HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: CDC20 (Q12834)
Cell division cycle protein 20 homolog (p55CDC)
Gene: CDC20

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	28514442, 10799291, 26912231, 36001690
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0051301 - cell division
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 499
+	Hs
		625397 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		CDC20_HUMAN (1-499): 1.18e-136: 405: 100.00
+	Hs
		625543 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		FBXW7_HUMAN (210-496): 2.2e-71: 242: 17.81
+	Hs
		415016 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		FBXW7_HUMAN (210-496): 2.2e-71: 242: 17.81
+	Hs
		625202 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		LIS1_HUMAN (337-498): 1.74e-37: 143: 16.56
+	Hs
		414806 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		LIS1_HUMAN (337-498): 1.74e-37: 143: 16.56
+	Sc
		565470 PHO85_YEAST (3-295): 4.36e-130: 373: 49.17		NLE1_YEAST (63-336): 4.61e-43: 161: 17.34
+	Hs
		625637 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		FZR1_HUMAN (315-495): 1.51e-24: 108: 19.02
+	Sc
		339740 CDK1_YEAST (3-289): 1.25e-128: 369: 60.14		AMA1_YEAST (162-470): 1.12e-38: 150: 28.65
+	Hs
		415103 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		FZR1_HUMAN (315-495): 1.51e-24: 108: 19.02
+	Hs
		960344 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		FZR1_HUMAN (315-495): 1.51e-24: 108: 19.02
+	At
		621673 CDKA1_ARATH (1-290): 1.2e-137: 392: 67.01		FZR2_ARATH (315-495): 1.1e-20: 96.6: 18.03
+	At
		621683 CDKA1_ARATH (1-290): 1.2e-137: 392: 67.01		FZR1_ARATH (315-495): 5.69e-19: 91.6: 20.22
+	At
		621679 CDKA1_ARATH (1-290): 1.2e-137: 392: 67.01		FZR3_ARATH (313-495): 2.14e-18: 89.6: 17.30
+	Sc
		339758 CDK1_YEAST (3-289): 1.25e-128: 369: 60.14		CDH1_YEAST (315-495): 4.18e-17: 86.2: 12.57
+	Dm
		618423 CDK1_DROME (1-290): 2.24e-136: 389: 73.45		Q9W4H9_DROME (395-496): 6.69e-10: 63: 15.39
+	Sc
		339473 CDK1_YEAST (3-289): 1.25e-128: 369: 60.14		CDC20_YEAST (315-495): 5.18e-14: 76.6: 18.13