Protein: SI1L2
Signal-induced proliferation-associated 1-like protein 2 (SIPA1-like protein 2)

Gene: SI1L2, SIPA1L2
Organism: Homo sapiens
Interactions: 128
UniProt ID: Q9P2F8

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0051056 - regulation of small GTPase mediated signal transduction
GO:0098928 - presynaptic signal transduction
GO:0098978 - glutamatergic synapse

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

730314

1433B
14-3-3 protein beta/alpha

5

20

High-throughput

0.722

High

684420

DDX6
Probable ATP-dependent RNA helicase DDX6

5

3

High-throughput

0.720

High

966971

1433G
14-3-3 protein gamma

4

20

High-throughput

0.699

High

990820

1433Z
14-3-3 protein zeta/delta

4

20

High-throughput

0.699

High

1049863

1433F
14-3-3 protein eta

4

20

High-throughput

0.699

High

208746

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

9

High-throughput

0.691

High

244612

SI1L3
Signal-induced proliferation-associated 1-like protein 3

1

10

High-throughput

0.691

High

1390855

SIPA1
Signal-induced proliferation-associated protein 1

1

8

High-throughput

0.691

High

1454570

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

2

High-throughput

0.691

High

691503

1433T
14-3-3 protein theta

3

20

High-throughput

0.667

High

972088

1433E
14-3-3 protein epsilon

2

10

High-throughput

0.635

High

1411354

LZTS2
Leucine zipper putative tumor suppressor 2

4

20

High-throughput

0.633

High

1447724

PDLI7
PDZ and LIM domain protein 7

1

7

High-throughput

0.618

High

376047

RASK
GTPase KRas

1

16

High-throughput

0.618

High

1255901

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.618

High

1454572

AP3M1
AP-3 complex subunit mu-1

3

1

High-throughput

0.616

High

1429105

NXF2
Nuclear RNA export factor 2

2

0

High-throughput

0.602

High

349274

LATS1
Serine/threonine-protein kinase LATS1

2

6

High-throughput

0.584

High

653741

PROZ
Vitamin K-dependent protein Z

2

1

High-throughput

0.574

High

1430549

TSYL1
Testis-specific Y-encoded-like protein 1

2

1

High-throughput

0.574

High

1454573

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

2

11

High-throughput

0.574

High

710537

EPHA2
Ephrin type-A receptor 2

1

5

High-throughput

0.553

High

936471

AFAD
Afadin

1

17

High-throughput

0.553

High

978371

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.553

High

1208595

SMAG2
Protein Smaug homolog 2

1

1

High-throughput

0.553

High

1353295

PARD3
Partitioning defective 3 homolog

1

15

High-throughput

0.553

High

244902

LZTS3
Leucine zipper putative tumor suppressor 3

1

17

High-throughput

0.536

High

570998

MIF
Macrophage migration inhibitory factor

1

1

High-throughput

0.536

High

777576

K22E
Keratin, type II cytoskeletal 2 epidermal

1

3

High-throughput

0.536

High

860038

RL28
Large ribosomal subunit protein eL28

1

1

High-throughput

0.536

High

1382546

TRI52
E3 ubiquitin-protein ligase TRIM52

1

2

High-throughput

0.536

High

1417893

DUS16
Dual specificity protein phosphatase 16

1

1

High-throughput

0.536

High

1430084

RGAP1
Rac GTPase-activating protein 1

1

2

High-throughput

0.536

High

1435395

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.536

High

1454568

LZTS1
Leucine zipper putative tumor suppressor 1

1

20

High-throughput

0.536

High

1226303

CP135
Centrosomal protein of 135 kDa

2

4

High-throughput

0.533

High

1233962

Q6ICH2
single-stranded DNA cytosine deaminase

2

2

High-throughput

0.533

High

1203277

ODFP2
Outer dense fiber protein 2

2

5

High-throughput

0.521

High

1367473

ESR2
Estrogen receptor beta

2

15

High-throughput

0.521

High

1311118

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.513

High

1454575

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

66023

U119B
Protein unc-119 homolog B

1

1

High-throughput

0.489

High

175999

N4BP3
NEDD4-binding protein 3

1

13

High-throughput

0.489

High

1105182

U119A
Protein unc-119 homolog A

1

1

High-throughput

0.489

High

1217925

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

5

High-throughput

0.489

High

272519

OBSL1
Obscurin-like protein 1

1

4

High-throughput

0.479

High

299410

FLOT1
Flotillin-1

1

2

High-throughput

0.479

High

414759

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

437025

K1C18
Keratin, type I cytoskeletal 18

1

1

High-throughput

0.479

High

437374

K2C8
Keratin, type II cytoskeletal 8

1

2

High-throughput

0.479

High

440234

LCK
Tyrosine-protein kinase Lck

1

1

High-throughput

0.479

High

459782

PROF1
Profilin-1

1

1

High-throughput

0.479

High

475037

VIME
Vimentin

1

10

High-throughput

0.479

High

570620

GFAP
Glial fibrillary acidic protein

1

10

High-throughput

0.479

High

604253

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

613479

VINC
Vinculin

1

4

High-throughput

0.479

High

730935

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

765078

CTNB1
Catenin beta-1

1

3

High-throughput

0.479

High

831568

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

872831

SOX2
Transcription factor SOX-2

1

6

High-throughput

0.479

High

891342

GSK3A
Glycogen synthase kinase-3 alpha

1

8

High-throughput

0.479

High

891846

GSK3B
Glycogen synthase kinase-3 beta

1

8

High-throughput

0.479

High

896654

VASP
Vasodilator-stimulated phosphoprotein

1

3

High-throughput

0.479

High

953153

ACTB
Actin, cytoplasmic 1

1

3

High-throughput

0.479

High

958212

ARP3
Actin-related protein 3

1

6

High-throughput

0.479

High

1033802

PO5F1
POU domain, class 5, transcription factor 1

1

3

High-throughput

0.479

High

1114517

CUL3
Cullin-3

1

5

High-throughput

0.479

High

1116086

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

11

High-throughput

0.479

High

1149387

STIL
SCL-interrupting locus protein

1

1

High-throughput

0.479

High

1156235

ZYX
Zyxin

1

4

High-throughput

0.479

High

1197113

AMOT
Angiomotin

1

5

High-throughput

0.479

High

1228487

FTM
Protein fantom

1

9

High-throughput

0.479

High

1248209

SAS6
Spindle assembly abnormal protein 6 homolog

1

5

High-throughput

0.479

High

1252271

SYNE3
Nesprin-3

1

6

High-throughput

0.479

High

1325530

FBXW8
F-box/WD repeat-containing protein 8

1

8

High-throughput

0.479

High

1408281

PTN18
Tyrosine-protein phosphatase non-receptor type 18

1

4

High-throughput

0.479

High

1448697

LATS2
Serine/threonine-protein kinase LATS2

1

8

High-throughput

0.479

High

1454563

HOOK1
Protein Hook homolog 1

1

6

High-throughput

0.479

High

1105428

SF3B2
Splicing factor 3B subunit 2

1

1

High-throughput

0.470

High

1310060

DEN6A
Protein DENND6A

1

0

High-throughput

0.458

High

1454569

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.458

High

1382789

FERM2
Fermitin family homolog 2

1

1

High-throughput

0.457

High

1383337

ABC3D
DNA dC->dU-editing enzyme APOBEC-3D

1

2

High-throughput

0.445

High

1402918

CK5P2
CDK5 regulatory subunit-associated protein 2

1

8

High-throughput

0.445

High

174628

TRI66
Tripartite motif-containing protein 66

1

4

High-throughput

0.437

High

189897

STX7
Syntaxin-7

1

1

High-throughput

0.437

High

573706

ENPL
Endoplasmin

1

3

High-throughput

0.437

High

878574

PAXI
Paxillin

1

4

High-throughput

0.437

High

905229

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.437

High

1156609

CCDC6
Coiled-coil domain-containing protein 6

1

8

High-throughput

0.437

High

1159886

OCLN
Occludin

1

4

High-throughput

0.437

High

1178437

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

1229118

RNF43
E3 ubiquitin-protein ligase RNF43

1

1

High-throughput

0.437

High

1256621

CE128
Centrosomal protein of 128 kDa

1

9

High-throughput

0.437

High

1271232

DPPA4
Developmental pluripotency-associated protein 4

1

2

High-throughput

0.437

High

1287141

PATL1
Protein PAT1 homolog 1

1

1

High-throughput

0.437

High

1326369

NIN
Ninein

1

11

High-throughput

0.437

High

1333023

F184A
Protein FAM184A

1

4

High-throughput

0.437

High

1391202

BICD1
Protein bicaudal D homolog 1

1

6

High-throughput

0.437

High

1412830

PCGF1
Polycomb group RING finger protein 1

1

3

High-throughput

0.437

High

1414975

CP250
Centrosome-associated protein CEP250

1

5

High-throughput

0.437

High

1437226

NANOG
Homeobox protein NANOG

1

8

High-throughput

0.437

High

1454562

ANFY1
Rabankyrin-5

1

2

High-throughput

0.437

High

1454564

ANC2
Anaphase-promoting complex subunit 2

1

7

High-throughput

0.437

High

1454565

FBW1B
F-box/WD repeat-containing protein 11

1

6

High-throughput

0.437

High

1454566

ALK
ALK tyrosine kinase receptor

1

3

High-throughput

0.437

High

1454571

NINL
Ninein-like protein

1

12

High-throughput

0.437

High

73467

B2CML4
single-stranded DNA cytosine deaminase

1

2

High-throughput

0.407

High

1310973

ZNT8
Proton-coupled zinc antiporter SLC30A8

1

2

High-throughput

0.407

High

1346813

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

2

High-throughput

0.407

High

568004

PRG2
Bone marrow proteoglycan

3

0

High-throughput

0.347

High

1211461

CF141
Uncharacterized protein C6orf141

2

0

High-throughput

0.328

High

1454567

CELA1
Chymotrypsin-like elastase family member 1

2

0

High-throughput

0.328

High

1331113

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

2

0

High-throughput

0.316

High

1017818

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.279

Low

1178907

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

1316003

NRSN1
Neurensin-1

1

0

High-throughput

0.279

Low

1332773

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

1392419

SYMM
Methionine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

1449120

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.279

Low

1454574

SNX5
Sorting nexin-5

1

0

High-throughput

0.279

Low

230924

ORC5
Origin recognition complex subunit 5

1

0

High-throughput

0.251

Low

642594

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.251

Low

176564

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.249

Low

948176

DJB13
DnaJ homolog subfamily B member 13

1

0

High-throughput

0.249

Low

1289677

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.249

Low

1392358

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.249

Low

1063082

S20A2
Sodium-dependent phosphate transporter 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025