HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: HMGB2 (P26583)
High mobility group protein B2 (High mobility group protein 2) (HMG-2)
Gene: HMGB2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0010629 - negative regulation of gene expression
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 209
+	Hs
		449545 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		HMGB1_HUMAN (1-174): 3.53e-42: 143: 86.21
+	Hs
		625125 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		HMGB2_HUMAN (1-187): 3.05e-41: 140: 100.00
+	Hs
		414690 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		HMGB1_HUMAN (1-174): 3.53e-42: 143: 86.21
+	Hs
		643326 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		HMGB2_HUMAN (1-187): 3.05e-41: 140: 100.00
+	Hs
		414863 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		TFAM_HUMAN (9-190): 7.47e-31: 114: 21.68
+	Hs
		414816 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		SOX2_HUMAN (3-94): 2.29e-23: 96.7: 22.83
+	Hs
		567641 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		UBF1_HUMAN (10-158): 1.47e-09: 58.9: 24.72
+	Hs
		415030 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		CIC_HUMAN (3-100): 1.66e-11: 64.7: 22.45