HitPredict

Interactor 1: FYN (P06241)
Tyrosine-protein kinase Fyn (EC 2.7.10.2) (Proto-oncogene Syn) (Proto-oncogene c-Fyn) (Src-like kinase) (SLK) (p59-Fyn)
Gene: FYN

Interactor 2: GPVI (Q9HCN6)
Platelet glycoprotein VI (GPVI) (Glycoprotein 6)
Gene: GP6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	11943772, 19940238, 1715582
Identification Methods	pull down, phage display, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0045121 - membrane raft
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 537 Hs			1 339
+	Mm
		56907 FYN_MOUSE (1-537): 0: 642: 99.44		PTPRF_MOUSE (1-332): 1.64e-52: 188: 14.67
+	Hs
		433481 YES_HUMAN (1-537): 0: 591: 71.61		GPVI_HUMAN (1-339): 2.78e-74: 234: 100.00
+	Hs
		442886 HCK_HUMAN (1-535): 0: 548: 56.64		GPVI_HUMAN (1-339): 2.78e-74: 234: 100.00
+	Hs
		434021 LYN_HUMAN (1-535): 0: 535: 54.48		GPVI_HUMAN (1-339): 2.78e-74: 234: 100.00
+	Hs
		411959 FYN_HUMAN (1-537): 0: 643: 100.00		PTPRF_HUMAN (112-324): 5.4e-27: 114: 14.41
+	Hs
		986398 BTK_HUMAN (5-531): 1.1e-153: 456: 31.02		GPVI_HUMAN (1-339): 2.78e-74: 234: 100.00
+	Hs
		411565 LCK_HUMAN (40-535): 0: 551: 57.60		PTPRF_HUMAN (112-324): 5.4e-27: 114: 14.41
+	Hs
		433581 LYN_HUMAN (1-535): 0: 535: 54.48		FCAR_HUMAN (109-306): 2.82e-26: 107: 17.39
+	Hs
		434111 LYN_HUMAN (1-535): 0: 535: 54.48		ROBO1_HUMAN (108-336): 7.89e-25: 107: 12.81
+	Hs
		434019 LYN_HUMAN (1-535): 0: 535: 54.48		ROBO2_HUMAN (7-249): 1.05e-12: 71.3: 14.44
+	Mm
		639452 LYN_MOUSE (1-535): 0: 535: 53.92		FCRL5_MOUSE (25-260): 8.91e-13: 70.8: 18.73
+	Mm
		435881 HCK_MOUSE (1-535): 0: 542: 56.45		LIRB3_MOUSE (20-128): 9.17e-09: 58.9: 24.39
+	Mm
		639442 LYN_MOUSE (1-535): 0: 535: 53.92		LIRB3_MOUSE (20-128): 9.17e-09: 58.9: 24.39
+	Dm
		219802 ABL_DROME (4-537): 3.97e-166: 513: 38.01		O44924_DROME (202-327): 1.04e-13: 74.3: 12.31