HitPredict

Interactor 1: K2C8 (P05787)
Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8)
Gene: KRT8

Interactor 2: DESP (P15924)
Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)
Gene: DSP

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.576

Property	Details
Experiments	34079125, 9261168
Identification Methods	proximity labelling technology, two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005882 - intermediate filament GO:0045109 - intermediate filament organization GO:0070062 - extracellular exosome and 1 others more... GO:0097110 - scaffold protein binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 483 Hs			1 2871
+	Hs
		531529 K2C5_HUMAN (56-405): 9.54e-66: 223: 71.02		DESP_HUMAN (1-2871): 0: 818: 100.00
+	Hs
		359462 K2C6A_HUMAN (56-405): 8.09e-65: 220: 70.74		DESP_HUMAN (1-2871): 0: 818: 100.00
+	Hs
		444536 K2C7_HUMAN (1-464): 4.13e-154: 448: 60.34		GOGA4_HUMAN (1137-2522): 1.45e-40: 168: 9.60
+	Hs
		444531 K2C7_HUMAN (1-464): 4.13e-154: 448: 60.34		EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71
+	Hs
		517744 K2C3_HUMAN (63-424): 5.15e-135: 405: 65.95		EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71
+	Hs
		580127 K2C4_HUMAN (55-420): 5.63e-110: 337: 61.96		EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71
+	Hs
		821662 K2C6C_HUMAN (56-405): 2.63e-66: 225: 70.74		PLEC_HUMAN (20-1265): 9.18e-42: 172: 9.33
+	Hs
		409080 K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00		PLEC_HUMAN (20-1265): 9.18e-42: 172: 9.33
+	Hs
		408987 K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00		MYH1_HUMAN (24-969): 1.33e-34: 148: 9.08
+	Hs
		213934 KRT86_HUMAN (12-418): 3.09e-87: 277: 53.32		EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71
+	Hs
		885269 K2C73_HUMAN (1-405): 2.21e-86: 277: 54.82		EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71
+	Hs
		234174 K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00		PEPL_HUMAN (1428-2565): 6.62e-28: 126: 14.08
+	Hs
		409211 K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00		AKAP9_HUMAN (1336-2427): 2.28e-27: 125: 8.91
+	Hs
		318791 K2C75_HUMAN (2-405): 3.9e-79: 258: 64.04		EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71
+	Hs
		885321 KRT82_HUMAN (20-440): 2.98e-78: 255: 52.26		EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71
+	Hs
		885251 K2C72_HUMAN (10-405): 1.57e-71: 237: 58.33		EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71
+	Hs
		409039 K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00		EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71
+	Hs
		885248 K1H2_HUMAN (88-402): 1.27e-62: 212: 27.22		EPIPL_HUMAN (2574-2832): 1.51e-11: 73.1: 15.71