HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: MED28 (Q9H204)
Mediator of RNA polymerase II transcription subunit 28 (Endothelial-derived protein 1) (Mediator complex subunit 28) (Merlin and Grb2-interacting cytoskeletal protein) (Magicin) (Tumor angiogenesis marker EG-1)
Gene: MED28

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.50	0.581

Property	Details
Experiments	16899217, 10656681
Identification Methods	pull down, two hybrid, anti bait coimmunoprecipitation, protein kinase assay
Interaction Type	physical association, association, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 509 Hs			1 178
+	Hs
		442883 HCK_HUMAN (1-509): 0: 602: 65.04		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00
+	Hs
		412351 FYN_HUMAN (30-507): 0: 586: 59.01		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00
+	Hs
		523146 SRC_HUMAN (20-507): 0: 586: 55.00		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00
+	Hs
		433471 YES_HUMAN (26-507): 0: 581: 58.06		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00
+	Mm
		763402 FYN_MOUSE (30-507): 0: 586: 58.80		MED28_MOUSE (1-178): 8.45e-99: 284: 94.38
+	Hs
		789091 ABL2_HUMAN (57-502): 3.29e-166: 502: 42.95		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00
+	Hs
		789008 TEC_HUMAN (7-503): 2.17e-169: 494: 32.56		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00
+	Hs
		986396 BTK_HUMAN (7-505): 1.49e-167: 490: 33.27		MED28_HUMAN (1-178): 5.44e-109: 310: 100.00