Protein: NRDC
Nardilysin (EC 3.4.24.61) (N-arginine dibasic convertase) (NRD convertase) (NRD-C) (Nardilysin convertase)

Gene: NRDC
Organism: Homo sapiens
Interactions: 109
UniProt ID: O43847

Gene Ontology (top 5):
GO:0004222 - metalloendopeptidase activity
GO:0005759 - mitochondrial matrix
GO:0005829 - cytosol
GO:0006508 - proteolysis
GO:0009986 - cell surface

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

229555

ERMAP
Erythroid membrane-associated protein

1

0

High-throughput

0.656

High

229585

FBW1B
F-box/WD repeat-containing protein 11

3

2

High-throughput

0.650

High

229489

NRDC
Nardilysin

1

9

Small-scale

0.647

High

229579

AKIP
Small ribosomal subunit protein mS38

3

0

High-throughput

0.638

High

229575

BATF3
Basic leucine zipper transcriptional factor ATF-like 3

2

4

High-throughput

0.628

High

229587

FBW1A
F-box/WD repeat-containing protein 1A

2

3

High-throughput

0.621

High

229500

P53
Cellular tumor antigen p53

2

1

Small-scale

0.611

High

229571

MOB1A
MOB kinase activator 1A

2

1

Small-scale

0.584

High

229584

ZRAN1
Ubiquitin thioesterase ZRANB1

2

5

High-throughput

0.584

High

229537

DEFI8
Differentially expressed in FDCP 8 homolog

2

1

High-throughput

0.574

High

229559

CDRTF
CMT1A duplicated region transcript 15 protein

2

2

High-throughput

0.574

High

229561

HBEGF
Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor

1

0

Small-scale

0.537

High

229508

RBTN1
Rhombotin-1

1

1

High-throughput

0.536

High

229546

LPIN2
Phosphatidate phosphatase LPIN2

1

1

High-throughput

0.536

High

229564

ERP44
Endoplasmic reticulum resident protein 44

1

1

High-throughput

0.536

High

229506

PGFRA
Platelet-derived growth factor receptor alpha

1

0

High-throughput

0.513

High

229509

NKG2D
NKG2-D type II integral membrane protein

1

0

High-throughput

0.513

High

229526

ATM
Serine-protein kinase ATM

1

0

High-throughput

0.513

High

229530

KIF7
Kinesin-like protein KIF7

1

0

High-throughput

0.513

High

229540

H32
Histone H3.2

1

1

Small-scale

0.512

High

229582

NLGN3
Neuroligin-3

1

1

Small-scale

0.508

High

229586

BAIP2
BAR/IMD domain-containing adapter protein 2

1

0

High-throughput

0.493

High

229502

H2AB1
Histone H2A-Bbd type 1

1

1

High-throughput

0.489

High

229522

LG3BP
Galectin-3-binding protein

1

3

High-throughput

0.489

High

229576

ANKE1
Ankyrin repeat and EF-hand domain-containing protein 1

1

1

High-throughput

0.489

High

143771

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

3

High-throughput

0.479

High

229490

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

1

Small-scale

0.479

High

229491

NCOR1
Nuclear receptor corepressor 1

1

3

Small-scale

0.479

High

229492

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

229495

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

229496

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

4

High-throughput

0.479

High

229499

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

229503

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

4

High-throughput

0.479

High

229505

CH60
60 kDa heat shock protein, mitochondrial

1

7

High-throughput

0.479

High

229507

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

11

High-throughput

0.479

High

229513

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

229517

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

229520

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

229523

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

229524

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

3

High-throughput

0.479

High

229527

PDK1
[Pyruvate dehydrogenase

1

5

High-throughput

0.479

High

229531

BOLA3
BolA-like protein 3

1

3

High-throughput

0.479

High

229539

MOB2
MOB kinase activator 2

1

1

Small-scale

0.479

High

229548

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

229550

CHCH1
Small ribosomal subunit protein mS37

1

2

High-throughput

0.479

High

229552

RCC1L
RCC1-like G exchanging factor-like protein

1

3

High-throughput

0.479

High

229557

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

229562

PMYT1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase

1

2

High-throughput

0.479

High

229563

COQ7
NADPH-dependent 3-demethoxyubiquinone 3-hydroxylase, mitochondrial

1

5

High-throughput

0.479

High

229565

DHRS4
Dehydrogenase/reductase SDR family member 4

1

4

High-throughput

0.479

High

229566

TR61B
tRNA

1

2

High-throughput

0.479

High

229570

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

229572

LYRM4
LYR motif-containing protein 4

1

4

High-throughput

0.479

High

229573

PPA6
Lysophosphatidic acid phosphatase type 6

1

2

High-throughput

0.479

High

229581

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

229583

MRES1
Mitochondrial transcription rescue factor 1

1

1

High-throughput

0.479

High

229592

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

1

2

Small-scale

0.479

High

188116

HDAC3
Histone deacetylase 3

1

0

Small-scale

0.458

High

229510

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.458

High

229516

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

Small-scale

0.458

High

229525

STK3
Serine/threonine-protein kinase 3

1

0

Small-scale

0.458

High

229549

RL36L
Ribosomal protein eL42-like

1

0

High-throughput

0.458

High

229568

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

0

Small-scale

0.458

High

229521

SRPK2
SRSF protein kinase 2

1

4

High-throughput

0.445

High

229528

NF2L2
Nuclear factor erythroid 2-related factor 2

1

4

High-throughput

0.445

High

229533

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

229534

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.445

High

229493

RHBT1
Rho-related BTB domain-containing protein 1

1

3

High-throughput

0.437

High

229511

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

229512

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

229529

DUS5
Dual specificity protein phosphatase 5

1

3

High-throughput

0.437

High

229532

COBL1
Cordon-bleu protein-like 1

1

1

Small-scale

0.437

High

229535

MIC27
MICOS complex subunit MIC27

1

1

High-throughput

0.437

High

229538

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

229541

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

9

High-throughput

0.437

High

229547

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.437

High

229558

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.437

High

229567

YTHD1
YTH domain-containing family protein 1

1

2

High-throughput

0.437

High

229569

OPA3
Optic atrophy 3 protein

1

1

High-throughput

0.437

High

229580

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.437

High

229588

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

1

2

High-throughput

0.437

High

229591

NCOR2
Nuclear receptor corepressor 2

1

3

Small-scale

0.437

High

229593

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

5

High-throughput

0.437

High

229514

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.426

High

229515

RL28
Large ribosomal subunit protein eL28

1

0

High-throughput

0.426

High

229577

ASF1B
Histone chaperone ASF1B

1

0

High-throughput

0.426

High

229494

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.407

High

229497

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.407

High

229501

JUN
Transcription factor Jun

1

5

High-throughput

0.407

High

229542

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.407

High

229553

MF14A
Hippocampus abundant transcript 1 protein

1

2

High-throughput

0.407

High

229543

FMR1N
FMR1 neighbor protein

3

0

High-throughput

0.347

High

229545

SEPT1
Septin-1

3

0

High-throughput

0.347

High

229551

ZN707
Zinc finger protein 707

3

0

High-throughput

0.347

High

229574

LUC7L
Putative RNA-binding protein Luc7-like 1

3

0

High-throughput

0.347

High

229536

T184A
Transmembrane protein 184A

2

0

High-throughput

0.328

High

229544

MET25
Probable methyltransferase-like protein 25

2

0

High-throughput

0.324

High

229498

PRM2
Protamine-2

1

0

High-throughput

0.279

Low

229518

CLK3
Dual specificity protein kinase CLK3

1

0

High-throughput

0.279

Low

229554

CC140
Coiled-coil domain-containing protein 140

1

0

High-throughput

0.279

Low

229556

UIMC1
BRCA1-A complex subunit RAP80

1

0

High-throughput

0.279

Low

229590

PCDBF
Protocadherin beta-15

1

0

High-throughput

0.279

Low

219398

TNF12
Tumor necrosis factor ligand superfamily member 12

1

0

High-throughput

0.249

Low

229560

PNKP
Bifunctional polynucleotide phosphatase/kinase

1

0

Small-scale

0.249

Low

229578

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

229589

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

229504

CT456
Cancer/testis antigen family 45 member A6

1

0

High-throughput

0.232

Low

229519

RAB15
Ras-related protein Rab-15

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025