HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: CALX (P27824)
Calnexin (IP90) (Major histocompatibility complex class I antigen-binding protein p88) (p90)
Gene: CANX

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 592
+	Hs
		160999 INSR_HUMAN (1-1382): 0: 1530: 100.00		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		435545 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		161003 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Rn
		544766 INSR_RAT (1-1382): 0: 1527: 94.44		CALR_RAT (67-470): 7.8e-147: 431: 37.35
+	Hs
		654090 EPHA3_HUMAN (570-1319): 7.94e-174: 545: 20.56		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		654091 EPHA8_HUMAN (644-1322): 3.66e-168: 531: 20.68		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		445825 ROS1_HUMAN (511-1377): 3.38e-158: 530: 22.63		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		383628 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		654899 ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		654092 LTK_HUMAN (1013-1291): 2e-71: 259: 44.52		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		384315 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		654370 NTRK3_HUMAN (996-1290): 1.93e-64: 238: 39.43		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		654101 UFO_HUMAN (789-1294): 1.77e-61: 229: 31.09		CALX_HUMAN (1-592): 0: 786: 100.00
+	Hs
		160994 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		160995 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		161071 NTRK3_HUMAN (996-1290): 1.93e-64: 238: 39.43		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		161016 ERBB3_HUMAN (33-369): 1.76e-27: 123: 20.11		CLGN_HUMAN (11-546): 0: 652: 59.85
+	Hs
		384313 NTRK1_HUMAN (996-1286): 9.16e-68: 247: 42.62		CALR_HUMAN (67-470): 1.19e-141: 418: 38.33
+	Hs
		653574 MERTK_HUMAN (835-1301): 1.61e-62: 234: 32.36		CALR_HUMAN (67-470): 1.19e-141: 418: 38.33
+	Hs
		653493 UFO_HUMAN (789-1294): 1.77e-61: 229: 31.09		CALR_HUMAN (67-470): 1.19e-141: 418: 38.33