Protein: LSG1
Large subunit GTPase 1 homolog (hLsg1) (EC 3.6.5.-)

Gene: LSG1
Organism: Homo sapiens
Interactions: 170
UniProt ID: Q9H089

Gene Ontology (top 5):
GO:0000054 - ribosomal subunit export from nucleus
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005654 - nucleoplasm
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1429579

VAPA
Vesicle-associated membrane protein-associated protein A

5

1

High-throughput

0.720

High

333187

VAPB
Vesicle-associated membrane protein-associated protein B/C

5

1

High-throughput

0.716

High

1429588

DRG1
Developmentally-regulated GTP-binding protein 1

1

6

High-throughput

0.691

High

386211

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

3

4

High-throughput

0.640

High

1065025

FGL1
Fibrinogen-like protein 1

4

1

High-throughput

0.630

High

1138619

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.618

High

1348908

PLPR1
Phospholipid phosphatase-related protein type 1

2

0

High-throughput

0.585

High

373104

MYC
Myc proto-oncogene protein

2

7

High-throughput

0.584

High

396905

ESR1
Estrogen receptor

2

10

High-throughput

0.571

High

1383057

LRC59
Leucine-rich repeat-containing protein 59

2

0

High-throughput

0.559

High

1332392

TTC29
Tetratricopeptide repeat protein 29

2

1

High-throughput

0.558

High

141096

NOP56
Nucleolar protein 56

1

7

High-throughput

0.536

High

303631

SRP72
Signal recognition particle subunit SRP72

1

4

High-throughput

0.536

High

414584

P53
Cellular tumor antigen p53

1

3

High-throughput

0.536

High

479473

SRP19
Signal recognition particle 19 kDa protein

1

2

High-throughput

0.536

High

542644

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

687297

HMGB2
High mobility group protein B2

1

7

High-throughput

0.536

High

693968

RL10
Large ribosomal subunit protein uL16

1

5

High-throughput

0.536

High

785434

RL4
Large ribosomal subunit protein uL4

1

9

High-throughput

0.536

High

859446

RL5
Large ribosomal subunit protein uL18

1

5

High-throughput

0.536

High

884228

SRP09
Signal recognition particle 9 kDa protein

1

2

High-throughput

0.536

High

897075

MAP2
Methionine aminopeptidase 2

1

5

High-throughput

0.536

High

970097

RS16
Small ribosomal subunit protein uS9

1

4

High-throughput

0.536

High

985874

RL11
Large ribosomal subunit protein uL5

1

7

High-throughput

0.536

High

1016217

RL19
Large ribosomal subunit protein eL19

1

5

High-throughput

0.536

High

1360472

PSPC1
Paraspeckle component 1

1

5

High-throughput

0.536

High

1429573

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.536

High

1429585

SRP68
Signal recognition particle subunit SRP68

1

3

High-throughput

0.536

High

1429587

ALK
ALK tyrosine kinase receptor

2

6

High-throughput

0.533

High

216812

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.513

High

567481

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.513

High

948585

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

1429578

PEN2
Gamma-secretase subunit PEN-2

1

0

High-throughput

0.513

High

437337

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.493

High

48780

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.479

High

126789

RHOD
Rho-related GTP-binding protein RhoD

1

9

High-throughput

0.479

High

129408

MEN1
Menin

1

2

High-throughput

0.479

High

174083

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

188993

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.479

High

242864

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

291530

NU155
Nuclear pore complex protein Nup155

1

2

High-throughput

0.479

High

346304

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

14

High-throughput

0.479

High

401456

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

418424

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

466449

RHOC
Rho-related GTP-binding protein RhoC

1

6

High-throughput

0.479

High

473068

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.479

High

488859

FURIN
Furin

1

1

High-throughput

0.479

High

541677

FGFR1
Fibroblast growth factor receptor 1

1

7

High-throughput

0.479

High

631461

RAB5A
Ras-related protein Rab-5A

1

1

High-throughput

0.479

High

634623

LMNB1
Lamin-B1

1

4

High-throughput

0.479

High

644043

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

2

High-throughput

0.479

High

699100

CALX
Calnexin

1

1

High-throughput

0.479

High

891310

GSK3A
Glycogen synthase kinase-3 alpha

1

2

High-throughput

0.479

High

891778

GSK3B
Glycogen synthase kinase-3 beta

1

3

High-throughput

0.479

High

905121

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.479

High

941261

IF6
Eukaryotic translation initiation factor 6

1

5

High-throughput

0.479

High

951409

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

962460

RHOA
Transforming protein RhoA

1

7

High-throughput

0.479

High

971055

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

981078

H2B1C
Histone H2B type 1-C/E/F/G/I

1

6

High-throughput

0.479

High

1005079

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

1015764

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.479

High

1049761

1433F
14-3-3 protein eta

1

1

High-throughput

0.479

High

1058641

CKAP4
Cytoskeleton-associated protein 4

1

2

High-throughput

0.479

High

1067698

EP300
Histone acetyltransferase p300

1

7

High-throughput

0.479

High

1087273

STX4
Syntaxin-4

1

2

High-throughput

0.479

High

1107191

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1125648

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

1

High-throughput

0.479

High

1138032

TNIP1
TNFAIP3-interacting protein 1

1

7

High-throughput

0.479

High

1235517

IFIX
Pyrin and HIN domain-containing protein 1

1

5

High-throughput

0.479

High

1245127

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.479

High

1251347

DJC14
DnaJ homolog subfamily C member 14

1

2

High-throughput

0.479

High

1289611

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

1312249

MIRO2
Mitochondrial Rho GTPase 2

1

9

High-throughput

0.479

High

1329858

SIR6
NAD-dependent protein deacylase sirtuin-6

1

3

High-throughput

0.479

High

1330926

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.479

High

1337664

PDZD8
PDZ domain-containing protein 8

1

1

High-throughput

0.479

High

1352364

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.479

High

1352740

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.479

High

1367225

ESR2
Estrogen receptor beta

1

9

High-throughput

0.479

High

1381066

ZN622
Cytoplasmic 60S subunit biogenesis factor ZNF622

1

2

High-throughput

0.479

High

1387227

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

1

High-throughput

0.479

High

1393676

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

1395933

DNJC1
DnaJ homolog subfamily C member 1

1

11

High-throughput

0.479

High

1401222

PANX1
Pannexin-1

1

1

High-throughput

0.479

High

1405136

DNJC2
DnaJ homolog subfamily C member 2

1

5

High-throughput

0.479

High

1412655

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.479

High

1429565

DHX36
ATP-dependent DNA/RNA helicase DHX36

1

8

High-throughput

0.479

High

1429569

SP110
Sp110 nuclear body protein

1

10

High-throughput

0.479

High

1429570

ANLN
Anillin

1

3

High-throughput

0.479

High

1429576

TBA8
Tubulin alpha-8 chain

1

1

High-throughput

0.479

High

1429583

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1429584

SEC63
Translocation protein SEC63 homolog

1

2

High-throughput

0.479

High

1429586

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

1429594

RBM8A
RNA-binding protein 8A

1

3

High-throughput

0.479

High

1429562

DJC25
DnaJ homolog subfamily C member 25

1

7

High-throughput

0.470

High

164437

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

178656

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.458

High

248623

FADS1
Acyl-CoA

1

0

High-throughput

0.458

High

417738

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

611335

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

0

High-throughput

0.458

High

643062

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

703056

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

837829

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

847681

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

880679

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

895042

EMD
Emerin

1

0

High-throughput

0.458

High

902056

RAB9A
Ras-related protein Rab-9A

1

0

High-throughput

0.458

High

904111

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

958020

RAB14
Ras-related protein Rab-14

1

0

High-throughput

0.458

High

1004191

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.458

High

1027173

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.458

High

1045748

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1111693

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

1287439

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

0

High-throughput

0.458

High

1309883

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.458

High

1331249

ARL10
ADP-ribosylation factor-like protein 10

1

0

High-throughput

0.458

High

1333988

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.458

High

1404193

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1414443

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1421121

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1429563

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.458

High

1429567

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1429568

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

1429571

PXMP2
Peroxisomal membrane protein 2

1

0

High-throughput

0.458

High

1429572

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

1429575

S39A1
Zinc transporter ZIP1

1

0

High-throughput

0.458

High

1429577

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

1429580

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

1429582

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

1429591

FIS1
Mitochondrial fission 1 protein

1

0

High-throughput

0.458

High

1429592

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

430343

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

1056960

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

High-throughput

0.445

High

1064024

ECHP
Peroxisomal bifunctional enzyme

1

1

High-throughput

0.445

High

1132431

CASP8
Caspase-8

1

1

High-throughput

0.445

High

189825

STX7
Syntaxin-7

1

2

High-throughput

0.437

High

294306

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

412581

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.437

High

710754

EPHA8
Ephrin type-A receptor 8

1

3

High-throughput

0.437

High

1024828

VIGLN
Vigilin

1

4

High-throughput

0.437

High

1034336

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

7

High-throughput

0.437

High

1157060

NTRK3
NT-3 growth factor receptor

1

7

High-throughput

0.437

High

1207197

CF157
Cilia- and flagella-associated protein 157

1

3

High-throughput

0.437

High

1255462

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1276763

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.437

High

1286898

TM11B
Transmembrane protease serine 11B

1

1

High-throughput

0.437

High

1360932

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

1397160

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

5

High-throughput

0.437

High

1429566

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1429574

OTULL
Inactive ubiquitin thioesterase OTULINL

1

1

High-throughput

0.437

High

1429581

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

4

High-throughput

0.437

High

1429589

DJC16
DnaJ homolog subfamily C member 16

1

2

High-throughput

0.437

High

1429593

MAFB
Transcription factor MafB

1

4

High-throughput

0.437

High

1429595

DJC15
DnaJ homolog subfamily C member 15

1

1

High-throughput

0.437

High

1313832

S15A3
Solute carrier family 15 member 3

1

0

High-throughput

0.426

High

169208

QCR10
Cytochrome b-c1 complex subunit 10

1

0

High-throughput

0.279

Low

694395

CO8A1
Collagen alpha-1(VIII) chain

1

0

High-throughput

0.279

Low

1196245

GAG2E
G antigen 2E

1

0

High-throughput

0.279

Low

1218121

CP141
Cilia- and flagella-associated protein 141

1

0

High-throughput

0.279

Low

1403418

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.279

Low

1429596

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.279

Low

482698

SPRC
SPARC

1

0

High-throughput

0.269

Low

1147678

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

High-throughput

0.249

Low

1210529

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.249

Low

1322978

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

1382937

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1429564

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low

653562

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

1429590

S27A6
Long-chain fatty acid transport protein 6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025