HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	15522217
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005159 - insulin-like growth factor receptor binding GO:0005886 - plasma membrane GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 304
+	Hs
		411332 INSR_HUMAN (1-1382): 0: 1530: 100.00		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		411288 INSR_HUMAN (1-1382): 0: 1530: 100.00		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Hs
		411523 INSR_HUMAN (1-1382): 0: 1530: 100.00		VAV3_HUMAN (11-189): 1.56e-33: 131: 26.15
+	Hs
		411292 INSR_HUMAN (1-1382): 0: 1530: 100.00		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Rn
		499158 INSR_RAT (1-1382): 0: 1527: 94.44		PLCG1_RAT (8-302): 1.46e-26: 111: 15.72
+	Hs
		411352 INSR_HUMAN (1-1382): 0: 1530: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Rn
		88904 INSR_RAT (1-1382): 0: 1527: 94.44		D4A3M8_RAT (59-195): 2.79e-11: 65.3: 20.55
+	Hs
		435576 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		CRK_HUMAN (1-304): 7.82e-68: 215: 100.00
+	Hs
		435801 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		VAV3_HUMAN (11-189): 1.56e-33: 131: 26.15
+	Hs
		435602 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		435526 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		537729 INSRR_HUMAN (13-1341): 0: 1293: 51.12		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		802810 EPHA4_HUMAN (562-1354): 0: 565: 20.36		CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07
+	Hs
		855777 EPHA4_HUMAN (562-1354): 0: 565: 20.36		VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74
+	Hs
		580965 EPHA4_HUMAN (562-1354): 0: 565: 20.36		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		562635 EPHA4_HUMAN (562-1354): 0: 565: 20.36		PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89
+	Hs
		872610 EPHB1_HUMAN (571-1318): 0: 569: 21.86		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		872630 EPHA4_HUMAN (562-1354): 0: 565: 20.36		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		557644 EPHB1_HUMAN (571-1318): 0: 569: 21.86		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		209018 EPHA4_HUMAN (562-1354): 0: 565: 20.36		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00