Protein: HACD2
Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 (EC 4.2.1.134) (3-hydroxyacyl-CoA dehydratase 2) (HACD2) (Protein-tyrosine phosphatase-like member B)

Gene: HACD2
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q6Y1H2

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0018812 - 3-hydroxyacyl-CoA dehydratase activity
GO:0019899 - enzyme binding
GO:0030148 - sphingolipid biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1251315

TECR
Very-long-chain enoyl-CoA reductase

5

1

High-throughput

0.721

High

1242831

S39A4
Zinc transporter ZIP4

3

1

High-throughput

0.609

High

733006

VIPR1
Vasoactive intestinal polypeptide receptor 1

3

3

High-throughput

0.604

High

1251299

LPAR1
Lysophosphatidic acid receptor 1

3

3

High-throughput

0.593

High

903967

BAP31
B-cell receptor-associated protein 31

1

1

Small-scale

0.582

High

1251302

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

0

High-throughput

0.580

High

1251317

TMX2
Thioredoxin-related transmembrane protein 2

2

0

High-throughput

0.580

High

1251304

BSCL2
Seipin

2

0

High-throughput

0.576

High

669014

FPR2
N-formyl peptide receptor 2

2

4

High-throughput

0.574

High

669229

NK1R
Substance-P receptor

2

2

High-throughput

0.574

High

771157

APJ
Apelin receptor

2

2

High-throughput

0.574

High

835301

VIPR2
Vasoactive intestinal polypeptide receptor 2

2

3

High-throughput

0.574

High

845056

EAA3
Excitatory amino acid transporter 3

2

1

High-throughput

0.574

High

1153261

AAAT
Neutral amino acid transporter B(0)

2

1

High-throughput

0.574

High

1159069

C3AR
C3a anaphylatoxin chemotactic receptor

2

4

High-throughput

0.574

High

1251295

SPP2B
Signal peptide peptidase-like 2B

2

1

High-throughput

0.574

High

1251310

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

2

3

High-throughput

0.574

High

396371

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

173964

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

4

High-throughput

0.536

High

595069

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

2

High-throughput

0.536

High

926793

VMAT1
Chromaffin granule amine transporter

1

6

High-throughput

0.536

High

1251301

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

4

High-throughput

0.536

High

399586

VTNC
Vitronectin

1

0

High-throughput

0.513

High

1251307

S26A6
Solute carrier family 26 member 6

1

0

High-throughput

0.513

High

508161

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

133270

P2Y10
Putative P2Y purinoceptor 10

1

5

High-throughput

0.489

High

182611

GP182
G-protein coupled receptor 182

1

5

High-throughput

0.489

High

832420

OPRX
Nociceptin receptor

1

2

High-throughput

0.489

High

848508

MAGA8
Melanoma-associated antigen 8

1

1

High-throughput

0.489

High

867977

GLR
Glucagon receptor

1

3

High-throughput

0.489

High

880163

PTH2R
Parathyroid hormone 2 receptor

1

3

High-throughput

0.489

High

937041

CASP6
Caspase-6

1

1

High-throughput

0.489

High

1053021

VMAT2
Synaptic vesicular amine transporter

1

2

High-throughput

0.489

High

1101542

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

4

High-throughput

0.489

High

1238991

NIPA3
Magnesium transporter NIPA3

1

1

High-throughput

0.489

High

1251308

S22A4
Solute carrier family 22 member 4

1

3

High-throughput

0.489

High

1251311

TTYH1
Protein tweety homolog 1

1

1

High-throughput

0.489

High

1251313

AT133
Polyamine-transporting ATPase 13A3

1

5

High-throughput

0.489

High

414061

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

581128

RAC2
Ras-related C3 botulinum toxin substrate 2

1

8

High-throughput

0.479

High

698791

CALX
Calnexin

1

1

High-throughput

0.479

High

953520

RAC3
Ras-related C3 botulinum toxin substrate 3

1

8

High-throughput

0.479

High

962187

RHOA
Transforming protein RhoA

1

10

High-throughput

0.479

High

1248955

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1251289

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

4

High-throughput

0.479

High

1251300

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

1116631

I10R1
Interleukin-10 receptor subunit alpha

1

1

High-throughput

0.470

High

303242

S22A5
Organic cation/carnitine transporter 2

1

3

High-throughput

0.445

High

563953

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

1251309

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.445

High

218354

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

293896

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

1228422

FTM
Protein fantom

1

1

High-throughput

0.437

High

1238716

TECT3
Tectonic-3

1

3

High-throughput

0.437

High

1251287

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

1251297

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.437

High

1251305

TECT2
Tectonic-2

1

3

High-throughput

0.437

High

1251312

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

722498

CTR1
High affinity cationic amino acid transporter 1

1

2

High-throughput

0.407

High

867635

GPR12
G-protein coupled receptor 12

1

3

High-throughput

0.407

High

870367

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

3

High-throughput

0.407

High

1139465

S39AE
Metal cation symporter ZIP14

1

1

High-throughput

0.407

High

1211919

S35F1
Solute carrier family 35 member F1

1

1

High-throughput

0.407

High

1251291

S22A9
Organic anion transporter 7

1

3

High-throughput

0.407

High

1251318

FLVC1
Choline/ethanolamine transporter FLVCR1

1

2

High-throughput

0.407

High

219319

B4GA1
Beta-1,4-glucuronyltransferase 1

2

0

High-throughput

0.328

High

1251296

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

2

0

High-throughput

0.328

High

1251314

IPPK
Inositol-pentakisphosphate 2-kinase

2

0

High-throughput

0.328

High

74169

SMIM1
Small integral membrane protein 1

2

0

High-throughput

0.316

High

1207528

F209A
Protein FAM209A

2

0

High-throughput

0.316

High

288278

SPAG6
Sperm-associated antigen 6

1

0

High-throughput

0.279

Low

818874

ADCY8
Adenylate cyclase type 8

1

0

High-throughput

0.279

Low

868092

AL1A3
Retinaldehyde dehydrogenase 3

1

0

High-throughput

0.279

Low

880844

NRAM2
Natural resistance-associated macrophage protein 2

1

0

High-throughput

0.279

Low

1251290

PB1
Protein polybromo-1

1

0

High-throughput

0.279

Low

1251292

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1251293

IT70B
Intraflagellar transport protein 70B

1

0

High-throughput

0.279

Low

1251298

SFT2A
Vesicle transport protein SFT2A

1

0

High-throughput

0.279

Low

1251303

ORAI1
Calcium release-activated calcium channel protein 1

1

0

High-throughput

0.279

Low

1251306

OPALI
Opalin

1

0

High-throughput

0.279

Low

227597

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

358716

LDHA
L-lactate dehydrogenase A chain

1

0

High-throughput

0.249

Low

455980

ASGR2
Asialoglycoprotein receptor 2

1

0

High-throughput

0.249

Low

248894

GSDME
Gasdermin-E

1

0

High-throughput

0.232

Low

469506

SYPH
Synaptophysin

1

0

High-throughput

0.232

Low

1236192

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

1246078

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

0

High-throughput

0.232

Low

1251288

S35E3
Solute carrier family 35 member E3

1

0

High-throughput

0.232

Low

1251294

ZNT7
Zinc transporter 7

1

0

High-throughput

0.232

Low

1251316

S23A1
Solute carrier family 23 member 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025