HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: ASB9 (Q96DX5)
Ankyrin repeat and SOCS box protein 9 (ASB-9)
Gene: ASB9

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.61	1.00	0.783

Property	Details
Experiments	32296183, unassigned1304
Identification Methods	two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SOCS_box, Ank_2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0035556 - intracellular signal transduction
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 294
+	Hs
		411885 LCK_HUMAN (1-509): 0: 661: 100.00		KDIS_HUMAN (4-178): 2.86e-33: 131: 20.56
+	Hs
		411697 LCK_HUMAN (1-509): 0: 661: 100.00		ANK3_HUMAN (173-291): 4e-31: 124: 13.12
+	Hs
		434071 LYN_HUMAN (1-509): 0: 582: 62.72		KDIS_HUMAN (4-178): 2.86e-33: 131: 20.56
+	Hs
		433730 LYN_HUMAN (1-509): 0: 582: 62.72		ANK3_HUMAN (173-291): 4e-31: 124: 13.12
+	Hs
		433701 LYN_HUMAN (1-509): 0: 582: 62.72		ANK2_HUMAN (162-290): 8.92e-30: 121: 14.39
+	Hs
		434072 LYN_HUMAN (1-509): 0: 582: 62.72		ANR50_HUMAN (213-291): 1.39e-09: 60.9: 10.13
+	Hs
		337406 ABL1_HUMAN (49-502): 8.1e-171: 513: 42.21		DAPK1_HUMAN (4-130): 3.59e-26: 110: 17.97