HitPredict

Interactor 1: KAPA (P06244)
cAMP-dependent protein kinase type 1 (PKA 1) (EC 2.7.11.11) (CDC25-suppressing protein kinase) (PK-25)
Gene: TPK1

Interactor 2: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37295430
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 397 Sc			1 705
+	Hs
		437900 KAPCB_HUMAN (44-397): 1.18e-150: 431: 45.20		HS90B_HUMAN (5-705): 0: 1022: 61.15
+	Hs
		437870 KAPCA_HUMAN (44-397): 2.33e-150: 430: 44.07		HS90B_HUMAN (5-705): 0: 1022: 61.15
+	Mm
		513660 AKT1_MOUSE (21-392): 5.41e-147: 427: 35.28		HS90B_MOUSE (5-705): 0: 1025: 61.57
+	Hs
		437928 AKT2_HUMAN (21-390): 5.43e-148: 429: 33.96		HS90B_HUMAN (5-705): 0: 1022: 61.15
+	Bt
		964601 AKT1_BOVIN (21-392): 2.31e-147: 428: 35.28		HS90B_BOVIN (5-705): 0: 1022: 61.15
+	Hs
		437898 KAPCG_HUMAN (44-397): 1.3e-148: 426: 41.81		HS90B_HUMAN (5-705): 0: 1022: 61.15
+	Hs
		437927 AKT1_HUMAN (21-392): 1.15e-146: 426: 35.01		HS90B_HUMAN (5-705): 0: 1022: 61.15
+	Hs
		431538 KAPCB_HUMAN (44-397): 1.18e-150: 431: 45.20		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Hs
		70435 B2RB89_HUMAN (44-397): 1.18e-150: 431: 45.20		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Hs
		431511 KAPCA_HUMAN (44-397): 2.33e-150: 430: 44.07		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Hs
		431573 AKT2_HUMAN (21-390): 5.43e-148: 429: 33.96		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Rn
		812703 AKT1_RAT (21-392): 6.23e-147: 426: 35.01		HS90A_RAT (4-705): 0: 1014: 60.59
+	Sc
		365554 KAPA_YEAST (1-397): 7.17e-166: 471: 100.00		HSP82_YEAST (1-705): 0: 968: 95.63
+	Hs
		431537 KAPCG_HUMAN (44-397): 1.3e-148: 426: 41.81		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Hs
		431572 AKT1_HUMAN (21-392): 1.15e-146: 426: 35.01		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Hs
		432376 AKT3_HUMAN (21-387): 7.1e-147: 426: 33.96		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Mm
		432411 AKT1_MOUSE (21-392): 5.41e-147: 427: 35.28		HS90A_MOUSE (4-705): 0: 1012: 60.59
+	Sc
		365544 KAPC_YEAST (1-397): 3.28e-152: 437: 73.37		HSP82_YEAST (1-705): 0: 968: 95.63
+	Hs
		538102 KAPCB_HUMAN (44-397): 1.18e-150: 431: 45.20		ENPL_HUMAN (3-680): 0: 893: 47.10
+	Hs
		538122 AKT1_HUMAN (21-392): 1.15e-146: 426: 35.01		ENPL_HUMAN (3-680): 0: 893: 47.10