HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	9763511, 21269457
Identification Methods	pull down, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006919 - activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0019901 - protein kinase binding GO:0045121 - membrane raft
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 758
+	Hs
		411960 FYN_HUMAN (30-507): 0: 586: 59.01		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496189 SRC_HUMAN (20-507): 0: 586: 55.00		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		337321 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		411582 LCK_HUMAN (1-509): 0: 661: 100.00		MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84
+	Hs
		203198 LCK_HUMAN (1-509): 0: 661: 100.00		SYNJ1_HUMAN (7-411): 1.53e-09: 63.9: 9.76
+	Hs
		411964 FYN_HUMAN (30-507): 0: 586: 59.01		MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55
+	Hs
		503258 SRC_HUMAN (20-507): 0: 586: 55.00		MTAP2_HUMAN (16-758): 2.28e-30: 131: 23.55
+	Hs
		522749 SRC_HUMAN (20-507): 0: 586: 55.00		MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84
+	Hs
		433560 LYN_HUMAN (1-509): 0: 582: 62.72		MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84
+	Hs
		297808 LYN_HUMAN (1-509): 0: 582: 62.72		K0754_HUMAN (5-450): 2.95e-22: 105: 11.86
+	Hs
		412362 FYN_HUMAN (30-507): 0: 586: 59.01		MAGE1_HUMAN (222-587): 4.83e-09: 61.9: 16.22
+	Hs
		152571 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		KMT2D_HUMAN (226-636): 8.62e-26: 116: 19.55
+	Hs
		337335 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		MUC1_HUMAN (242-751): 2.66e-25: 114: 10.84