Protein: HXK2
Hexokinase-2 (EC 2.7.1.1) (Hexokinase type II) (HK II) (Hexokinase-B) (Muscle form hexokinase)

Gene: HXK2, HK2
Organism: Homo sapiens
Interactions: 108
UniProt ID: P52789

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0001678 - intracellular glucose homeostasis
GO:0002931 - response to ischemia
GO:0004340 - glucokinase activity
GO:0004396 - hexokinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

621455

HXK1
Hexokinase-1

3

14

High-throughput

0.855

High

914070

HXK3
Hexokinase-3

2

14

High-throughput

0.811

High

914136

UBQL1
Ubiquilin-1

2

4

High-throughput

0.646

High

241165

PRKN
E3 ubiquitin-protein ligase parkin

3

5

Small-scale

0.640

High

640820

VDAC1
Non-selective voltage-gated ion channel VDAC1

2

7

Small-scale

0.611

High

914135

FBX2
F-box only protein 2

2

1

High-throughput

0.601

High

914079

CUL3
Cullin-3

2

4

High-throughput

0.571

High

914082

TOM20
Mitochondrial import receptor subunit TOM20 homolog

2

1

High-throughput

0.571

High

914143

MTCH2
Mitochondrial carrier homolog 2

2

4

High-throughput

0.571

High

445793

ENOA
Alpha-enolase

1

5

High-throughput

0.541

High

914125

UBQL4
Ubiquilin-4

1

4

High-throughput

0.541

High

461298

HS90A
Heat shock protein HSP 90-alpha

1

7

High-throughput

0.536

High

914080

IRF3
Interferon regulatory factor 3

1

3

High-throughput

0.536

High

914098

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

914107

IRF7
Interferon regulatory factor 7

1

3

High-throughput

0.536

High

914114

FOXB1
Forkhead box protein B1

1

6

High-throughput

0.536

High

914138

VDAC3
Non-selective voltage-gated ion channel VDAC3

1

7

High-throughput

0.536

High

914122

TIGAR
Fructose-2,6-bisphosphatase TIGAR

1

4

Small-scale

0.534

High

848956

MAGAC
Melanoma-associated antigen 12

1

3

High-throughput

0.523

High

848008

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

0

High-throughput

0.513

High

914127

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.513

High

914129

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

0

High-throughput

0.513

High

288075

FOXH1
Forkhead box protein H1

1

5

High-throughput

0.489

High

318126

IPO13
Importin-13

1

1

High-throughput

0.489

High

886254

ARL4D
ADP-ribosylation factor-like protein 4D

1

4

High-throughput

0.489

High

914072

FOXL2
Forkhead box protein L2

1

6

High-throughput

0.489

High

914076

FOXL1
Forkhead box protein L1

1

6

High-throughput

0.489

High

914092

LYPD4
Ly6/PLAUR domain-containing protein 4

1

1

High-throughput

0.489

High

914095

FOXI2
Forkhead box protein I2

1

6

High-throughput

0.489

High

914137

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

1

High-throughput

0.489

High

166889

MGST3
Glutathione S-transferase 3, mitochondrial

1

1

High-throughput

0.479

High

293409

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

345554

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

363014

EGFR
Epidermal growth factor receptor

1

2

High-throughput

0.479

High

411630

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

487119

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

574083

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

2

High-throughput

0.479

High

660003

COF1
Cofilin-1

1

2

High-throughput

0.479

High

798884

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

830394

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

914075

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

914086

MIDN
Midnolin

1

1

High-throughput

0.479

High

914091

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

914099

MIRO2
Mitochondrial Rho GTPase 2

1

8

High-throughput

0.479

High

914100

S15A3
Solute carrier family 15 member 3

1

3

High-throughput

0.479

High

914106

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

914112

COX14
Cytochrome c oxidase assembly protein COX14

1

1

High-throughput

0.479

High

914113

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

914121

TRI36
E3 ubiquitin-protein ligase TRIM36

1

4

Small-scale

0.479

High

914123

PXMP2
Peroxisomal membrane protein 2

1

1

High-throughput

0.479

High

914124

FBX6
F-box only protein 6

1

1

High-throughput

0.479

High

914126

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

1

High-throughput

0.479

High

914128

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

5

High-throughput

0.479

High

914130

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.479

High

914131

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

914132

MTCH1
Mitochondrial carrier homolog 1

1

4

High-throughput

0.479

High

914133

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

914134

TES
Testin

1

1

High-throughput

0.479

High

914141

FIS1
Mitochondrial fission 1 protein

1

1

High-throughput

0.479

High

914142

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

137682

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

274995

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

565247

ITA4
Integrin alpha-4

1

0

High-throughput

0.458

High

634372

LMNB1
Lamin-B1

1

0

High-throughput

0.458

High

914074

KPCE
Protein kinase C epsilon type

1

0

Small-scale

0.458

High

914078

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

914081

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

914083

TWST1
Twist-related protein 1

1

0

Small-scale

0.458

High

914085

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

914087

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.458

High

914105

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

914108

OTUL
Ubiquitin thioesterase otulin

1

0

Small-scale

0.458

High

914109

OPTN
Optineurin

1

0

High-throughput

0.458

High

914115

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

914116

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.458

High

914120

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

914073

SUMO2
Small ubiquitin-related modifier 2

1

2

High-throughput

0.457

High

104126

F5H1C8
Solute carrier family 15 member 3

1

3

High-throughput

0.445

High

619631

VCAM1
Vascular cell adhesion protein 1

1

1

High-throughput

0.445

High

914088

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

914090

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.445

High

914097

SPNS2
Sphingosine-1-phosphate transporter SPNS2

1

1

High-throughput

0.445

High

914117

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

914139

ITM2B
Integral membrane protein 2B

1

2

High-throughput

0.445

High

371535

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.437

High

588270

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

694996

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

767762

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

848229

MAGA3
Melanoma-associated antigen 3

1

3

Small-scale

0.437

High

914077

RFA4
Replication protein A 30 kDa subunit

1

2

High-throughput

0.437

High

914089

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

1

Small-scale

0.437

High

914096

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

914119

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

653208

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

844914

EAA2
Excitatory amino acid transporter 2

1

0

High-throughput

0.426

High

914101

S39AB
Zinc transporter ZIP11

1

0

High-throughput

0.426

High

914094

CLC4G
C-type lectin domain family 4 member G

1

1

Small-scale

0.407

High

217315

PROM1
Prominin-1

1

0

Small-scale

0.292

High

914084

INF2
Inverted formin-2

1

0

High-throughput

0.279

Low

914110

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

914111

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.279

Low

914118

SEM4C
Semaphorin-4C

1

0

High-throughput

0.279

Low

914071

CTBP2
C-terminal-binding protein 2

1

0

High-throughput

0.249

Low

914093

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

914140

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

914102

SPX3
Sugar phosphate exchanger 3

1

0

High-throughput

0.232

Low

914103

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low

914104

S38A5
Sodium-coupled neutral amino acid transporter 5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025