HitPredict

Interactor 1: K2C8 (P05787)
Keratin, type II cytoskeletal 8 (Cytokeratin-8) (CK-8) (Keratin-8) (K8) (Type-II keratin Kb8)
Gene: KRT8

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	20098747, 21988832
Identification Methods	pull down, affinity chromatography technology, two hybrid, protein array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 483 Hs			1 419
+	Hs
		1184586 Q7L4M3_HUMAN (205-483): 1.6e-154: 442: 100.00		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		531529 K2C5_HUMAN (56-405): 9.54e-66: 223: 71.02		DESP_HUMAN (45-363): 7.32e-21: 97.8: 15.84
+	Hs
		359462 K2C6A_HUMAN (56-405): 8.09e-65: 220: 70.74		DESP_HUMAN (45-363): 7.32e-21: 97.8: 15.84
+	Hs
		408995 K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00		DESP_HUMAN (45-363): 7.32e-21: 97.8: 15.84
+	Hs
		408987 K2C8_HUMAN (1-483): 2.44e-63: 215: 100.00		MYH1_HUMAN (33-391): 2.48e-10: 65: 11.75