HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: CD44 (P16070)
CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
Gene: CD44

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	8576267, 9573028
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0034116 - positive regulation of heterotypic cell-cell adhesion GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 742
+	Mm
		411914 LCK_MOUSE (1-509): 0: 657: 96.86		CD44_MOUSE (1-742): 0: 540: 65.90
+	Hs
		411984 FYN_HUMAN (30-507): 0: 586: 59.01		CD44_HUMAN (1-742): 0: 610: 100.00
+	Hs
		522750 SRC_HUMAN (20-507): 0: 586: 55.00		CD44_HUMAN (1-742): 0: 610: 100.00
+	Hs
		433944 LYN_HUMAN (1-509): 0: 582: 62.72		PGCB_HUMAN (13-491): 2.84e-100: 331: 15.24
+	Hs
		297808 LYN_HUMAN (1-509): 0: 582: 62.72		K0754_HUMAN (216-656): 5.15e-32: 136: 10.08
+	Hs
		412362 FYN_HUMAN (30-507): 0: 586: 59.01		MAGE1_HUMAN (218-648): 7.05e-13: 74.3: 14.16
+	Hs
		64077 SRC_HUMAN (20-507): 0: 586: 55.00		L37A2_HUMAN (217-652): 3.4e-11: 69.3: 10.13