Protein: P63
Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51)

Gene: P63, TP63
Organism: Homo sapiens
Interactions: 179
UniProt ID: Q9H3D4

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

186805

P73
Tumor protein p73

7

14

Small-scale

0.960

High

414610

P53
Cellular tumor antigen p53

6

14

Small-scale

0.931

High

1432524

P63
Tumor protein 63

4

14

Small-scale

0.902

High

1394609

ITCH
E3 ubiquitin-protein ligase Itchy homolog

6

15

Small-scale

0.738

High

1067713

EP300
Histone acetyltransferase p300

4

20

Small-scale

0.705

High

1419855

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

7

Small-scale

0.691

High

1396261

ASPP1
Apoptosis-stimulating of p53 protein 1

1

16

Small-scale

0.681

High

1028391

MDM2
E3 ubiquitin-protein ligase Mdm2

4

10

Small-scale

0.680

High

862454

YAP1
Transcriptional coactivator YAP1

3

20

Small-scale

0.658

High

1109388

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

3

3

Small-scale

0.653

High

1406844

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

2

9

Small-scale

0.649

High

1115609

ASPP2
Apoptosis-stimulating of p53 protein 2

1

16

Small-scale

0.647

High

1356645

IASPP
RelA-associated inhibitor

1

15

Small-scale

0.647

High

1432533

DAXX
Death domain-associated protein 6

2

4

Small-scale

0.633

High

355032

CHK2
Serine/threonine-protein kinase Chk2

2

6

High-throughput

0.628

High

1017488

FOXK1
Forkhead box protein K1

2

13

High-throughput

0.628

High

1029755

FOXK2
Forkhead box protein K2

2

11

High-throughput

0.628

High

1384263

SH3K1
SH3 domain-containing kinase-binding protein 1

2

1

High-throughput

0.628

High

992959

RACK1
Small ribosomal subunit protein RACK1

2

6

Small-scale

0.627

High

993746

UBC9
SUMO-conjugating enzyme UBC9

2

8

Small-scale

0.625

High

1430203

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

2

15

Small-scale

0.624

High

626361

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

11

Small-scale

0.618

High

1257298

STXB4
Syntaxin-binding protein 4

1

3

Small-scale

0.618

High

943815

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

1

High-throughput

0.606

High

1390440

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

2

3

High-throughput

0.606

High

1369207

KAT2B
Histone acetyltransferase KAT2B

2

15

Small-scale

0.602

High

278960

PEX14
Peroxisomal membrane protein PEX14

2

0

High-throughput

0.602

High

1432543

RP3A
Rabphilin-3A

2

0

High-throughput

0.602

High

1432541

FBW1A
F-box/WD repeat-containing protein 1A

1

6

Small-scale

0.589

High

808170

CDN1A
Cyclin-dependent kinase inhibitor 1

2

4

Small-scale

0.584

High

872742

SOX2
Transcription factor SOX-2

2

8

Small-scale

0.584

High

1153909

SMAD2
Mothers against decapentaplegic homolog 2

2

4

Small-scale

0.584

High

1390163

MCRS1
Microspherule protein 1

2

0

High-throughput

0.580

High

1086908

CDC20
Cell division cycle protein 20 homolog

1

8

Small-scale

0.578

High

1432539

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

Small-scale

0.578

High

1432268

HIPK2
Homeodomain-interacting protein kinase 2

2

14

Small-scale

0.576

High

1401112

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

6

High-throughput

0.575

High

1110910

TDG
G/T mismatch-specific thymine DNA glycosylase

1

2

Small-scale

0.573

High

617184

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

8

Small-scale

0.561

High

714421

PML
Protein PML

1

16

Small-scale

0.561

High

842861

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

12

Small-scale

0.561

High

1399848

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

3

Small-scale

0.561

High

250827

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

6

Small-scale

0.554

High

775311

FUS
RNA-binding protein FUS

1

10

Small-scale

0.554

High

965880

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

8

Small-scale

0.554

High

1432525

PELI2
E3 ubiquitin-protein ligase pellino homolog 2

2

3

High-throughput

0.553

High

1432534

NPS3A
Protein NipSnap homolog 3A

1

0

High-throughput

0.549

High

856918

BAG6
Large proline-rich protein BAG6

1

14

High-throughput

0.541

High

1048203

EMX1
Homeobox protein EMX1

1

3

High-throughput

0.541

High

214936

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

6

Small-scale

0.536

High

256682

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

3

Small-scale

0.536

High

428976

RLA0
Large ribosomal subunit protein uL10

1

1

Small-scale

0.536

High

468796

HS90B
Heat shock protein HSP 90-beta

1

4

Small-scale

0.536

High

476819

RSSA
Small ribosomal subunit protein uS2

1

1

Small-scale

0.536

High

478206

SNRPA
U1 small nuclear ribonucleoprotein A

1

4

Small-scale

0.536

High

535538

BIP
Endoplasmic reticulum chaperone BiP

1

8

Small-scale

0.536

High

566454

K2C5
Keratin, type II cytoskeletal 5

1

7

Small-scale

0.536

High

568289

PLST
Plastin-3

1

3

Small-scale

0.536

High

576544

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

5

Small-scale

0.536

High

595868

H13
Histone H1.3

1

2

Small-scale

0.536

High

697654

PYR1
Multifunctional protein CAD

1

1

Small-scale

0.536

High

716972

RL12
Large ribosomal subunit protein uL11

1

1

Small-scale

0.536

High

810371

RL3
Large ribosomal subunit protein uL3

1

1

Small-scale

0.536

High

899230

TCPQ
T-complex protein 1 subunit theta

1

6

Small-scale

0.536

High

909695

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

10

Small-scale

0.536

High

935123

TERA
Transitional endoplasmic reticulum ATPase

1

1

Small-scale

0.536

High

996334

EF1A1
Elongation factor 1-alpha 1

1

3

Small-scale

0.536

High

1008645

MAP1A
Microtubule-associated protein 1A

1

4

Small-scale

0.536

High

1013867

RL24
Large ribosomal subunit protein eL24

1

1

Small-scale

0.536

High

1035536

CENPE
Centromere-associated protein E

1

2

Small-scale

0.536

High

1062644

DHX9
ATP-dependent RNA helicase A

1

7

Small-scale

0.536

High

1098134

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

2

Small-scale

0.536

High

1105658

GOGA4
Golgin subfamily A member 4

1

8

Small-scale

0.536

High

1125396

FLNC
Filamin-C

1

5

Small-scale

0.536

High

1144467

NONO
Non-POU domain-containing octamer-binding protein

1

7

Small-scale

0.536

High

1148476

SAFB1
Scaffold attachment factor B1

1

7

Small-scale

0.536

High

1160294

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

12

Small-scale

0.536

High

1293415

CARM1
Histone-arginine methyltransferase CARM1

1

6

Small-scale

0.536

High

1330622

ZN676
Zinc finger protein 676

1

3

Small-scale

0.536

High

1410589

TBA1C
Tubulin alpha-1C chain

1

7

Small-scale

0.536

High

1432526

RENT2
Regulator of nonsense transcripts 2

1

1

Small-scale

0.536

High

1432532

ZBTB4
Zinc finger and BTB domain-containing protein 4

1

9

Small-scale

0.536

High

1432540

SATB2
DNA-binding protein SATB2

1

2

Small-scale

0.534

High

1384688

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.518

High

593697

BGAL
Beta-galactosidase

1

0

High-throughput

0.513

High

824356

RL13A
Large ribosomal subunit protein uL13

1

0

Small-scale

0.513

High

1431455

S1PR5
Sphingosine 1-phosphate receptor 5

1

0

Small-scale

0.513

High

1432531

SACS
Sacsin

1

0

Small-scale

0.513

High

326372

SCAF4
SR-related and CTD-associated factor 4

1

8

Small-scale

0.508

High

179742

MDM4
Protein Mdm4

1

10

Small-scale

0.501

High

625623

CSK22
Casein kinase II subunit alpha'

1

12

Small-scale

0.501

High

861777

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

15

High-throughput

0.501

High

995263

CSK2B
Casein kinase II subunit beta

1

2

Small-scale

0.501

High

998020

CSK21
Casein kinase II subunit alpha

1

9

Small-scale

0.501

High

1126756

BECN1
Beclin-1

1

1

Small-scale

0.500

High

369750

A2MG
Alpha-2-macroglobulin

1

1

Small-scale

0.489

High

680502

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

1

Small-scale

0.489

High

876504

K2C6C
Keratin, type II cytoskeletal 6C

1

6

Small-scale

0.489

High

925751

SC24C
Protein transport protein Sec24C

1

4

Small-scale

0.489

High

391158

HEMO
Hemopexin

1

1

High-throughput

0.481

High

666910

CCNC
Cyclin-C

1

9

High-throughput

0.481

High

1272559

CSN6
COP9 signalosome complex subunit 6

1

3

High-throughput

0.481

High

138314

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

5

High-throughput

0.479

High

167192

IRF6
Interferon regulatory factor 6

1

4

Small-scale

0.479

High

167972

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

9

Small-scale

0.479

High

177945

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

10

Small-scale

0.479

High

274749

DNJB6
DnaJ homolog subfamily B member 6

1

6

High-throughput

0.479

High

326982

UBE4B
Ubiquitin conjugation factor E4 B

1

7

Small-scale

0.479

High

425629

ISG15
Ubiquitin-like protein ISG15

1

6

High-throughput

0.479

High

542651

TOP2A
DNA topoisomerase 2-alpha

1

2

Small-scale

0.479

High

587213

ITF2
Transcription factor 4

1

1

Small-scale

0.479

High

607105

CEBPB
CCAAT/enhancer-binding protein beta

1

2

Small-scale

0.479

High

659704

NFYA
Nuclear transcription factor Y subunit alpha

1

1

Small-scale

0.479

High

666767

MYL9
Myosin regulatory light polypeptide 9

1

5

High-throughput

0.479

High

675156

TNR6
Tumor necrosis factor receptor superfamily member 6

1

5

Small-scale

0.479

High

730885

1433S
14-3-3 protein sigma

1

7

Small-scale

0.479

High

761871

HSP74
Heat shock 70 kDa protein 4

1

11

Small-scale

0.479

High

799471

BRCA1
Breast cancer type 1 susceptibility protein

1

12

Small-scale

0.479

High

828250

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

6

Small-scale

0.479

High

846935

ETV4
ETS translocation variant 4

1

5

Small-scale

0.479

High

934283

BI1
Bax inhibitor 1

1

1

Small-scale

0.479

High

991427

SUMO1
Small ubiquitin-related modifier 1

1

6

Small-scale

0.479

High

1005642

PITX1
Pituitary homeobox 1

1

5

Small-scale

0.479

High

1008025

JAG1
Protein jagged-1

1

4

Small-scale

0.479

High

1045761

TF65
Transcription factor p65

1

8

Small-scale

0.479

High

1051963

KPCD
Protein kinase C delta type

1

4

Small-scale

0.479

High

1093045

CDC16
Cell division cycle protein 16 homolog

1

4

Small-scale

0.479

High

1120334

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

9

Small-scale

0.479

High

1154443

STK11
Serine/threonine-protein kinase STK11

1

2

Small-scale

0.479

High

1161392

HIF1A
Hypoxia-inducible factor 1-alpha

1

7

Small-scale

0.479

High

1178706

MTHSD
Methenyltetrahydrofolate synthase domain-containing protein

1

3

High-throughput

0.479

High

1217065

CBPC2
Cytosolic carboxypeptidase 2

1

4

High-throughput

0.479

High

1219090

DAB2P
Disabled homolog 2-interacting protein

1

4

High-throughput

0.479

High

1276040

TPC11
Trafficking protein particle complex subunit 11

1

3

High-throughput

0.479

High

1277999

R144B
E3 ubiquitin-protein ligase RNF144B

1

5

Small-scale

0.479

High

1278386

TRM11
tRNA

1

3

High-throughput

0.479

High

1316881

ASPM
Abnormal spindle-like microcephaly-associated protein

1

10

High-throughput

0.479

High

1351418

CABL1
CDK5 and ABL1 enzyme substrate 1

1

3

Small-scale

0.479

High

1364249

TOPB1
DNA topoisomerase 2-binding protein 1

1

6

Small-scale

0.479

High

1368114

HDAC2
Histone deacetylase 2

1

7

Small-scale

0.479

High

1370748

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

6

High-throughput

0.479

High

1380159

FBXW7
F-box/WD repeat-containing protein 7

1

7

Small-scale

0.479

High

1382131

MYL11
Myosin regulatory light chain 11

1

5

Small-scale

0.479

High

1394714

PIWL1
Piwi-like protein 1

1

9

High-throughput

0.479

High

1402009

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

8

Small-scale

0.479

High

1403131

CRBN
Protein cereblon

1

2

Small-scale

0.479

High

1414566

DDX23
Probable ATP-dependent RNA helicase DDX23

1

5

High-throughput

0.479

High

1419892

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

1

3

High-throughput

0.479

High

1429934

BRD8
Bromodomain-containing protein 8

1

20

High-throughput

0.479

High

1429966

RNF38
E3 ubiquitin-protein ligase RNF38

1

6

High-throughput

0.479

High

1431413

CDT1
DNA replication factor Cdt1

1

2

High-throughput

0.479

High

1432527

JPH1
Junctophilin-1

1

2

High-throughput

0.479

High

1432528

KCTD5
BTB/POZ domain-containing protein KCTD5

1

3

Small-scale

0.479

High

1432529

WWOX
WW domain-containing oxidoreductase

1

5

Small-scale

0.479

High

1432530

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

9

High-throughput

0.479

High

1432535

ANC2
Anaphase-promoting complex subunit 2

1

7

Small-scale

0.479

High

1432536

AGO2
Protein argonaute-2

1

9

High-throughput

0.479

High

1432537

AGO1
Protein argonaute-1

1

10

High-throughput

0.479

High

1432544

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

765029

CTNB1
Catenin beta-1

1

4

Small-scale

0.457

High

1091742

GNDS
Ral guanine nucleotide dissociation stimulator

1

2

Small-scale

0.457

High

127182

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.445

High

618736

ML12A
Myosin regulatory light chain 12A

1

5

Small-scale

0.445

High

881306

FAS
Fatty acid synthase

1

4

Small-scale

0.445

High

366208

HPT
Haptoglobin

1

2

High-throughput

0.439

High

353746

DRC4
Dynein regulatory complex subunit 4

1

2

High-throughput

0.437

High

548871

ADHX
Alcohol dehydrogenase class-3

1

3

High-throughput

0.437

High

1091905

NPRL3
GATOR1 complex protein NPRL3

1

3

High-throughput

0.437

High

1289195

N4BP2
NEDD4-binding protein 2

1

1

High-throughput

0.437

High

1432538

COHA1
Collagen alpha-1(XVII) chain

1

1

Small-scale

0.437

High

1432545

CEP83
Centrosomal protein of 83 kDa

1

9

High-throughput

0.437

High

289018

ERAL1
GTPase Era, mitochondrial

1

3

Small-scale

0.417

High

963540

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

1

Small-scale

0.417

High

1227447

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.407

High

389680

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.251

Low

868017

GLR
Glucagon receptor

1

0

High-throughput

0.251

Low

1128885

ITIH4
Inter-alpha-trypsin inhibitor heavy chain H4

1

0

High-throughput

0.251

Low

1432542

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.251

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025