HitPredict

Interactor 1: LCK (P06240)
Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (p56-LCK)
Gene: LCK

Interactor 2: PK3CG (Q9JHG7)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma) (PtdIns-3-kinase subunit p110-gamma) (p110gamma) (Phosphoinositide-3-kinase catalytic gamma polypeptide) (Serine/threonine protein kinase PIK3CG) (EC 2.7.11.1) (p120-PI3K)
Gene: Pik3cg

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17998387
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~SH2, PI3K_C2~SH2, PI3Ka~SH2
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0016310 - phosphorylation
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 509 Mm			1 1102
+	Hs
		411640 LCK_HUMAN (1-509): 0: 634: 96.86		PK3CG_HUMAN (1-1102): 0: 1330: 94.10
+	Hs
		433644 LYN_HUMAN (1-509): 0: 566: 63.37		PK3CG_HUMAN (1-1102): 0: 1330: 94.10
+	Hs
		411630 LCK_HUMAN (1-509): 0: 634: 96.86		PK3CA_HUMAN (23-1093): 0: 986: 32.50
+	Hs
		522837 SRC_HUMAN (2-507): 0: 576: 54.13		PK3CA_HUMAN (23-1093): 0: 986: 32.50
+	Mm
		403443 SRC_MOUSE (6-507): 0: 574: 54.17		P3C2A_MOUSE (317-1095): 0: 739: 31.77
+	Hs
		411746 LCK_HUMAN (1-509): 0: 634: 96.86		Q4LE69_HUMAN (612-1094): 5.41e-135: 453: 23.33
+	Hs
		433799 LYN_HUMAN (1-509): 0: 566: 63.37		Q4LE69_HUMAN (612-1094): 5.41e-135: 453: 23.33
+	Hs
		337465 ABL1_HUMAN (34-506): 1.69e-167: 505: 40.54		ATR_HUMAN (698-1043): 3.2e-88: 315: 18.33