HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: LCP2 (Q13094)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	21725281, 10556826
Identification Methods	anti tag coimmunoprecipitation, far western blotting
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0035556 - intracellular signal transduction GO:0050852 - T cell receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 533
+	Hs
		442821 HCK_HUMAN (1-509): 0: 602: 65.04		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		412165 FYN_HUMAN (30-507): 0: 586: 59.01		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		522951 SRC_HUMAN (20-507): 0: 586: 55.00		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		433736 LYN_HUMAN (1-509): 0: 582: 62.72		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Mm
		763395 FYN_MOUSE (30-507): 0: 586: 58.80		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		996556 ITK_HUMAN (7-500): 1.08e-177: 515: 33.33		LCP2_HUMAN (1-533): 1.59e-78: 258: 100.00
+	Hs
		203198 LCK_HUMAN (1-509): 0: 661: 100.00		SYNJ1_HUMAN (10-466): 1.18e-22: 104: 11.71
+	Mm
		976831 ITK_MOUSE (6-500): 4.47e-177: 513: 33.53		LCP2_MOUSE (1-531): 8.21e-72: 240: 80.98
+	Hs
		411582 LCK_HUMAN (1-509): 0: 661: 100.00		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Mm
		536209 FGR_MOUSE (1-507): 0: 591: 53.19		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Mm
		763411 FYN_MOUSE (30-507): 0: 586: 58.80		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Mm
		639462 LYN_MOUSE (1-509): 0: 585: 62.33		CLNK_MOUSE (150-528): 6.78e-37: 143: 28.57
+	Hs
		433917 LYN_HUMAN (1-509): 0: 582: 62.72		BLNK_HUMAN (75-520): 4.29e-35: 139: 24.28
+	Hs
		523025 SRC_HUMAN (20-507): 0: 586: 55.00		TENS3_HUMAN (83-512): 1.87e-28: 122: 12.50
+	Hs
		297808 LYN_HUMAN (1-509): 0: 582: 62.72		K0754_HUMAN (18-469): 5.29e-28: 121: 11.97
+	Hs
		522749 SRC_HUMAN (20-507): 0: 586: 55.00		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Hs
		433560 LYN_HUMAN (1-509): 0: 582: 62.72		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92
+	Mm
		976834 ITK_MOUSE (6-500): 4.47e-177: 513: 33.53		BLNK_MOUSE (78-520): 1.72e-37: 145: 23.27
+	Hs
		412433 FYN_HUMAN (30-507): 0: 586: 59.01		MYO16_HUMAN (111-438): 6.65e-11: 67.4: 12.90
+	Hs
		337335 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		MUC1_HUMAN (87-469): 7.93e-15: 79.7: 9.92