HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.990

The method score is based on:

Property Details
Experiments 14722096, 16271887, 11726652, 35384245, 11579209, 12237455, 12612081, 17481567, 17092689, 11163213, 11506178, 16582879, 19029027, 8999839, 17159996, 21806020, 15588987, 12634852, 8702689
Identification Methods affinity chromatography technology, fluorescent resonance energy transfer, x-ray crystallography, proximity labelling technology, anti tag coimmunoprecipitation, peptide array, solid phase assay, bimolecular fluorescence complementation, anti bait coimmunoprecipitation, phosphatase assay and 5 others

more...
Interaction Type physical association, direct interaction, association, dephosphorylation reaction, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms GO:0008286 - insulin receptor signaling pathway
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 1382
Hs

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Last updated: 15 Jul 2024