HitPredict

Interactor 1: PRGR (P06401)
Progesterone receptor (PR) (Nuclear receptor subfamily 3 group C member 3)
Gene: PGR

Interactor 2: NCOA3 (Q9Y6Q9)
Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)
Gene: NCOA3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	10757795, 19357364, 16728408
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	DUF4927~Hormone_recep, Hormone_recep~SRC-1
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 933 Hs			1 1424
+	Hs
		377843 GCR_HUMAN (256-933): 3.11e-99: 330: 33.82		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		487882 ANDR_HUMAN (122-933): 1.17e-97: 329: 29.70		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		414507 PRGR_HUMAN (1-933): 3.14e-133: 424: 100.00		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		914652 ERR3_HUMAN (472-917): 7.58e-103: 330: 23.54		HIF1A_HUMAN (1-829): 3.49e-114: 381: 14.72
+	Hs
		487482 ANDR_HUMAN (122-933): 1.17e-97: 329: 29.70		HIF1A_HUMAN (1-829): 3.49e-114: 381: 14.72
+	Hs
		414508 PRGR_HUMAN (1-933): 3.14e-133: 424: 100.00		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		487713 ANDR_HUMAN (122-933): 1.17e-97: 329: 29.70		NPAS2_HUMAN (19-807): 7.51e-111: 372: 16.20
+	Hs
		377346 GCR_HUMAN (256-933): 3.11e-99: 330: 33.82		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		126095 GCR_HUMAN (256-933): 3.11e-99: 330: 33.82		BMAL1_HUMAN (6-541): 4.9e-105: 349: 18.23
+	Hs
		487467 ANDR_HUMAN (122-933): 1.17e-97: 329: 29.70		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Mm
		580480 ANDR_MOUSE (98-933): 6.91e-93: 315: 28.88		NCOA2_MOUSE (1-1422): 1.73e-98: 349: 38.93
+	Mm
		914681 ERR3_MOUSE (472-917): 7.58e-103: 330: 23.54		EPAS1_MOUSE (12-872): 5.54e-91: 317: 13.77
+	Hs
		437642 MCR_HUMAN (12-933): 3.27e-105: 351: 29.16		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		377354 GCR_HUMAN (256-933): 3.11e-99: 330: 33.82		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		914651 ERR3_HUMAN (472-917): 7.58e-103: 330: 23.54		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		487473 ANDR_HUMAN (122-933): 1.17e-97: 329: 29.70		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		487150 ANDR_HUMAN (122-933): 1.17e-97: 329: 29.70		ARNT_HUMAN (6-642): 2.95e-76: 272: 16.01
+	Hs
		487185 ANDR_HUMAN (122-933): 1.17e-97: 329: 29.70		AHR_HUMAN (12-793): 4.1e-70: 255: 12.66
+	Mm
		864788 ERR3_MOUSE (472-917): 7.58e-103: 330: 23.54		ARNT_MOUSE (6-673): 3.97e-70: 254: 16.23
+	Hs
		487596 ANDR_HUMAN (122-933): 1.17e-97: 329: 29.70		KMT2C_HUMAN (471-1383): 2.87e-11: 70.9: 12.87