HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: H15 (P16401)
Histone H1.5 (Histone H1a) (Histone H1b) (Histone H1s-3)
Gene: H1-5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.744

Property	Details
Experiments	16205633, 18560763, 11980914, 23543736, 9668078, 8663071, 11516829
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0030261 - chromosome condensation
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 226
+	Rn
		413197 Q6P751_RAT (1-297): 3.89e-149: 421: 64.98		H1T_RAT (1-219): 2.4e-28: 107: 48.87
+	Hs
		559328 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		H13_HUMAN (1-184): 1.62e-22: 93.3: 68.48
+	Rn
		88903 Q6P751_RAT (1-297): 3.89e-149: 421: 64.98		H11_RAT (1-123): 2.62e-19: 84.4: 65.85
+	Hs
		558990 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		H15_HUMAN (1-118): 3.29e-18: 81.7: 100.00
+	Hs
		414717 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		H13_HUMAN (1-184): 1.62e-22: 93.3: 68.48
+	Hs
		625377 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		H11_HUMAN (1-186): 2.89e-15: 73.6: 61.29
+	Dm
		355225 CDK1_DROME (1-290): 2.24e-136: 389: 73.45		H1_DROME (2-225): 1.13e-26: 104: 32.89
+	Rn
		88899 CDK1_RAT (1-297): 4.18e-143: 406: 97.64		H11_RAT (1-123): 2.62e-19: 84.4: 65.85
+	Mm
		794656 CDK2_MOUSE (1-297): 2.06e-140: 401: 55.94		H15_MOUSE (39-205): 8.43e-21: 88.7: 92.81
+	Hs
		414874 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		H11_HUMAN (1-186): 2.89e-15: 73.6: 61.29
+	Mm
		509472 CDK1_MOUSE (1-297): 4.35e-142: 403: 96.97		H11_MOUSE (1-124): 1e-14: 72.1: 67.74
+	Mm
		794643 CDK2_MOUSE (1-297): 2.06e-140: 401: 55.94		H11_MOUSE (1-124): 1e-14: 72.1: 67.74
+	Mm
		509461 CDK1_MOUSE (1-297): 4.35e-142: 403: 96.97		H12_MOUSE (35-118): 7.25e-14: 69.8: 92.86
+	Mm
		550489 CDK2_MOUSE (1-297): 2.06e-140: 401: 55.94		H12_MOUSE (35-118): 7.25e-14: 69.8: 92.86
+	Hs
		559065 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		H15_HUMAN (1-118): 3.29e-18: 81.7: 100.00
+	Hs
		559654 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		H12_HUMAN (32-174): 1.09e-17: 80.2: 75.17
+	Hs
		489003 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		H14_HUMAN (1-118): 3.82e-17: 78.6: 87.29
+	Hs
		960270 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		H11_HUMAN (1-186): 2.89e-15: 73.6: 61.29
+	Mm
		794639 CDK5_MOUSE (1-293): 2.32e-134: 383: 56.12		H11_MOUSE (1-124): 1e-14: 72.1: 67.74