Protein: CFLAR
CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]

Gene: CFLAR
Organism: Homo sapiens
Interactions: 91
UniProt ID: O15519

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0005123 - death receptor binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006508 - proteolysis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

181615

CASP8
Caspase-8

28

18

Small-scale

0.993

High

181608

FADD
FAS-associated death domain protein

13

16

Small-scale

0.981

High

181628

CASPA
Caspase-10

5

18

Small-scale

0.932

High

181577

RAF1
RAF proto-oncogene serine/threonine-protein kinase

3

3

Small-scale

0.850

High

181575

DEDD
Death effector domain-containing protein

3

5

Small-scale

0.834

High

181591

CASP3
Caspase-3

2

17

Small-scale

0.783

High

181571

CFLAR
CASP8 and FADD-like apoptosis regulator

2

17

Small-scale

0.757

High

181627

DEDD2
DNA-binding death effector domain-containing protein 2

2

5

Small-scale

0.746

High

181634

ITCH
E3 ubiquitin-protein ligase Itchy homolog

8

3

Small-scale

0.741

High

181612

BIRC3
Baculoviral IAP repeat-containing protein 3

1

20

Small-scale

0.724

High

181606

TRAF1
TNF receptor-associated factor 1

5

18

Small-scale

0.718

High

181588

TNR6
Tumor necrosis factor receptor superfamily member 6

6

16

Small-scale

0.717

High

181613

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

5

8

Small-scale

0.714

High

181595

TNF10
Tumor necrosis factor ligand superfamily member 10

6

13

Small-scale

0.714

High

154283

TR10B
Tumor necrosis factor receptor superfamily member 10B

5

16

Small-scale

0.702

High

121422

TR10A
Tumor necrosis factor receptor superfamily member 10A

5

16

Small-scale

0.699

High

181629

MIB2
E3 ubiquitin-protein ligase MIB2

1

0

Small-scale

0.687

High

181605

TRAF2
TNF receptor-associated factor 2

4

19

Small-scale

0.676

High

181601

PLIN5
Perilipin-5

3

2

High-throughput

0.667

High

181636

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

7

Small-scale

0.665

High

181589

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

2

4

Small-scale

0.634

High

153041

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

9

Small-scale

0.618

High

181584

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

2

Small-scale

0.618

High

181592

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

12

Small-scale

0.618

High

181602

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

11

Small-scale

0.618

High

181637

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

7

Small-scale

0.618

High

181578

P53
Cellular tumor antigen p53

2

5

Small-scale

0.584

High

181651

CHIP
E3 ubiquitin-protein ligase CHIP

2

3

Small-scale

0.584

High

181576

RNF8
E3 ubiquitin-protein ligase RNF8

1

5

Small-scale

0.561

High

181641

TRI31
E3 ubiquitin-protein ligase TRIM31

1

2

Small-scale

0.561

High

181647

RNF12
E3 ubiquitin-protein ligase RLIM

1

3

Small-scale

0.561

High

181600

SMAD3
Mothers against decapentaplegic homolog 3

1

1

High-throughput

0.541

High

181623

MEX3B
RNA-binding protein MEX3B

1

0

Small-scale

0.537

High

181611

SKP2
S-phase kinase-associated protein 2

1

2

Small-scale

0.527

High

181614

CUL1
Cullin-1

1

5

Small-scale

0.527

High

181572

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

7

Small-scale

0.515

High

181573

DOK2
Docking protein 2

1

3

High-throughput

0.515

High

181609

CBLB
E3 ubiquitin-protein ligase CBL-B

1

1

Small-scale

0.515

High

181617

SF3B3
Splicing factor 3B subunit 3

1

2

High-throughput

0.515

High

181644

ATG3
Ubiquitin-like-conjugating enzyme ATG3

1

1

Small-scale

0.515

High

181631

NEUL3
E3 ubiquitin-protein ligase NEURL3

1

8

Small-scale

0.512

High

181599

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.505

High

181620

SPAS1
Spermatogenesis-associated serine-rich protein 1

1

1

High-throughput

0.494

High

181648

DAXX
Death domain-associated protein 6

1

0

Small-scale

0.493

High

124676

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

6

High-throughput

0.479

High

153496

ANM5
Protein arginine N-methyltransferase 5

1

1

Small-scale

0.479

High

181579

GELS
Gelsolin

1

2

Small-scale

0.479

High

181580

HS90A
Heat shock protein HSP 90-alpha

1

1

Small-scale

0.479

High

181586

ERBB3
Receptor tyrosine-protein kinase erbB-3

1

5

Small-scale

0.479

High

181593

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

13

Small-scale

0.479

High

181594

EFTU
Elongation factor Tu, mitochondrial

1

2

High-throughput

0.479

High

181596

EPIPL
Epiplakin

1

1

High-throughput

0.479

High

181603

B2CL1
Bcl-2-like protein 1

1

8

Small-scale

0.479

High

181604

EP300
Histone acetyltransferase p300

1

5

Small-scale

0.479

High

181607

TRAF3
TNF receptor-associated factor 3

1

20

Small-scale

0.479

High

181616

Q15156
PML-RAR protein

1

5

Small-scale

0.479

High

181621

Q53FC7
Heat shock 70kDa protein 6

1

3

High-throughput

0.479

High

181622

Q6PK50
Heat shock protein HSP 90-beta

1

2

High-throughput

0.479

High

181625

TCAM1
TIR domain-containing adapter molecule 1

1

1

Small-scale

0.479

High

181632

RNF31
E3 ubiquitin-protein ligase RNF31

1

6

Small-scale

0.479

High

181638

ANM1
Protein arginine N-methyltransferase 1

1

1

Small-scale

0.479

High

181642

ZBP1
Z-DNA-binding protein 1

1

1

Small-scale

0.479

High

181646

UBP40
Ubiquitin carboxyl-terminal hydrolase 40

1

2

Small-scale

0.479

High

181650

FKBPL
FK506-binding protein-like

1

1

High-throughput

0.479

High

181652

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

20

Small-scale

0.479

High

181653

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

3

High-throughput

0.479

High

181654

GMEB1
Glucocorticoid modulatory element-binding protein 1

1

2

Small-scale

0.479

High

73104

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

0

High-throughput

0.458

High

181581

XRCC6
X-ray repair cross-complementing protein 6

1

0

Small-scale

0.458

High

181582

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.458

High

181583

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

0

High-throughput

0.458

High

181597

RS29
Small ribosomal subunit protein uS14

1

0

High-throughput

0.458

High

181610

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.458

High

181618

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.458

High

181619

FSCN1
Fascin

1

0

High-throughput

0.458

High

181624

DTX1
E3 ubiquitin-protein ligase DTX1

1

0

Small-scale

0.458

High

181626

NUDC3
NudC domain-containing protein 3

1

0

High-throughput

0.458

High

181633

STALP
AMSH-like protease

1

0

Small-scale

0.458

High

181640

AASD1
Alanyl-tRNA editing protein Aarsd1

1

0

High-throughput

0.458

High

181643

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

181585

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

1

High-throughput

0.445

High

181574

SF3B1
Splicing factor 3B subunit 1

1

1

High-throughput

0.437

High

181630

Q96BE0
Heat shock cognate 71 kDa protein

1

4

High-throughput

0.437

High

181639

Q9BPW0
Serine/threonine-protein phosphatase

1

3

High-throughput

0.437

High

181598

RBX1
E3 ubiquitin-protein ligase RBX1

1

3

Small-scale

0.408

High

181587

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.249

Low

181590

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.249

Low

181635

RADIL
Ras-associating and dilute domain-containing protein

1

0

High-throughput

0.249

Low

181645

SEP11
Septin-11

1

0

High-throughput

0.249

Low

181649

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024