HitPredict

Interactor 1: LA (P05455)
Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B)
Gene: SSB

Interactor 2: PUF60 (Q9UHX1)
Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1)
Gene: PUF60

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.802

Property	Details
Experiments	17353931, 33961781
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	La~RRM_1, RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 408 Hs			1 559
+	Hs
		403225 LA_HUMAN (1-408): 4.97e-104: 315: 100.00		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		1116608 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		PUF60_HUMAN (1-559): 2.1e-103: 324: 100.00
+	Hs
		1054362 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		403212 LA_HUMAN (1-408): 4.97e-104: 315: 100.00		PABP4_HUMAN (457-550): 1.89e-10: 65.7: 10.64
+	Hs
		474019 PAB4L_HUMAN (69-333): 1.17e-44: 160: 15.30		ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80
+	Hs
		474034 PAB4L_HUMAN (69-333): 1.17e-44: 160: 15.30		PABP5_HUMAN (133-308): 3.43e-45: 165: 23.86
+	At
		285478 LRP6B_ARATH (12-258): 6.05e-55: 191: 19.48		PABP8_ARATH (470-559): 7.04e-20: 95.4: 15.56
+	At
		285476 LRP6B_ARATH (12-258): 6.05e-55: 191: 19.48		PABP2_ARATH (452-559): 1.38e-17: 88: 13.89
+	At
		790116 LRP6C_ARATH (11-202): 1.42e-42: 156: 20.59		PABP2_ARATH (452-559): 1.38e-17: 88: 13.89
+	Zm
		8143 A0A1D6ELH4_MAIZE (32-322): 1.15e-44: 165: 13.81		A0A1D6ELH4_MAIZE (2-130): 8.57e-11: 66.9: 8.89
+	Hs
		1116304 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		PAP1L_HUMAN (421-559): 9.16e-15: 79.2: 13.67
+	Hs
		474021 PAB4L_HUMAN (69-333): 1.17e-44: 160: 15.30		PABP4_HUMAN (457-550): 1.89e-10: 65.7: 10.64
+	Hs
		1116542 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		PABP3_HUMAN (479-559): 6.17e-13: 73.4: 19.75
+	Mm
		665745 TIA1_MOUSE (106-327): 7.74e-43: 156: 14.16		PABP1_MOUSE (457-550): 4.08e-10: 64.5: 10.64
+	Hs
		1031352 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		PABP4_HUMAN (457-550): 1.89e-10: 65.7: 10.64
+	Hs
		516541 LARP7_HUMAN (7-177): 1.36e-38: 148: 29.48		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64
+	Sc
		376709 LHP1_YEAST (8-207): 1.39e-36: 136: 21.76		PABP_YEAST (465-553): 7.06e-12: 69.9: 16.85
+	Sc
		376562 PABP_YEAST (101-315): 1.22e-30: 125: 15.53		PABP_YEAST (465-553): 7.06e-12: 69.9: 16.85
+	Hs
		516689 PABP3_HUMAN (102-408): 3.51e-32: 130: 14.02		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64