HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: CD2 (P06729)
T-cell surface antigen CD2 (Erythrocyte receptor) (LFA-2) (LFA-3 receptor) (Rosette receptor) (T-cell surface antigen T11/Leu-5) (CD antigen CD2)
Gene: CD2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.613

Property	Details
Experiments	8551220, 9677430
Identification Methods	affinity chromatography technology, pull down, experimental interaction detection
Interaction Type	physical association, direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005102 - signaling receptor binding GO:0005886 - plasma membrane
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 351
+	Hs
		411939 FYN_HUMAN (30-507): 0: 586: 59.01		CD2_HUMAN (1-351): 4.65e-87: 267: 100.00
+	Hs
		416917 ITK_HUMAN (7-500): 1.08e-177: 515: 33.33		CD2_HUMAN (1-351): 4.65e-87: 267: 100.00
+	Hs
		433691 LYN_HUMAN (1-509): 0: 582: 62.72		CXAR_HUMAN (7-331): 1.53e-55: 187: 14.57
+	Hs
		433317 YES_HUMAN (26-507): 0: 581: 58.06		CXAR_HUMAN (7-331): 1.53e-55: 187: 14.57
+	Hs
		411818 LCK_HUMAN (1-509): 0: 661: 100.00		SLAF6_HUMAN (7-231): 9.14e-24: 101: 17.43
+	Hs
		412176 FYN_HUMAN (30-507): 0: 586: 59.01		SLAF1_HUMAN (1-294): 1.15e-44: 158: 15.64
+	Hs
		412347 FYN_HUMAN (30-507): 0: 586: 59.01		CD244_HUMAN (18-309): 1.39e-44: 158: 15.34
+	Hs
		523136 SRC_HUMAN (20-507): 0: 586: 55.00		CD244_HUMAN (18-309): 1.39e-44: 158: 15.34
+	Hs
		523015 SRC_HUMAN (20-507): 0: 586: 55.00		CEA21_HUMAN (1-277): 4.92e-43: 152: 14.67
+	Hs
		454828 FGR_HUMAN (1-507): 0: 579: 52.76		SLAF1_HUMAN (1-294): 1.15e-44: 158: 15.64
+	Hs
		789096 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		SLAF5_HUMAN (11-317): 1.52e-49: 171: 17.35
+	Mm
		639452 LYN_MOUSE (1-509): 0: 585: 62.33		FCRL5_MOUSE (65-281): 1.64e-14: 76.5: 16.95
+	Hs
		434111 LYN_HUMAN (1-509): 0: 582: 62.72		ROBO1_HUMAN (17-134): 3.31e-15: 79.1: 13.22
+	Hs
		433569 LYN_HUMAN (1-509): 0: 582: 62.72		CD22_HUMAN (11-345): 1.55e-14: 76.8: 7.25
+	Mm
		763408 FYN_MOUSE (30-507): 0: 586: 58.80		SLAF1_MOUSE (37-291): 8.38e-13: 70.3: 19.11
+	Dm
		53796 ABL_DROME (43-502): 3.42e-171: 525: 42.34		A1Z921_DROME (9-337): 6.7e-13: 71.8: 9.73