Protein: M3K1
Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1) (EC 2.3.2.27)

Gene: M3K1, MAP3K1
Organism: Homo sapiens
Interactions: 239
UniProt ID: Q13233

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004709 - MAP kinase kinase kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

853887

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

11

20

Small-scale

0.981

High

853673

MK08
Mitogen-activated protein kinase 8

5

20

Small-scale

0.928

High

177858

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

5

20

Small-scale

0.922

High

181101

AXIN1
Axin-1

5

8

Small-scale

0.902

High

703571

MK01
Mitogen-activated protein kinase 1

4

20

Small-scale

0.893

High

962010

RHOA
Transforming protein RhoA

4

19

Small-scale

0.891

High

167884

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

3

20

Small-scale

0.888

High

1038287

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

4

19

Small-scale

0.875

High

1098779

M3K1
Mitogen-activated protein kinase kinase kinase 1

3

14

Small-scale

0.861

High

161983

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

3

20

Small-scale

0.834

High

400764

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

9

Small-scale

0.819

High

1087650

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

2

19

Small-scale

0.789

High

853787

MK09
Mitogen-activated protein kinase 9

2

20

Small-scale

0.767

High

1098788

STK38
Serine/threonine-protein kinase 38

2

19

Small-scale

0.754

High

1098791

DDB1
DNA damage-binding protein 1

2

5

Small-scale

0.754

High

578474

BRAF
Serine/threonine-protein kinase B-raf

2

12

Small-scale

0.737

High

891510

GSK3B
Glycogen synthase kinase-3 beta

1

17

Small-scale

0.724

High

1096421

PAK1
Serine/threonine-protein kinase PAK 1

1

17

Small-scale

0.710

High

1098785

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

19

Small-scale

0.691

High

1098844

HIPK2
Homeodomain-interacting protein kinase 2

1

20

Small-scale

0.691

High

1098870

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

19

Small-scale

0.691

High

1090620

TRAF2
TNF receptor-associated factor 2

4

20

Small-scale

0.689

High

857440

NOTC1
Neurogenic locus notch homolog protein 1

1

0

Small-scale

0.687

High

964602

DCAF7
DDB1- and CUL4-associated factor 7

3

3

Small-scale

0.674

High

971475

1433E
14-3-3 protein epsilon

3

20

Small-scale

0.674

High

1098781

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

9

High-throughput

0.665

High

1098792

CDC37
Hsp90 co-chaperone Cdc37

1

8

High-throughput

0.665

High

274560

DNJB6
DnaJ homolog subfamily B member 6

1

7

Small-scale

0.647

High

276683

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

1

9

Small-scale

0.647

High

640160

EPHA1
Ephrin type-A receptor 1

1

1

Small-scale

0.647

High

679335

DNJB2
DnaJ homolog subfamily B member 2

1

3

Small-scale

0.647

High

683449

IKBA
NF-kappa-B inhibitor alpha

1

6

Small-scale

0.647

High

691729

MK03
Mitogen-activated protein kinase 3

1

20

Small-scale

0.647

High

931509

RD23A
UV excision repair protein RAD23 homolog A

1

14

Small-scale

0.647

High

957598

UBE2K
Ubiquitin-conjugating enzyme E2 K

1

13

Small-scale

0.647

High

1098789

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

20

Small-scale

0.647

High

1098803

NEK10
Serine/threonine-protein kinase Nek10

1

16

Small-scale

0.647

High

1098859

DP13A
DCC-interacting protein 13-alpha

1

4

Small-scale

0.647

High

1098864

UBQL1
Ubiquilin-1

1

9

Small-scale

0.647

High

477163

ACM5
Muscarinic acetylcholine receptor M5

1

4

High-throughput

0.625

High

413755

P53
Cellular tumor antigen p53

2

2

Small-scale

0.624

High

987607

GRB2
Growth factor receptor-bound protein 2

2

7

Small-scale

0.624

High

555673

ACTN1
Alpha-actinin-1

1

7

Small-scale

0.621

High

256466

TOM1
Target of Myb1 membrane trafficking protein

2

6

Small-scale

0.619

High

2077

A0A0B4J269
Melanocyte-stimulating hormone receptor

1

18

High-throughput

0.618

High

348119

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

20

Small-scale

0.618

High

411858

NTRK1
High affinity nerve growth factor receptor

1

15

High-throughput

0.618

High

461432

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

468328

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

507183

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

17

High-throughput

0.618

High

507914

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

17

Small-scale

0.618

High

727784

DNJA1
DnaJ homolog subfamily A member 1

1

9

High-throughput

0.618

High

993157

ACTG
Actin, cytoplasmic 2

1

12

High-throughput

0.618

High

1022577

PKD1
Polycystin-1

1

2

Small-scale

0.618

High

1098801

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.618

High

1098830

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

8

High-throughput

0.618

High

1098843

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

19

High-throughput

0.618

High

1098860

VAV3
Guanine nucleotide exchange factor VAV3

1

7

High-throughput

0.618

High

1098863

ALK
ALK tyrosine kinase receptor

1

14

Small-scale

0.618

High

993542

UBC9
SUMO-conjugating enzyme UBC9

2

14

Small-scale

0.606

High

1098821

FRAT1
Proto-oncogene FRAT1

1

0

Small-scale

0.586

High

1098823

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

17

Small-scale

0.575

High

1098800

CRTC1
CREB-regulated transcription coactivator 1

1

1

Small-scale

0.561

High

1098806

CSN6
COP9 signalosome complex subunit 6

1

4

Small-scale

0.561

High

620339

NUCL
Nucleolin

1

2

High-throughput

0.553

High

910487

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

3

High-throughput

0.553

High

1098786

RCN2
Reticulocalbin-2

1

8

High-throughput

0.553

High

1098862

HECD1
E3 ubiquitin-protein ligase HECTD1

1

14

High-throughput

0.553

High

1098816

BAALC
Brain and acute leukemia cytoplasmic protein

1

0

Small-scale

0.549

High

429821

JUN
Transcription factor Jun

2

5

Small-scale

0.543

High

1098829

PKHB2
Pleckstrin homology domain-containing family B member 2

1

0

Small-scale

0.541

High

168529

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

13

High-throughput

0.541

High

906655

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

12

High-throughput

0.541

High

909313

UB2E1
Ubiquitin-conjugating enzyme E2 E1

1

12

High-throughput

0.541

High

957070

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

12

High-throughput

0.541

High

982178

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

12

High-throughput

0.541

High

1098827

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

14

High-throughput

0.541

High

1098868

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

12

High-throughput

0.541

High

1098807

DTX1
E3 ubiquitin-protein ligase DTX1

1

0

Small-scale

0.537

High

140900

NOP56
Nucleolar protein 56

1

1

High-throughput

0.536

High

278070

FLNB
Filamin-B

1

15

Small-scale

0.536

High

732565

ARRB2
Beta-arrestin-2

1

5

High-throughput

0.536

High

882471

ARRB1
Beta-arrestin-1

1

5

High-throughput

0.536

High

990178

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.536

High

1098797

L2GL2
LLGL scribble cell polarity complex component 2

1

2

High-throughput

0.536

High

965653

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

7

High-throughput

0.515

High

973157

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.515

High

984394

RL30
Large ribosomal subunit protein eL30

1

1

High-throughput

0.515

High

65974

CCD69
Coiled-coil domain-containing protein 69

1

1

Small-scale

0.501

High

130949

HIP1
Huntingtin-interacting protein 1

1

15

Small-scale

0.501

High

169538

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

9

Small-scale

0.501

High

296493

STAM2
Signal transducing adapter molecule 2

1

11

Small-scale

0.501

High

300569

KRT36
Keratin, type I cuticular Ha6

1

8

Small-scale

0.501

High

303083

ZFAN5
AN1-type zinc finger protein 5

1

1

Small-scale

0.501

High

320670

UBXN7
UBX domain-containing protein 7

1

3

Small-scale

0.501

High

388066

MBP
Myelin basic protein

1

5

Small-scale

0.501

High

407082

HG2A
HLA class II histocompatibility antigen gamma chain

1

1

Small-scale

0.501

High

652506

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

7

Small-scale

0.501

High

933630

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

1

Small-scale

0.501

High

970215

UB2G1
Ubiquitin-conjugating enzyme E2 G1

1

7

Small-scale

0.501

High

1098780

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

13

Small-scale

0.501

High

1098787

TNIP1
TNFAIP3-interacting protein 1

1

18

Small-scale

0.501

High

1098795

GRAP1
GRIP1-associated protein 1

1

17

Small-scale

0.501

High

1098796

ODFP2
Outer dense fiber protein 2

1

16

Small-scale

0.501

High

1098798

CEP85
Centrosomal protein of 85 kDa

1

20

Small-scale

0.501

High

1098799

DCNL2
DCN1-like protein 2

1

1

Small-scale

0.501

High

1098802

TM1L2
TOM1-like protein 2

1

6

Small-scale

0.501

High

1098808

SPART
Spartin

1

7

Small-scale

0.501

High

1098809

F184A
Protein FAM184A

1

18

Small-scale

0.501

High

1098813

R3GEF
Guanine nucleotide exchange factor for Rab-3A

1

3

Small-scale

0.501

High

1098814

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

5

Small-scale

0.501

High

1098815

RN141
RING finger protein 141

1

1

Small-scale

0.501

High

1098818

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

Small-scale

0.501

High

1098820

STAM1
Signal transducing adapter molecule 1

1

9

Small-scale

0.501

High

1098831

DCNL1
DCN1-like protein 1

1

1

Small-scale

0.501

High

1098833

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

7

Small-scale

0.501

High

1098835

UBAC1
Ubiquitin-associated domain-containing protein 1

1

1

Small-scale

0.501

High

1098837

RN126
E3 ubiquitin-protein ligase RNF126

1

2

Small-scale

0.501

High

1098839

CAR14
Caspase recruitment domain-containing protein 14

1

7

Small-scale

0.501

High

1098840

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

4

Small-scale

0.501

High

1098845

RABE2
Rab GTPase-binding effector protein 2

1

18

Small-scale

0.501

High

1098846

ILRUN
Protein ILRUN

1

1

Small-scale

0.501

High

1098848

ZFAN3
AN1-type zinc finger protein 3

1

1

Small-scale

0.501

High

1098869

HBS1L
HBS1-like protein

1

7

Small-scale

0.501

High

1098871

RN114
E3 ubiquitin-protein ligase RNF114

1

18

Small-scale

0.501

High

1098872

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

3

Small-scale

0.501

High

785135

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.493

High

191629

MAGB2
Melanoma-associated antigen B2

1

1

High-throughput

0.489

High

1098857

PURG
Purine-rich element-binding protein gamma

1

1

High-throughput

0.489

High

799063

BRCA1
Breast cancer type 1 susceptibility protein

1

10

High-throughput

0.481

High

1022823

RHG04
Rho GTPase-activating protein 4

1

2

Small-scale

0.481

High

926972

ATX3
Ataxin-3

1

0

Small-scale

0.480

High

1098810

DEN6B
Protein DENND6B

1

0

Small-scale

0.480

High

1098812

NPL4
Nuclear protein localization protein 4 homolog

1

0

Small-scale

0.480

High

1098822

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

Small-scale

0.480

High

1098849

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

Small-scale

0.480

High

1098851

UBAP1
Ubiquitin-associated protein 1

1

0

Small-scale

0.480

High

1098854

IMPCT
Protein IMPACT

1

0

Small-scale

0.480

High

1098855

APEX2
DNA-(apurinic or apyrimidinic site) endonuclease 2

1

0

Small-scale

0.480

High

1098873

EPN1
Epsin-1

1

0

Small-scale

0.480

High

159635

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

12

Small-scale

0.479

High

172768

XPO1
Exportin-1

1

8

High-throughput

0.479

High

318314

MYO1D
Unconventional myosin-Id

1

20

High-throughput

0.479

High

346998

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.479

High

348488

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

4

High-throughput

0.479

High

408045

TBB4A
Tubulin beta-4A chain

1

15

High-throughput

0.479

High

428380

RLA2
Large ribosomal subunit protein P2

1

2

High-throughput

0.479

High

457409

TBB5
Tubulin beta chain

1

16

High-throughput

0.479

High

474648

VIME
Vimentin

1

8

High-throughput

0.479

High

479810

GSTP1
Glutathione S-transferase P

1

5

Small-scale

0.479

High

535010

BIP
Endoplasmic reticulum chaperone BiP

1

15

High-throughput

0.479

High

537093

HSP7C
Heat shock cognate 71 kDa protein

1

11

High-throughput

0.479

High

600803

HSP76
Heat shock 70 kDa protein 6

1

12

High-throughput

0.479

High

610642

TCPA
T-complex protein 1 subunit alpha

1

14

High-throughput

0.479

High

611850

RL35A
Large ribosomal subunit protein eL33

1

2

High-throughput

0.479

High

612626

RL7
Large ribosomal subunit protein uL30

1

1

High-throughput

0.479

High

637492

FLNA
Filamin-A

1

15

High-throughput

0.479

High

683236

TNR5
Tumor necrosis factor receptor superfamily member 5

1

4

Small-scale

0.479

High

686130

RL13
Large ribosomal subunit protein eL13

1

1

High-throughput

0.479

High

690968

1433T
14-3-3 protein theta

1

20

Small-scale

0.479

High

693719

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

697515

PYR1
Multifunctional protein CAD

1

4

High-throughput

0.479

High

761383

HS71L
Heat shock 70 kDa protein 1-like

1

11

High-throughput

0.479

High

773174

MYH10
Myosin-10

1

13

High-throughput

0.479

High

801298

HSPA9
Stress-70 protein, mitochondrial

1

20

High-throughput

0.479

High

810072

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

821331

TCPZ
T-complex protein 1 subunit zeta

1

14

High-throughput

0.479

High

840697

RS27
Small ribosomal subunit protein eS27

1

5

High-throughput

0.479

High

842355

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.479

High

860182

RS9
Small ribosomal subunit protein uS4

1

2

High-throughput

0.479

High

875940

TCPE
T-complex protein 1 subunit epsilon

1

17

High-throughput

0.479

High

881168

FAS
Fatty acid synthase

1

4

High-throughput

0.479

High

881902

TCPG
T-complex protein 1 subunit gamma

1

14

High-throughput

0.479

High

888025

MCM2
DNA replication licensing factor MCM2

1

8

High-throughput

0.479

High

898632

RL14
Large ribosomal subunit protein eL14

1

1

High-throughput

0.479

High

899020

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.479

High

899370

TCPD
T-complex protein 1 subunit delta

1

14

High-throughput

0.479

High

940233

SYMC
Methionine--tRNA ligase, cytoplasmic

1

9

High-throughput

0.479

High

945785

EPIPL
Epiplakin

1

9

High-throughput

0.479

High

961713

RL37A
Large ribosomal subunit protein eL43

1

1

High-throughput

0.479

High

966269

1433G
14-3-3 protein gamma

1

20

Small-scale

0.479

High

969202

RS8
Small ribosomal subunit protein eS8

1

1

High-throughput

0.479

High

969832

RS16
Small ribosomal subunit protein uS9

1

3

High-throughput

0.479

High

972384

RS14
Small ribosomal subunit protein uS11

1

1

High-throughput

0.479

High

972682

RS23
Small ribosomal subunit protein uS12

1

1

High-throughput

0.479

High

973419

RS11
Small ribosomal subunit protein uS17

1

1

High-throughput

0.479

High

973900

RUXF
Small nuclear ribonucleoprotein F

1

3

High-throughput

0.479

High

977227

RS4X
Small ribosomal subunit protein eS4, X isoform

1

1

High-throughput

0.479

High

978908

RS6
Small ribosomal subunit protein eS6

1

1

High-throughput

0.479

High

985151

RL10A
Large ribosomal subunit protein uL1

1

3

High-throughput

0.479

High

1051743

EF1A2
Elongation factor 1-alpha 2

1

7

High-throughput

0.479

High

1057727

RL18
Large ribosomal subunit protein eL18

1

1

High-throughput

0.479

High

1062437

DHX9
ATP-dependent RNA helicase A

1

3

High-throughput

0.479

High

1098782

CUL3
Cullin-3

1

8

High-throughput

0.479

High

1098783

CUL4A
Cullin-4A

1

8

Small-scale

0.479

High

1098784

CUL4B
Cullin-4B

1

8

Small-scale

0.479

High

1098793

TBB8
Tubulin beta-8 chain

1

16

High-throughput

0.479

High

1098804

TBA1A
Tubulin alpha-1A chain

1

8

High-throughput

0.479

High

1098805

RS27L
Ribosomal protein eS27-like

1

5

High-throughput

0.479

High

1098819

HS105
Heat shock protein 105 kDa

1

18

High-throughput

0.479

High

1098825

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

5

High-throughput

0.479

High

1098836

TBB6
Tubulin beta-6 chain

1

16

High-throughput

0.479

High

1098838

TBB2B
Tubulin beta-2B chain

1

16

High-throughput

0.479

High

1098841

TRIM5
Tripartite motif-containing protein 5

1

8

Small-scale

0.479

High

1098856

ZRAN1
Ubiquitin thioesterase ZRANB1

1

7

High-throughput

0.479

High

1098861

BAG5
BAG family molecular chaperone regulator 5

1

3

High-throughput

0.479

High

1098865

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

1

20

Small-scale

0.479

High

1098866

Q9UQC1
Heat shock protein 72

1

18

High-throughput

0.479

High

1098867

RUVB2
RuvB-like 2

1

2

High-throughput

0.479

High

160490

IRS4
Insulin receptor substrate 4

1

0

High-throughput

0.458

High

359646

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.458

High

944461

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.458

High

1013753

RL24
Large ribosomal subunit protein eL24

1

0

High-throughput

0.458

High

1098824

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.458

High

1098828

FAF2
FAS-associated factor 2

1

3

Small-scale

0.457

High

1098832

CREL1
Protein disulfide isomerase CRELD1

1

3

Small-scale

0.457

High

1098858

GGA2
ADP-ribosylation factor-binding protein GGA2

1

5

Small-scale

0.457

High

396034

ESR1
Estrogen receptor

1

7

Small-scale

0.445

High

424881

ADT2
ADP/ATP translocase 2

1

4

High-throughput

0.437

High

552220

ADT3
ADP/ATP translocase 3

1

4

High-throughput

0.437

High

829373

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

1

High-throughput

0.437

High

855065

NOP2
28S rRNA

1

3

High-throughput

0.437

High

903684

SSRD
Translocon-associated protein subunit delta

1

1

High-throughput

0.437

High

935855

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

1

High-throughput

0.437

High

979595

H4
Histone H4

1

5

High-throughput

0.437

High

1063754

LG3BP
Galectin-3-binding protein

1

2

High-throughput

0.437

High

1098790

AAAT
Neutral amino acid transporter B(0)

1

1

High-throughput

0.437

High

1098794

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

3

High-throughput

0.437

High

1098811

RLA0L
Putative ribosomal protein uL10-like

1

2

High-throughput

0.437

High

1098817

DDB2
DNA damage-binding protein 2

1

8

Small-scale

0.437

High

1098834

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.437

High

1098852

HPBP1
Hsp70-binding protein 1

1

1

High-throughput

0.437

High

1098853

MYOF
Myoferlin

1

5

High-throughput

0.437

High

371929

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.407

High

1098826

R51A1
RAD51-associated protein 1

1

0

Small-scale

0.261

Low

1098842

ASCC2
Activating signal cointegrator 1 complex subunit 2

1

0

Small-scale

0.261

Low

1098847

MINY3
Ubiquitin carboxyl-terminal hydrolase MINDY-3

1

0

Small-scale

0.261

Low

1098850

CUED1
CUE domain-containing protein 1

1

0

Small-scale

0.261

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025