HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PH~SH3_1
Common GO terms	GO:0005768 - endosome GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0019899 - enzyme binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 537 Hs			1 870
+	Hs
		522862 SRC_HUMAN (1-537): 0: 598: 68.21		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		412411 FYN_HUMAN (1-537): 0: 643: 100.00		DYN3_HUMAN (1-870): 0: 994: 78.41
+	Hs
		411645 LCK_HUMAN (40-535): 0: 551: 57.60		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		442794 HCK_HUMAN (1-535): 0: 548: 56.64		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		522926 SRC_HUMAN (1-537): 0: 598: 68.21		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Hs
		433651 LYN_HUMAN (1-535): 0: 535: 54.48		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		337399 ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		337437 ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Hs
		337597 ABL1_HUMAN (42-537): 7.36e-167: 504: 39.56		DYN3_HUMAN (1-870): 0: 994: 78.41
+	Ce
		220206 SRC2_CAEEL (31-535): 1.43e-178: 514: 51.97		DYN1_CAEEL (3-823): 0: 899: 61.86
+	Ce
		106652 SRC1_CAEEL (1-535): 5.09e-173: 500: 49.63		DYN1_CAEEL (3-823): 0: 899: 61.86