HitPredict

Interactor 1: KPCB (P05771)
Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)
Gene: PRKCB

Interactor 2: RIPK4 (P57078)
Receptor-interacting serine/threonine-protein kinase 4 (EC 2.7.11.1) (Ankyrin repeat domain-containing protein 3) (PKC-delta-interacting protein kinase)
Gene: RIPK4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	23371553
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1_1~Pkinase, Ank_2~Pkinase, Ank_4~Pkinase, Pkinase~Pkinase, Pkinase~Pkinase_C
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0106310 - protein serine kinase activity
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 671 Hs			1 832
+	Hs
		408681 KPCB_HUMAN (1-671): 0: 774: 100.00		Q9H4D1_HUMAN (1-832): 0: 697: 90.75
+	Hs
		883492 KPCD_HUMAN (6-167): 1.49e-54: 199: 40.83		RIPK4_HUMAN (1-832): 0: 726: 100.00
+	Hs
		623870 KPCL_HUMAN (31-192): 2.81e-45: 173: 40.35		RIPK4_HUMAN (1-832): 0: 726: 100.00
+	Hs
		984533 KPCD_HUMAN (6-167): 1.49e-54: 199: 40.83		Q9H4D1_HUMAN (1-832): 0: 697: 90.75
+	Hs
		623883 KPCL_HUMAN (31-192): 2.81e-45: 173: 40.35		Q9H4D1_HUMAN (1-832): 0: 697: 90.75
+	Hs
		783961 KPCI_HUMAN (10-86): 4.39e-13: 74.3: 40.26		RIPK4_HUMAN (1-832): 0: 726: 100.00
+	Hs
		784088 KPCI_HUMAN (10-86): 4.39e-13: 74.3: 40.26		Q9H4D1_HUMAN (1-832): 0: 697: 90.75
+	Hs
		784002 KPCI_HUMAN (10-86): 4.39e-13: 74.3: 40.26		RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31
+	Hs
		983830 KPCZ_HUMAN (10-86): 4.47e-12: 71.2: 36.36		RIPK1_HUMAN (19-278): 1.18e-32: 137: 34.31