HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: UBP14 (P54578)
Ubiquitin carboxyl-terminal hydrolase 14 (EC 3.4.19.12) (Deubiquitinating enzyme 14) (Ubiquitin thioesterase 14) (Ubiquitin-specific-processing protease 14)
Gene: USP14

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	30425250, 36604147
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 494
+	Hs
		415107 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		UBP22_HUMAN (66-487): 1.12e-91: 290: 19.03
+	Dm
		820731 CDK5_DROME (1-289): 4.62e-131: 375: 54.48		UBP2_DROME (31-482): 5.35e-89: 293: 19.40
+	Dm
		618454 CDK2_DROME (1-290): 5.77e-129: 371: 55.52		UBP2_DROME (31-482): 5.35e-89: 293: 19.40
+	Dm
		820763 CDK5_DROME (1-289): 4.62e-131: 375: 54.48		X2JLM6_DROME (31-482): 6.68e-90: 287: 19.40
+	Dm
		618494 CDK2_DROME (1-290): 5.77e-129: 371: 55.52		X2JLM6_DROME (31-482): 6.68e-90: 287: 19.40
+	Sc
		565662 PHO85_YEAST (3-295): 4.36e-130: 373: 49.17		UBP6_YEAST (4-481): 1.15e-88: 282: 30.10
+	Hs
		960423 CDK16_HUMAN (1-297): 6.03e-124: 364: 51.68		UBP21_HUMAN (29-486): 4.53e-88: 282: 16.80