

0.536

High

370342

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

1

High-throughput

0.536

High

370361

KDM4C
Lysine-specific demethylase 4C

1

1

High-throughput

0.536

High

370368

ASF1B
Histone chaperone ASF1B

1

1

High-throughput

0.536

High

370373

BAZ2A
Bromodomain adjacent to zinc finger domain protein 2A

1

1

High-throughput

0.536

High

370376

ASF1A
Histone chaperone ASF1A

1

1

High-throughput

0.536

High

370338

ARG39
Rho guanine nucleotide exchange factor 39

2

2

High-throughput

0.521

High

370324

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.515

High

135762

RTCA
RNA 3'-terminal phosphate cyclase

1

0

High-throughput

0.513

High

168167

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.513

High

185332

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.513

High

253470

ANM3
Protein arginine N-methyltransferase 3

1

0

High-throughput

0.513

High

352660

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.513

High

362541

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.513

High

370277

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.513

High

370280

NASP
Nuclear autoantigenic sperm protein

1

0

High-throughput

0.513

High

370293

RAD51
DNA repair protein RAD51 homolog 1

1

0

High-throughput

0.513

High

370301

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.513

High

370305

OASL
2'-5'-oligoadenylate synthase-like protein

1

0

High-throughput

0.513

High

370314

CYTSA
Cytospin-A

1

0

High-throughput

0.513

High

370317

FOXR1
Forkhead box protein R1

1

0

High-throughput

0.513

High

370322

APTX
Aprataxin

1

0

High-throughput

0.513

High

370323

PIWL4
Piwi-like protein 4

1

0

High-throughput

0.513

High

370327

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

0

High-throughput

0.513

High

370349

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

0

High-throughput

0.513

High

370353

EPAS1
Endothelial PAS domain-containing protein 1

1

0

High-throughput

0.513

High

370354

SENP7
Sentrin-specific protease 7

1

0

High-throughput

0.513

High

370362

MOB1A
MOB kinase activator 1A

1

0

High-throughput

0.513

High

370374

PHF8
Histone lysine demethylase PHF8

1

0

High-throughput

0.513

High

370333

ZDH17
Palmitoyltransferase ZDHHC17

1

1

High-throughput

0.494

High

370255

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.493

High

370274

GRN
Progranulin

1

0

High-throughput

0.493

High

370360

VPS11
Vacuolar protein sorting-associated protein 11 homolog

1

1

High-throughput

0.489

High

370253

K2C1
Keratin, type II cytoskeletal 1

1

0

Small-scale

0.480

High

370260

INVO
Involucrin

1

0

Small-scale

0.480

High

370270

ELAF
Elafin

1

0

Small-scale

0.480

High

370272

LORI
Loricrin

1

0

Small-scale

0.480

High

370381

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

0

Small-scale

0.480

High

238338

RAD21
Double-strand-break repair protein rad21 homolog

1

1

High-throughput

0.479

High

370251

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

370257

S10A8
Protein S100-A8

1

2

High-throughput

0.479

High

370258

S10A9
Protein S100-A9

1

2

High-throughput

0.479

High

370269

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

370275

PML
Protein PML

1

1

High-throughput

0.479

High

370278

VHL
von Hippel-Lindau disease tumor suppressor

1

1

High-throughput

0.479

High

370281

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

370297

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

370308

LARP7
La-related protein 7

1

1

High-throughput

0.479

High

370319

UBN2
Ubinuclein-2

1

1

High-throughput

0.479

High

370325

FGD2
FYVE, RhoGEF and PH domain-containing protein 2

1

1

High-throughput

0.479

High

370328

TLK2
Serine/threonine-protein kinase tousled-like 2

1

2

High-throughput

0.479

High

370329

ZN598
E3 ubiquitin-protein ligase ZNF598

1

1

High-throughput

0.479

High

370330

MET23
Histone-arginine methyltransferase METTL23

1

1

High-throughput

0.479

High

370336

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.479

High

370340

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.479

High

370344

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

370355

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

370363

UBN1
Ubinuclein-1

1

1

High-throughput

0.479

High

370371

RHG20
Rho GTPase-activating protein 20

1

3

High-throughput

0.479

High

370380

LOXL2
Lysyl oxidase homolog 2

1

2

High-throughput

0.479

High

209418

SERA
D-3-phosphoglycerate dehydrogenase

1

0

Small-scale

0.458

High

293010

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

302295

RNF8
E3 ubiquitin-protein ligase RNF8

1

0

High-throughput

0.458

High

342711

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

370252

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

370254

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

370256

ARGI1
Arginase-1

1

0

High-throughput

0.458

High

370259

ANXA2
Annexin A2

1

0

High-throughput

0.458

High

370263

MSMB
Beta-microseminoprotein

1

0

High-throughput

0.458

High

370266

PLAK
Junction plakoglobin

1

0

High-throughput

0.458

High

370267

TFE2
Transcription factor E2-alpha

1

0

High-throughput

0.458

High

370273

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

370276

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

0

Small-scale

0.458

High

370283

HIRA
Protein HIRA

1

0

High-throughput

0.458

High

370286

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

370287

TBA1B
Tubulin alpha-1B chain

1

0

High-throughput

0.458

High

370290

VIGLN
Vigilin

1

0

High-throughput

0.458

High

370291

FABP5
Fatty acid-binding protein 5

1

0

High-throughput

0.458

High

370292

DSG1
Desmoglein-1

1

0

High-throughput

0.458

High

370295

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

370296

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

370300

DX39B
Spliceosome RNA helicase DDX39B

1

0

High-throughput

0.458

High

370302

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.458

High

370303

ELOC
Elongin-C

1

0

High-throughput

0.458

High

370304

ELOB
Elongin-B

1

0

High-throughput

0.458

High

370307

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

370310

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.458

High

370311

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

370313

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

370318

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

370331

CEP57
Centrosomal protein of 57 kDa

1

0

High-throughput

0.458

High

370335

CDAN1
Codanin-1

1

0

High-throughput

0.458

High

370343

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

0

High-throughput

0.458

High

370345

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.458

High

370348

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

0

Small-scale

0.458

High

370350

SPB12
Serpin B12

1

0

High-throughput

0.458

High

370356

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.458

High

370357

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

370359

DDX24
ATP-dependent RNA helicase DDX24

1

0

High-throughput

0.458

High

370364

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

370365

ANLN
Anillin

1

0

High-throughput

0.458

High

370369

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

370370

CALL5
Calmodulin-like protein 5

1

0

High-throughput

0.458

High

370377

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

0

Small-scale

0.458

High

370378

CDIN1
CDAN1-interacting nuclease 1

1

0

High-throughput

0.458

High

370382

CABIN
Calcineurin-binding protein cabin-1

1

0

High-throughput

0.458

High

370285

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

4

High-throughput

0.445

High

370294

LG3BP
Galectin-3-binding protein

1

2

High-throughput

0.445

High

370309

ODFP2
Outer dense fiber protein 2

1

1

High-throughput

0.445

High

370271

PTN
Pleiotrophin

1

0

High-throughput

0.438

High

370346

KISSR
KiSS-1 receptor

1

1

Small-scale

0.437

High

370284

CD81
CD81 antigen

1

0

Small-scale

0.426

High

370312

RNLS
Renalase

1

0

Small-scale

0.426

High

370334

SULF2
Extracellular sulfatase Sulf-2

1

0

High-throughput

0.426

High

370339

POC5
Centrosomal protein POC5

1

0

Small-scale

0.426

High

370341

CE192
Centrosomal protein of 192 kDa

1

0

High-throughput

0.426

High

370383

S4A4
Electrogenic sodium bicarbonate cotransporter 1

1

0

High-throughput

0.426

High

370315

Z518A
Zinc finger protein 518A

1

0

High-throughput

0.279

Low

370320

UBP53
Ubiquitin carboxyl-terminal hydrolase 53

1

0

High-throughput

0.279

Low

370337

PARP8
Protein mono-ADP-ribosyltransferase PARP8

1

0

High-throughput

0.279

Low

370347

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.279

Low

370366

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.279

Low

370375

SCML2
Sex comb on midleg-like protein 2

1

0

High-throughput

0.279

Low

109356

G5E9A7
DM1 locus, WD repeat containing

1

0

High-throughput

0.268

Low

301292

WFS1
Wolframin

1

0

High-throughput

0.268

Low

370379

RNF11
RING finger protein 11

1

0

High-throughput

0.268

Low

105065

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

370288

DCD
Dermcidin

1

0

High-throughput

0.249

Low

370316

TECT3
Tectonic-3

1

0

High-throughput

0.249

Low

370326

CLC14
C-type lectin domain family 14 member A

1

0

Small-scale

0.249

Low

370367

S38A7
Sodium-coupled neutral amino acid transporter 7

1

0

High-throughput

0.249

Low

87290

OSCRI
SCRIB overlapping open reading frame protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025