HitPredict

Interactor 1: UBC2 (P06104)
Ubiquitin-conjugating enzyme E2 2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme 2) (Radiation sensitivity protein 6) (Ubiquitin carrier protein UBC2) (Ubiquitin-protein ligase UBC2)
Gene: RAD6

Interactor 2: CUL8 (P47050)
Cullin-8 (Cullin-C) (Regulator of Ty1 transposition protein 101)
Gene: RTT101

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	18704118
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006281 - DNA repair GO:0016567 - protein ubiquitination
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 172 Sc			1 842
+	Sc
		549820 UBC4_YEAST (1-149): 1.43e-79: 234: 38.26		CUL8_YEAST (1-842): 0: 1127: 100.00
+	Hs
		895792 UB2D3_HUMAN (4-150): 1.63e-79: 234: 38.10		CUL4B_HUMAN (305-842): 1e-154: 477: 16.70
+	Hs
		828994 UBE2A_HUMAN (1-151): 9.07e-74: 220: 69.54		CUL4B_HUMAN (305-842): 1e-154: 477: 16.70
+	Hs
		849326 UB2D1_HUMAN (4-150): 6.66e-81: 237: 37.42		CUL4A_HUMAN (305-842): 1.6e-142: 441: 14.16
+	Hs
		895791 UB2D3_HUMAN (4-150): 1.63e-79: 234: 38.10		CUL4A_HUMAN (305-842): 1.6e-142: 441: 14.16
+	Hs
		1043149 UB2E3_HUMAN (3-150): 6.01e-74: 222: 33.11		CUL4A_HUMAN (305-842): 1.6e-142: 441: 14.16
+	Hs
		849325 UB2D1_HUMAN (4-150): 6.66e-81: 237: 37.42		CUL3_HUMAN (305-842): 1.76e-133: 417: 14.33
+	Hs
		919724 UB2D2_HUMAN (4-150): 7.04e-81: 237: 38.10		CUL3_HUMAN (305-842): 1.76e-133: 417: 14.33
+	Hs
		1042223 UB2E3_HUMAN (3-150): 6.01e-74: 222: 33.11		CUL3_HUMAN (305-842): 1.76e-133: 417: 14.33
+	Hs
		1042304 UB2E2_HUMAN (3-150): 5.11e-74: 222: 33.11		CUL3_HUMAN (305-842): 1.76e-133: 417: 14.33
+	Hs
		851812 UB2E1_HUMAN (3-150): 4.36e-73: 219: 33.78		CUL3_HUMAN (305-842): 1.76e-133: 417: 14.33
+	Sp
		804458 UBC4_SCHPO (4-149): 3.97e-79: 233: 40.41		CUL3_SCHPO (297-842): 7.7e-127: 401: 14.29
+	Hs
		1041136 UB2E3_HUMAN (3-150): 6.01e-74: 222: 33.11		CUL1_HUMAN (305-842): 2.43e-124: 394: 15.71
+	Dm
		639393 UBCD1_DROME (4-150): 2.89e-80: 236: 38.10		CUL1_DROME (305-842): 2.02e-117: 375: 13.87
+	Hs
		849324 UB2D1_HUMAN (4-150): 6.66e-81: 237: 37.42		CUL2_HUMAN (304-842): 1.13e-110: 357: 13.20
+	Hs
		895790 UB2D3_HUMAN (4-150): 1.63e-79: 234: 38.10		CUL2_HUMAN (304-842): 1.13e-110: 357: 13.20
+	Hs
		891404 UB2G2_HUMAN (1-148): 8.75e-34: 119: 37.65		CUL3_HUMAN (305-842): 1.76e-133: 417: 14.33