HitPredict

Interactor 1: LCK (P06239)
Tyrosine-protein kinase Lck (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (Protein YT16) (Proto-oncogene Lck) (T cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: SH2B3 (Q9UQQ2)
SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk)
Gene: SH2B3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10799879
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 509 Hs			1 575
+	Hs
		145968 HCK_HUMAN (1-509): 0: 602: 65.04		SH2B2_HUMAN (25-573): 1.06e-116: 361: 31.30
+	Hs
		411580 LCK_HUMAN (1-509): 0: 661: 100.00		VAV_HUMAN (192-573): 3.94e-49: 184: 11.77
+	Mm
		411932 LCK_MOUSE (1-509): 0: 657: 96.86		SOCS6_MOUSE (77-464): 1.03e-51: 187: 16.71
+	Hs
		411573 LCK_HUMAN (1-509): 0: 661: 100.00		SRC_HUMAN (204-539): 3.8e-47: 174: 13.12
+	Hs
		411552 LCK_HUMAN (1-509): 0: 661: 100.00		YES_HUMAN (229-557): 2.62e-45: 169: 13.20
+	Hs
		411626 LCK_HUMAN (1-509): 0: 661: 100.00		CSK_HUMAN (354-444): 2.06e-32: 131: 29.67
+	Hs
		442772 HCK_HUMAN (1-509): 0: 602: 65.04		SRC_HUMAN (204-539): 3.8e-47: 174: 13.12
+	Hs
		411633 LCK_HUMAN (1-509): 0: 661: 100.00		KSYK_HUMAN (363-573): 4.78e-25: 111: 15.57
+	Hs
		442828 HCK_HUMAN (1-509): 0: 602: 65.04		GRB14_HUMAN (196-450): 9.19e-45: 168: 17.94
+	Mm
		536205 FGR_MOUSE (1-507): 0: 591: 53.19		FGR_MOUSE (244-551): 1.24e-45: 170: 13.33
+	Hs
		522734 SRC_HUMAN (20-507): 0: 586: 55.00		SRC_HUMAN (204-539): 3.8e-47: 174: 13.12
+	Gg
		337663 SRC_CHICK (25-507): 0: 589: 56.79		SRC_CHICK (225-539): 1.19e-45: 170: 14.68
+	Rn
		989767 LYN_RAT (1-509): 0: 590: 62.33		SRC_RAT (204-539): 2.39e-45: 169: 13.01
+	Hs
		433231 SRC_HUMAN (20-507): 0: 586: 55.00		YES_HUMAN (229-557): 2.62e-45: 169: 13.20
+	Hs
		129163 LCK_HUMAN (1-509): 0: 661: 100.00		P85B_HUMAN (329-463): 2.73e-18: 90.9: 18.38
+	Hs
		522805 SRC_HUMAN (20-507): 0: 586: 55.00		SHC1_HUMAN (350-453): 1.1e-29: 125: 34.62
+	Mm
		536207 FGR_MOUSE (1-507): 0: 591: 53.19		KSYK_MOUSE (364-573): 8.39e-24: 107: 15.64
+	Hs
		129173 HCK_HUMAN (1-509): 0: 602: 65.04		P85B_HUMAN (329-463): 2.73e-18: 90.9: 18.38
+	Hs
		522758 SRC_HUMAN (20-507): 0: 586: 55.00		PLCG1_HUMAN (348-575): 7.81e-20: 96.2: 14.96
+	Hs
		129185 SRC_HUMAN (20-507): 0: 586: 55.00		P85B_HUMAN (329-463): 2.73e-18: 90.9: 18.38