Protein: DDR1
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)

Gene: DDR1
Organism: Homo sapiens
Interactions: 162
UniProt ID: Q08345

Gene Ontology (top 5):
GO:0001558 - regulation of cell growth
GO:0001952 - regulation of cell-matrix adhesion
GO:0004714 - transmembrane receptor protein tyrosine kinase activity
GO:0005518 - collagen binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1062975

CDC37
Hsp90 co-chaperone Cdc37

4

19

Small-scale

0.892

High

1062978

DDR2
Discoidin domain-containing receptor 2

2

20

High-throughput

0.811

High

1053651

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

20

Small-scale

0.789

High

711328

SHC1
SHC-transforming protein 1

2

20

Small-scale

0.777

High

710198

EPHA2
Ephrin type-A receptor 2

2

20

Small-scale

0.776

High

222067

NCK2
Cytoplasmic protein NCK2

2

20

Small-scale

0.769

High

699717

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

Small-scale

0.737

High

1062965

DDR1
Epithelial discoidin domain-containing receptor 1

2

19

Small-scale

0.712

High

572920

INSRR
Insulin receptor-related protein

1

19

High-throughput

0.691

High

788907

TGFR2
TGF-beta receptor type-2

1

19

High-throughput

0.691

High

1006895

KC1G2
Casein kinase I isoform gamma-2

1

20

High-throughput

0.691

High

1029596

CD83
CD83 antigen

1

2

High-throughput

0.691

High

1062966

AVR2B
Activin receptor type-2B

1

20

High-throughput

0.691

High

1063023

FLRT1
Leucine-rich repeat transmembrane protein FLRT1

1

20

High-throughput

0.691

High

136377

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

2

20

Small-scale

0.659

High

1062977

MK06
Mitogen-activated protein kinase 6

1

20

High-throughput

0.656

High

1062982

TIGIT
T-cell immunoreceptor with Ig and ITIM domains

1

0

High-throughput

0.656

High

163288

TR10B
Tumor necrosis factor receptor superfamily member 10B

2

18

High-throughput

0.628

High

463071

YES
Tyrosine-protein kinase Yes

1

19

Small-scale

0.625

High

410797

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.621

High

833406

RGS2
Regulator of G-protein signaling 2

2

3

High-throughput

0.620

High

1062980

CEA21
Cell adhesion molecule CEACAM21

1

12

High-throughput

0.618

High

1063029

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

17

High-throughput

0.618

High

461402

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

1062988

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.618

High

1063027

RAB21
Ras-related protein Rab-21

1

20

High-throughput

0.618

High

540005

BCR
Breakpoint cluster region protein

2

20

High-throughput

0.611

High

1062969

FLOT2
Flotillin-2

2

15

High-throughput

0.611

High

1063025

UBQL2
Ubiquilin-2

2

10

High-throughput

0.606

High

1010023

DLK1
Protein delta homolog 1

2

16

High-throughput

0.601

High

187344

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

19

Small-scale

0.575

High

440514

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.575

High

463479

LYN
Tyrosine-protein kinase Lyn

1

20

Small-scale

0.575

High

557257

SRC
Proto-oncogene tyrosine-protein kinase Src

1

19

Small-scale

0.575

High

582763

EZRI
Ezrin

1

20

Small-scale

0.575

High

593977

NCK1
SH2/SH3 adapter protein NCK1

1

20

Small-scale

0.575

High

619039

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

20

Small-scale

0.575

High

635712

RASA1
Ras GTPase-activating protein 1

1

20

Small-scale

0.575

High

767181

MERL
Merlin

1

20

Small-scale

0.575

High

772492

IRS1
Insulin receptor substrate 1

1

20

Small-scale

0.575

High

827759

STAT3
Signal transducer and activator of transcription 3

1

19

Small-scale

0.575

High

834182

CSK
Tyrosine-protein kinase CSK

1

20

Small-scale

0.575

High

855601

CRK
Adapter molecule crk

1

20

Small-scale

0.575

High

907266

STA5B
Signal transducer and activator of transcription 5B

1

19

Small-scale

0.575

High

913644

VAV2
Guanine nucleotide exchange factor VAV2

1

20

Small-scale

0.575

High

987583

GRB2
Growth factor receptor-bound protein 2

1

20

Small-scale

0.575

High

1062970

FLNC
Filamin-C

1

16

Small-scale

0.575

High

1062997

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

Small-scale

0.575

High

1063001

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

20

Small-scale

0.575

High

1063026

VAV3
Guanine nucleotide exchange factor VAV3

1

20

Small-scale

0.575

High

1063031

TLN1
Talin-1

1

20

Small-scale

0.575

High

857429

NOTC1
Neurogenic locus notch homolog protein 1

1

17

Small-scale

0.561

High

65342

TCAF2
TRPM8 channel-associated factor 2

1

1

High-throughput

0.536

High

139650

DLL1
Delta-like protein 1

1

9

High-throughput

0.536

High

165934

FFAR1
Free fatty acid receptor 1

1

12

High-throughput

0.536

High

225447

ITM2A
Integral membrane protein 2A

1

3

High-throughput

0.536

High

349410

TSN15
Tetraspanin-15

1

7

High-throughput

0.536

High

625995

ITIH2
Inter-alpha-trypsin inhibitor heavy chain H2

1

4

High-throughput

0.536

High

1022840

EFNB1
Ephrin-B1

1

2

High-throughput

0.536

High

1062967

KCNC3
Voltage-gated potassium channel KCNC3

1

8

High-throughput

0.536

High

1062990

T150A
Transmembrane protein 150A

1

1

High-throughput

0.536

High

1062991

TSN33
Tetraspanin-33

1

7

High-throughput

0.536

High

1062994

IZUM1
Izumo sperm-egg fusion protein 1

1

2

High-throughput

0.536

High

1063003

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

3

High-throughput

0.536

High

1063005

TSN17
Tetraspanin-17

1

5

High-throughput

0.536

High

1063006

MRAP2
Melanocortin-2 receptor accessory protein 2

1

2

High-throughput

0.536

High

1063010

OPALI
Opalin

1

1

High-throughput

0.536

High

1063012

SYT11
Synaptotagmin-11

1

8

High-throughput

0.536

High

1063013

PCDC1
Protocadherin alpha-C1

1

14

High-throughput

0.536

High

1063021

GPR83
G-protein coupled receptor 83

1

5

High-throughput

0.536

High

1063030

RNF11
RING finger protein 11

1

10

High-throughput

0.536

High

1063033

PCDA9
Protocadherin alpha-9

1

10

High-throughput

0.536

High

1063034

PCDA8
Protocadherin alpha-8

1

10

High-throughput

0.536

High

1063035

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

3

High-throughput

0.536

High

389817

TTHY
Transthyretin

1

0

High-throughput

0.518

High

719494

T4S1
Transmembrane 4 L6 family member 1

1

0

High-throughput

0.518

High

838076

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

19

Small-scale

0.514

High

1063000

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

20

Small-scale

0.514

High

139208

UPK2
Uroplakin-2

1

0

High-throughput

0.513

High

190347

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.513

High

749323

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.513

High

1062976

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.513

High

384144

CO1A1
Collagen alpha-1(I) chain

1

7

Small-scale

0.501

High

384285

CO3A1

1

7

Small-scale

0.501

High

465959

CO1A2
Collagen alpha-2(I) chain

1

7

Small-scale

0.501

High

1063004

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

8

High-throughput

0.494

High

1062992

T200A
Transmembrane protein 200A

1

1

High-throughput

0.489

High

1062998

KCNE4
Potassium voltage-gated channel subfamily E member 4

1

1

High-throughput

0.489

High

1063014

TM231
Transmembrane protein 231

1

1

High-throughput

0.489

High

1063015

MANS1
MANSC domain-containing protein 1

1

2

High-throughput

0.489

High

1063022

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.489

High

277660

H2AY
Core histone macro-H2A.1

1

6

High-throughput

0.479

High

424864

ADT2
ADP/ATP translocase 2

1

11

High-throughput

0.479

High

533653

CLUS
Clusterin

1

5

High-throughput

0.479

High

556039

CADH1
Cadherin-1

1

20

Small-scale

0.479

High

618247

CADH2
Cadherin-2

1

20

Small-scale

0.479

High

755693

MCM4
DNA replication licensing factor MCM4

1

7

Small-scale

0.479

High

933776

DRG2
Developmentally-regulated GTP-binding protein 2

1

4

Small-scale

0.479

High

957717

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

8

High-throughput

0.479

High

963407

STXB1
Syntaxin-binding protein 1

1

20

High-throughput

0.479

High

1062974

MSMO1
Methylsterol monooxygenase 1

1

2

High-throughput

0.479

High

1062984

F1711
Protein FAM171A1

1

18

High-throughput

0.479

High

1062993

AHNK2
Protein AHNAK2

1

5

High-throughput

0.479

High

1063002

RAD50
DNA repair protein RAD50

1

19

Small-scale

0.479

High

1063007

DDX27
Probable ATP-dependent RNA helicase DDX27

1

11

High-throughput

0.479

High

1063016

CYBP
Calcyclin-binding protein

1

3

High-throughput

0.479

High

1063018

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.479

High

1063024

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

5

High-throughput

0.479

High

352704

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

1

High-throughput

0.464

High

132793

PK3CD
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

1

20

Small-scale

0.445

High

230897

ORC5
Origin recognition complex subunit 5

1

1

Small-scale

0.445

High

279745

CISY
Citrate synthase, mitochondrial

1

2

Small-scale

0.445

High

390551

TFR1
Transferrin receptor protein 1

1

7

Small-scale

0.445

High

459561

PROF1
Profilin-1

1

1

Small-scale

0.445

High

571763

FPPS
Farnesyl pyrophosphate synthase

1

2

Small-scale

0.445

High

638150

ACOHC
Cytoplasmic aconitate hydratase

1

2

Small-scale

0.445

High

838995

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

20

Small-scale

0.445

High

839148

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

20

Small-scale

0.445

High

852735

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

8

Small-scale

0.445

High

1010290

BASP1
Brain acid soluble protein 1

1

2

Small-scale

0.445

High

1051997

CALD1
Caldesmon

1

20

Small-scale

0.445

High

1057678

TNR9
Tumor necrosis factor receptor superfamily member 9

1

16

High-throughput

0.445

High

1062971

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

4

Small-scale

0.445

High

1062973

PCH2
Pachytene checkpoint protein 2 homolog

1

13

Small-scale

0.445

High

1062999

PALLD
Palladin

1

20

Small-scale

0.445

High

1063008

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

14

Small-scale

0.445

High

1063028

VDAC3
Non-selective voltage-gated ion channel VDAC3

1

8

Small-scale

0.445

High

124769

AIP
AH receptor-interacting protein

1

17

High-throughput

0.437

High

184058

ACOX3
Peroxisomal acyl-coenzyme A oxidase 3

1

5

High-throughput

0.437

High

338321

SC24A
Protein transport protein Sec24A

1

20

High-throughput

0.437

High

338462

SC24B
Protein transport protein Sec24B

1

20

High-throughput

0.437

High

956142

SRP54
Signal recognition particle subunit SRP54

1

13

Small-scale

0.437

High

1017406

FOXK1
Forkhead box protein K1

1

4

High-throughput

0.437

High

1062983

ZN326
DBIRD complex subunit ZNF326

1

4

High-throughput

0.437

High

1062985

VIR
Protein virilizer homolog

1

1

High-throughput

0.437

High

1062986

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

7

High-throughput

0.437

High

1063011

CDCA3
Cell division cycle-associated protein 3

1

9

High-throughput

0.437

High

1063032

ZN451
E3 SUMO-protein ligase ZNF451

1

2

High-throughput

0.437

High

298560

O75942
Major prion protein

1

0

Small-scale

0.426

High

361793

PNPH
Purine nucleoside phosphorylase

1

0

Small-scale

0.426

High

406969

THY1
Thy-1 membrane glycoprotein

1

0

Small-scale

0.426

High

639375

5NTD
5'-nucleotidase

1

0

Small-scale

0.426

High

76376

B4DRL5
cDNA FLJ60834, highly similar to Engulfment and cell motility protein 2

1

1

Small-scale

0.407

High

674146

BRD2
Bromodomain-containing protein 2

1

7

Small-scale

0.407

High

854637

RAGP1
Ran GTPase-activating protein 1

1

20

Small-scale

0.407

High

936724

NP1L1
Nucleosome assembly protein 1-like 1

1

3

Small-scale

0.407

High

1062968

DCTN1
Dynactin subunit 1

1

10

Small-scale

0.407

High

1062972

BRD3
Bromodomain-containing protein 3

1

7

Small-scale

0.407

High

1062979

MIC60
MICOS complex subunit MIC60

1

3

Small-scale

0.407

High

1063009

MF14A
Hippocampus abundant transcript 1 protein

1

9

High-throughput

0.407

High

1063019

EVA1B
Protein eva-1 homolog B

2

0

High-throughput

0.313

High

333327

SNAPN
SNARE-associated protein Snapin

1

0

High-throughput

0.282

High

49521

SHSA3
Protein shisa-3 homolog

1

0

High-throughput

0.279

Low

1062981

SHSL1
Protein shisa-like-1

1

0

High-throughput

0.279

Low

1062987

CP054
Transmembrane protein C16orf54

1

0

High-throughput

0.279

Low

1062995

LSME2
Leucine-rich single-pass membrane protein 2

1

0

High-throughput

0.279

Low

1062996

MYCT1
Myc target protein 1

1

0

High-throughput

0.279

Low

1063017

SACA1
Sperm acrosome membrane-associated protein 1

1

0

High-throughput

0.279

Low

1063020

CLDN1
Claudin domain-containing protein 1

1

0

High-throughput

0.279

Low

1062989

BEND5
BEN domain-containing protein 5

1

0

High-throughput

0.238

Low

329737

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025