HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: PECA1 (P16284)
Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31)
Gene: PECAM1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	9624175
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0045121 - membrane raft GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 738
+	Hs
		442774 HCK_HUMAN (1-509): 0: 602: 65.04		PECA1_HUMAN (1-738): 1.44e-140: 432: 100.00
+	Hs
		411985 FYN_HUMAN (30-507): 0: 586: 59.01		PECA1_HUMAN (1-738): 1.44e-140: 432: 100.00
+	Hs
		522751 SRC_HUMAN (20-507): 0: 586: 55.00		PECA1_HUMAN (1-738): 1.44e-140: 432: 100.00
+	Hs
		433561 LYN_HUMAN (1-509): 0: 582: 62.72		PECA1_HUMAN (1-738): 1.44e-140: 432: 100.00
+	Hs
		433242 YES_HUMAN (26-507): 0: 581: 58.06		PECA1_HUMAN (1-738): 1.44e-140: 432: 100.00
+	Hs
		557441 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		PECA1_HUMAN (1-738): 1.44e-140: 432: 100.00
+	Hs
		434019 LYN_HUMAN (1-509): 0: 582: 62.72		ROBO2_HUMAN (11-737): 1.39e-82: 288: 12.20
+	Hs
		433804 LYN_HUMAN (1-509): 0: 582: 62.72		SDK2_HUMAN (247-738): 8.87e-51: 194: 12.69
+	Mm
		639452 LYN_MOUSE (1-509): 0: 585: 62.33		FCRL5_MOUSE (230-631): 2.04e-45: 173: 17.99
+	Hs
		433569 LYN_HUMAN (1-509): 0: 582: 62.72		CD22_HUMAN (282-633): 8.62e-41: 162: 15.93
+	Hs
		255429 LCK_HUMAN (1-509): 0: 661: 100.00		OBSL1_HUMAN (72-603): 1.4e-14: 80.3: 15.01
+	Hs
		297881 FYN_HUMAN (30-507): 0: 586: 59.01		NFASC_HUMAN (292-736): 1.17e-37: 153: 12.71
+	Hs
		434111 LYN_HUMAN (1-509): 0: 582: 62.72		ROBO1_HUMAN (405-725): 5.45e-33: 139: 11.87
+	Hs
		433742 LYN_HUMAN (1-509): 0: 582: 62.72		PTK7_HUMAN (8-235): 3.28e-27: 120: 12.45
+	Hs
		433249 YES_HUMAN (26-507): 0: 581: 58.06		VCAM1_HUMAN (28-407): 7.14e-17: 86.9: 19.75
+	Hs
		297880 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		NFASC_HUMAN (292-736): 1.17e-37: 153: 12.71