HitPredict

Interactor 1: KPCB (P05771)
Protein kinase C beta type (PKC-B) (PKC-beta) (EC 2.7.11.13)
Gene: PRKCB

Interactor 2: TIAM1 (Q13009)
Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)
Gene: TIAM1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	10212259
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~PH, C1_1~RBD, C1_1~RhoGEF, PH~Pkinase
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 671 Hs			1 1591
+	Hs
		566377 KPCA_HUMAN (1-668): 0: 742: 78.89		TIAM1_HUMAN (1-1591): 0: 1876: 100.00
+	Hs
		397159 KPCG_HUMAN (1-668): 0: 678: 66.96		TIAM1_HUMAN (1-1591): 0: 1876: 100.00
+	Hs
		969077 KPCE_HUMAN (5-662): 0: 624: 44.73		TIAM1_HUMAN (1-1591): 0: 1876: 100.00
+	Hs
		984488 KPCD_HUMAN (6-167): 1.49e-54: 199: 40.83		TIAM1_HUMAN (1-1591): 0: 1876: 100.00
+	Hs
		983819 KPCZ_HUMAN (10-86): 4.47e-12: 71.2: 36.36		TIAM1_HUMAN (1-1591): 0: 1876: 100.00
+	Hs
		566376 KPCA_HUMAN (1-668): 0: 742: 78.89		AKP13_HUMAN (646-1590): 1.94e-104: 373: 13.83
+	Rn
		94300 KPCA_RAT (1-668): 0: 741: 78.89		TRIO_RAT (700-1587): 3.63e-86: 315: 15.77
+	Hs
		397161 KPCG_HUMAN (1-668): 0: 678: 66.96		ARHG7_HUMAN (818-1568): 7.77e-97: 333: 14.38
+	Hs
		397170 KPCG_HUMAN (1-668): 0: 678: 66.96		ARHGP_HUMAN (967-1498): 1.79e-80: 279: 17.24
+	Dm
		54650 APKC_DROME (4-86): 7.85e-14: 76.6: 39.76		SIF2_DROME (385-1572): 0: 858: 34.28
+	Hs
		681936 AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33		ARG28_HUMAN (647-1544): 9.69e-115: 402: 13.10
+	Hs
		548689 KPCT_HUMAN (12-665): 2.77e-180: 531: 36.53		VAV_HUMAN (954-1525): 4.75e-87: 306: 15.72
+	Mm
		654978 KPCT_MOUSE (12-665): 0: 533: 36.68		VAV_MOUSE (954-1500): 7.02e-79: 282: 16.21
+	Hs
		681944 AKT1_HUMAN (239-665): 2.36e-159: 469: 37.33		PREX1_HUMAN (991-1488): 1.48e-91: 331: 21.02
+	Hs
		50631 AKT3_HUMAN (284-665): 4.8e-158: 465: 41.48		PKHG3_HUMAN (984-1587): 7.98e-80: 291: 17.03
+	Rn
		223052 AKT3_RAT (284-665): 5.29e-156: 460: 41.48		ARHG7_RAT (991-1446): 1.04e-61: 226: 18.30
+	Hs
		623874 KPCL_HUMAN (31-192): 2.81e-45: 173: 40.35		AKP13_HUMAN (646-1590): 1.94e-104: 373: 13.83
+	Dm
		54659 APKC_DROME (4-86): 7.85e-14: 76.6: 39.76		Q9U7D8_DROME (894-1484): 7.66e-78: 279: 15.91
+	Hs
		983935 KPCZ_HUMAN (10-86): 4.47e-12: 71.2: 36.36		ITSN2_HUMAN (1015-1233): 2.9e-13: 77.4: 30.05