Protein: DDR2
Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)

Gene: DDR2
Organism: Homo sapiens
Interactions: 129
UniProt ID: Q16832

Gene Ontology (top 5):
GO:0001503 - ossification
GO:0003416 - endochondral bone growth
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0005518 - collagen binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

711364

SHC1
SHC-transforming protein 1

2

20

Small-scale

0.821

High

1062978

DDR1
Epithelial discoidin domain-containing receptor 1

2

20

High-throughput

0.811

High

468429

HS90B
Heat shock protein HSP 90-beta

2

20

High-throughput

0.789

High

461537

HS90A
Heat shock protein HSP 90-alpha

2

20

High-throughput

0.767

High

1158340

CDC37
Hsp90 co-chaperone Cdc37

2

18

High-throughput

0.705

High

909017

NEK4
Serine/threonine-protein kinase Nek4

1

20

High-throughput

0.691

High

1156960

NTRK3
NT-3 growth factor receptor

1

17

High-throughput

0.691

High

557331

SRC
Proto-oncogene tyrosine-protein kinase Src

1

19

Small-scale

0.665

High

187356

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

20

High-throughput

0.646

High

987673

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.646

High

1103756

PLD1
Phospholipase D1

1

3

High-throughput

0.646

High

1125457

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

18

High-throughput

0.646

High

1163977

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

19

High-throughput

0.646

High

1163991

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

20

High-throughput

0.646

High

412011

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

466280

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

611149

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

20

High-throughput

0.618

High

845664

MUC18
Cell surface glycoprotein MUC18

1

20

High-throughput

0.618

High

901838

RAB9A
Ras-related protein Rab-9A

1

20

High-throughput

0.618

High

955936

RAB8A
Ras-related protein Rab-8A

1

16

High-throughput

0.618

High

978040

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

1038632

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

20

High-throughput

0.618

High

1163962

TRI67
Tripartite motif-containing protein 67

1

19

High-throughput

0.618

High

1163970

HAVR1
Hepatitis A virus cellular receptor 1

1

2

Small-scale

0.618

High

1163975

OSBL8
Oxysterol-binding protein-related protein 8

1

15

High-throughput

0.618

High

1163990

RAB21
Ras-related protein Rab-21

1

20

High-throughput

0.618

High

1163992

ALK
ALK tyrosine kinase receptor

1

20

High-throughput

0.618

High

618258

CADH2
Cadherin-2

2

20

Small-scale

0.611

High

1163987

CHRD1
Cysteine and histidine-rich domain-containing protein 1

2

5

High-throughput

0.611

High

1097939

CBLB
E3 ubiquitin-protein ligase CBL-B

2

20

Small-scale

0.601

High

1163955

DDR2
Discoidin domain-containing receptor 2

1

19

Small-scale

0.575

High

1163966

LRC52
Leucine-rich repeat-containing protein 52

1

20

High-throughput

0.575

High

533673

CLUS
Clusterin

2

5

High-throughput

0.558

High

1017429

FOXK1
Forkhead box protein K1

2

6

High-throughput

0.543

High

569041

COBA2

1

7

Small-scale

0.536

High

390593

TFR1
Transferrin receptor protein 1

1

7

High-throughput

0.536

High

1008174

PRKDC
DNA-dependent protein kinase catalytic subunit

1

10

High-throughput

0.536

High

384161

CO1A1
Collagen alpha-1(I) chain

1

7

Small-scale

0.501

High

422204

A4
Amyloid-beta precursor protein

1

16

Small-scale

0.501

High

168857

PLD2
Phospholipase D2

1

3

High-throughput

0.500

High

239840

PCDH7
Protocadherin-7

1

20

High-throughput

0.500

High

299989

CBPD
Carboxypeptidase D

1

7

High-throughput

0.500

High

342895

HERC2
E3 ubiquitin-protein ligase HERC2

1

20

High-throughput

0.500

High

389742

FETUA
Alpha-2-HS-glycoprotein

1

6

High-throughput

0.500

High

409403

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

18

High-throughput

0.500

High

540024

BCR
Breakpoint cluster region protein

1

20

High-throughput

0.500

High

701832

ABCD3
ATP-binding cassette sub-family D member 3

1

10

High-throughput

0.500

High

764352

CTNA1
Catenin alpha-1

1

11

High-throughput

0.500

High

813105

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

6

High-throughput

0.500

High

1063775

LG3BP
Galectin-3-binding protein

1

12

High-throughput

0.500

High

1064433

DSC1
Desmocollin-1

1

20

High-throughput

0.500

High

1098406

DNJC3
DnaJ homolog subfamily C member 3

1

20

High-throughput

0.500

High

1128512

DSC3
Desmocollin-3

1

20

High-throughput

0.500

High

1163961

ATD3B
ATPase family AAA domain-containing protein 3B

1

14

High-throughput

0.500

High

1163963

KTN1
Kinectin

1

10

High-throughput

0.500

High

1163976

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

3

High-throughput

0.500

High

1163978

JPH1
Junctophilin-1

1

8

High-throughput

0.500

High

1163979

WDR6
tRNA

1

20

High-throughput

0.500

High

1163980

ATD3A
ATPase family AAA domain-containing protein 3A

1

18

High-throughput

0.500

High

1163983

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

1

High-throughput

0.500

High

1163984

HACD3
Very-long-chain

1

7

High-throughput

0.500

High

1163989

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

14

High-throughput

0.500

High

418163

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

6

High-throughput

0.489

High

963073

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

7

High-throughput

0.489

High

1163986

DJB11
DnaJ homolog subfamily B member 11

1

20

High-throughput

0.489

High

221588

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

4

High-throughput

0.479

High

333028

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

20

High-throughput

0.479

High

359668

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

6

High-throughput

0.479

High

424918

ADT2
ADP/ATP translocase 2

1

11

High-throughput

0.479

High

538604

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

2

High-throughput

0.479

High

547619

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

3

High-throughput

0.479

High

553201

KCRB
Creatine kinase B-type

1

2

High-throughput

0.479

High

556119

CADH1
Cadherin-1

1

20

Small-scale

0.479

High

566996

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

2

High-throughput

0.479

High

596572

EPCAM
Epithelial cell adhesion molecule

1

3

High-throughput

0.479

High

608885

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

12

High-throughput

0.479

High

764797

CTNB1
Catenin beta-1

1

20

High-throughput

0.479

High

895569

SERPH
Serpin H1

1

12

High-throughput

0.479

High

959177

ABCE1
ATP-binding cassette sub-family E member 1

1

10

High-throughput

0.479

High

1062485

DHX9
ATP-dependent RNA helicase A

1

15

High-throughput

0.479

High

1111552

STIM1
Stromal interaction molecule 1

1

13

High-throughput

0.479

High

1154040

MSMO1
Methylsterol monooxygenase 1

1

1

High-throughput

0.479

High

1163968

DNJC9
DnaJ homolog subfamily C member 9

1

20

High-throughput

0.479

High

1163969

AP2M1
AP-2 complex subunit mu

1

14

High-throughput

0.479

High

1163973

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

2

High-throughput

0.479

High

1163974

RFIP5
Rab11 family-interacting protein 5

1

13

High-throughput

0.479

High

1163985

VAPA
Vesicle-associated membrane protein-associated protein A

1

20

High-throughput

0.479

High

1163988

BAZ1B
Tyrosine-protein kinase BAZ1B

1

12

High-throughput

0.479

High

1163994

HYOU1
Hypoxia up-regulated protein 1

1

20

High-throughput

0.479

High

1163971

VMP1
Vacuole membrane protein 1

1

0

Small-scale

0.458

High

296331

CP7B1
Cytochrome P450 7B1

1

8

High-throughput

0.457

High

337739

SGPL1
Sphingosine-1-phosphate lyase 1

1

7

High-throughput

0.457

High

417462

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

6

High-throughput

0.457

High

635598

FILA
Filaggrin

1

9

High-throughput

0.457

High

829223

RFC3
Replication factor C subunit 3

1

3

High-throughput

0.457

High

829408

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

13

High-throughput

0.457

High

916268

TXTP
Tricarboxylate transport protein, mitochondrial

1

17

High-throughput

0.457

High

935880

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

9

High-throughput

0.457

High

1029688

FOXK2
Forkhead box protein K2

1

6

High-throughput

0.457

High

1141575

OZF
Zinc finger protein OZF

1

7

High-throughput

0.457

High

1163958

MA7D1
MAP7 domain-containing protein 1

1

19

High-throughput

0.457

High

1163959

ZN260
Zinc finger protein 260

1

7

High-throughput

0.457

High

1163965

MACOI
Macoilin

1

8

High-throughput

0.457

High

1163967

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

7

High-throughput

0.457

High

1163982

TECR
Very-long-chain enoyl-CoA reductase

1

6

High-throughput

0.457

High

1113225

CUL3
Cullin-3

1

11

High-throughput

0.445

High

1163957

MICB
MHC class I polypeptide-related sequence B

1

20

High-throughput

0.445

High

137729

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

7

High-throughput

0.437

High

184061

ACOX3
Peroxisomal acyl-coenzyme A oxidase 3

1

5

High-throughput

0.437

High

255642

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

5

High-throughput

0.437

High

277708

H2AY
Core histone macro-H2A.1

1

4

High-throughput

0.437

High

336111

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

20

High-throughput

0.437

High

338337

SC24A
Protein transport protein Sec24A

1

20

High-throughput

0.437

High

338483

SC24B
Protein transport protein Sec24B

1

20

High-throughput

0.437

High

469090

SRPRA
Signal recognition particle receptor subunit alpha

1

11

High-throughput

0.437

High

906062

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

11

High-throughput

0.437

High

912778

AGFG1
Arf-GAP domain and FG repeat-containing protein 1

1

20

High-throughput

0.437

High

1004634

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.437

High

1148892

SC23A
Protein transport protein Sec23A

1

20

High-throughput

0.437

High

1148980

SC23B
Protein transport protein Sec23B

1

20

High-throughput

0.437

High

1163956

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

12

High-throughput

0.437

High

1163964

STX12
Syntaxin-12

1

9

High-throughput

0.437

High

1163981

RBM28
RNA-binding protein 28

1

10

High-throughput

0.437

High

1163993

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.279

Low

649769

SPR2E
Small proline-rich protein 2E

1

0

High-throughput

0.261

Low

1048530

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.261

Low

1163960

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.261

Low

1163972

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.261

Low


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Last updated: 11Aug2025