HitPredict

Interactor 1: INSR (P06213)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: HYOU1 (Q9Y4L1)
Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4)
Gene: HYOU1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	33961781, 35384245
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0016020 - membrane GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1382 Hs			1 999
+	Hs
		411458 INSR_HUMAN (1-1382): 0: 1530: 100.00		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		320795 INSR_HUMAN (1-1382): 0: 1530: 100.00		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		435811 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		320797 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Rn
		544811 INSR_RAT (1-1382): 0: 1527: 94.44		HSP7C_RAT (682-815): 1.96e-30: 130: 16.42
+	Hs
		435511 IGF1R_HUMAN (31-1380): 0: 1353: 56.11		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		665690 EPHB2_HUMAN (521-1316): 3.12e-175: 551: 20.21		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		665546 EPHA8_HUMAN (644-1322): 3.66e-168: 531: 20.68		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		445887 ROS1_HUMAN (511-1377): 3.38e-158: 530: 22.63		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		1072565 EPHA7_HUMAN (562-1356): 4.76e-172: 541: 19.48		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		665505 EPHA8_HUMAN (644-1322): 3.66e-168: 531: 20.68		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		320817 EPHA8_HUMAN (644-1322): 3.66e-168: 531: 20.68		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		320798 ROS1_HUMAN (511-1377): 3.38e-158: 530: 22.63		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		384047 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		320789 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		383646 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		HSP74_HUMAN (33-964): 0: 785: 25.64
+	Hs
		1267783 ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		320928 ALK_HUMAN (982-1339): 1.96e-70: 263: 40.53		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		503499 EPHB2_HUMAN (521-1316): 3.12e-175: 551: 20.21		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		383840 ERBB2_HUMAN (978-1381): 5.36e-93: 330: 25.67		Q53FC7_HUMAN (682-813): 3.1e-27: 120: 20.46