Protein: EPHA3
Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)

Gene: EPHA3
Organism: Homo sapiens
Interactions: 102
UniProt ID: P29320

Gene Ontology (top 5):
GO:0005003 - ephrin receptor activity
GO:0005004 - GPI-linked ephrin receptor activity
GO:0005005 - transmembrane-ephrin receptor activity
GO:0005524 - ATP binding
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

710611

EFNA5
Ephrin-A5

6

20

Small-scale

0.944

High

710630

EPHA7
Ephrin type-A receptor 7

4

19

Small-scale

0.899

High

710074

EPHA2
Ephrin type-A receptor 2

2

19

High-throughput

0.802

High

380263

DRA
HLA class II histocompatibility antigen, DR alpha chain

2

13

High-throughput

0.789

High

710610

EFNB2
Ephrin-B2

2

20

Small-scale

0.778

High

710650

LRIQ1
Leucine-rich repeat- and IQ domain-containing protein 1

2

20

High-throughput

0.726

High

710603

EPHB2
Ephrin type-B receptor 2

1

17

Small-scale

0.724

High

710652

SRPK1
SRSF protein kinase 1

1

11

High-throughput

0.710

High

710633

CEA21
Cell adhesion molecule CEACAM21

2

8

High-throughput

0.705

High

710641

DUS18
Dual specificity protein phosphatase 18

1

20

High-throughput

0.698

High

710646

STYX
Serine/threonine/tyrosine-interacting protein

1

20

High-throughput

0.698

High

177803

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

14

High-throughput

0.691

High

710612

EPHA5
Ephrin type-A receptor 5

1

19

High-throughput

0.691

High

710614

EPHA4
Ephrin type-A receptor 4

1

18

High-throughput

0.691

High

710632

CDC37
Hsp90 co-chaperone Cdc37

1

19

High-throughput

0.691

High

362173

ABL1
Tyrosine-protein kinase ABL1

1

20

Small-scale

0.647

High

440391

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.647

High

557120

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

Small-scale

0.647

High

635237

EFNA1
Ephrin-A1

1

20

Small-scale

0.647

High

710608

EFNA3
Ephrin-A3

1

20

Small-scale

0.647

High

710609

EFNA4
Ephrin-A4

1

20

Small-scale

0.647

High

710619

EFNB1
Ephrin-B1

1

20

Small-scale

0.647

High

710613

EPHB4
Ephrin type-B receptor 4

1

17

High-throughput

0.646

High

710661

DUS21
Dual specificity protein phosphatase 21

1

20

High-throughput

0.625

High

410644

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.621

High

136300

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.618

High

296445

STAM2
Signal transducing adapter molecule 2

1

20

High-throughput

0.618

High

373790

RASN
GTPase NRas

1

20

High-throughput

0.618

High

375209

RASK
GTPase KRas

1

20

High-throughput

0.618

High

461178

HS90A
Heat shock protein HSP 90-alpha

1

20

Small-scale

0.618

High

463359

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

564802

NCAM1
Neural cell adhesion molecule 1

1

7

Small-scale

0.618

High

699596

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

High-throughput

0.618

High

710606

MUC18
Cell surface glycoprotein MUC18

1

15

High-throughput

0.618

High

710607

CRK
Adapter molecule crk

1

20

Small-scale

0.618

High

710616

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

710618

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.618

High

710621

DYST
Dystonin

1

12

High-throughput

0.618

High

710622

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

20

High-throughput

0.618

High

710627

SRC8
Src substrate cortactin

1

20

Small-scale

0.618

High

710629

RAB35
Ras-related protein Rab-35

1

10

High-throughput

0.618

High

710634

PDZ11
PDZ domain-containing protein 11

1

20

High-throughput

0.618

High

710637

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.618

High

710645

PARD3
Partitioning defective 3 homolog

1

20

High-throughput

0.618

High

710651

ERBIN
Erbin

1

18

High-throughput

0.618

High

710663

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

15

High-throughput

0.618

High

710664

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.618

High

710666

WDR6
tRNA

1

13

High-throughput

0.618

High

710670

KDIS
Kinase D-interacting substrate of 220 kDa

1

10

High-throughput

0.618

High

710655

RNF5
E3 ubiquitin-protein ligase RNF5

1

6

Small-scale

0.561

High

710662

TM231
Transmembrane protein 231

2

1

High-throughput

0.558

High

158553

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

1

7

High-throughput

0.541

High

710615

TPTE
Putative tyrosine-protein phosphatase TPTE

1

10

High-throughput

0.541

High

710649

RBM18
Probable RNA-binding protein 18

1

5

High-throughput

0.541

High

321965

NFAT5
Nuclear factor of activated T-cells 5

1

4

High-throughput

0.536

High

710623

SLAF1
Signaling lymphocytic activation molecule

1

20

High-throughput

0.536

High

710644

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

3

High-throughput

0.536

High

710605

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

20

Small-scale

0.516

High

710647

H2B1H
Histone H2B type 1-H

1

1

High-throughput

0.515

High

710624

SMAD4
Mothers against decapentaplegic homolog 4

1

4

High-throughput

0.506

High

413253

P53
Cellular tumor antigen p53

1

3

Small-scale

0.501

High

710672

FBX7
F-box only protein 7

1

3

High-throughput

0.501

High

457950

TRY1
Serine protease 1

1

11

High-throughput

0.500

High

698405

CALX
Calnexin

1

12

High-throughput

0.500

High

62288

MTMRB
Myotubularin-related protein 11

1

3

High-throughput

0.494

High

710658

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

8

High-throughput

0.494

High

710656

F118B
Protein FAM118B

1

1

High-throughput

0.489

High

161003

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

17

Small-scale

0.479

High

169448

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

20

High-throughput

0.479

High

332878

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

11

High-throughput

0.479

High

603849

CXA1
Gap junction alpha-1 protein

1

13

High-throughput

0.479

High

642644

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

5

High-throughput

0.479

High

710604

MYH9
Myosin-9

1

5

Small-scale

0.479

High

710617

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

6

High-throughput

0.479

High

710620

CLH1
Clathrin heavy chain 1

1

2

Small-scale

0.479

High

710626

DSG2
Desmoglein-2

1

20

High-throughput

0.479

High

710628

FLOT2
Flotillin-2

1

12

High-throughput

0.479

High

710631

AAAT
Neutral amino acid transporter B(0)

1

14

High-throughput

0.479

High

710636

F1711
Protein FAM171A1

1

12

High-throughput

0.479

High

710639

AHNK2
Protein AHNAK2

1

4

High-throughput

0.479

High

710643

VANG1
Vang-like protein 1

1

4

High-throughput

0.479

High

710654

CDCA3
Cell division cycle-associated protein 3

1

8

High-throughput

0.479

High

710657

RHG39
Rho GTPase-activating protein 39

1

10

High-throughput

0.479

High

710659

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

6

High-throughput

0.479

High

710665

JPH1
Junctophilin-1

1

8

High-throughput

0.479

High

710668

VAPA
Vesicle-associated membrane protein-associated protein A

1

11

High-throughput

0.479

High

710669

TRM7
tRNA

1

7

High-throughput

0.479

High

710671

NISCH
Nischarin

1

20

High-throughput

0.479

High

595956

H12
Histone H1.2

1

2

High-throughput

0.470

High

72915

FHAD1
Forkhead-associated domain-containing protein 1

1

6

High-throughput

0.457

High

554780

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

1

High-throughput

0.457

High

254825

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

11

High-throughput

0.445

High

710625

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

10

High-throughput

0.445

High

710653

RUFY1
RUN and FYVE domain-containing protein 1

1

18

Small-scale

0.445

High

71294

F1712
Protein FAM171A2

1

12

High-throughput

0.437

High

710638

LRC49
Leucine-rich repeat-containing protein 49

1

20

High-throughput

0.437

High

710648

CK052
Uncharacterized protein C11orf52

1

5

High-throughput

0.437

High

710660

GCP60
Golgi resident protein GCP60

1

9

High-throughput

0.437

High

710667

GGA3
ADP-ribosylation factor-binding protein GGA3

1

20

High-throughput

0.437

High

710635

MDH1B
Putative malate dehydrogenase 1B

1

0

High-throughput

0.261

Low

710640

CC116
Coiled-coil domain-containing protein 116

1

0

High-throughput

0.249

Low

710642

TET5D
Terminal nucleotidyltransferase 5D

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025