HitPredict

Interactor 1: K1C18 (P05783)
Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)
Gene: KRT18

Interactor 2: CBL (P22681)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene) (Proto-oncogene c-Cbl) (RING finger protein 55) (RING-type E3 ubiquitin transferase CBL) (Signal transduction protein CBL)
Gene: CBL

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.43	0.60	0.508

Property	Details
Experiments	9367879
Identification Methods	two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 430 Hs			1 906
+	Hs
		610513 KRT84_HUMAN (42-391): 2.06e-98: 308: 28.00		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		359303 K1C14_HUMAN (77-428): 5.85e-89: 279: 49.58		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		445005 K1C16_HUMAN (77-404): 2.34e-87: 275: 49.85		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		610361 K1C17_HUMAN (58-420): 5.11e-86: 270: 48.08		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		610433 K2C79_HUMAN (3-408): 2.79e-83: 267: 22.20		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		531534 K2C5_HUMAN (45-400): 2.97e-73: 242: 25.70		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		380445 K2C6B_HUMAN (45-406): 4.05e-73: 241: 23.90		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		610295 K2C6C_HUMAN (45-406): 3.96e-73: 241: 24.18		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		359466 K2C6A_HUMAN (45-406): 1.72e-71: 236: 23.90		CBL_HUMAN (1-906): 0: 917: 100.00
+	Hs
		444454 K1C19_HUMAN (79-389): 5.66e-89: 277: 50.64		ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25
+	Hs
		408896 K1C18_HUMAN (1-430): 1.32e-72: 236: 100.00		ASPP1_HUMAN (445-844): 1.47e-10: 67.3: 10.25