HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: SKP2 (Q13309)
S-phase kinase-associated protein 2 (Cyclin-A/CDK2-associated protein p45) (F-box protein Skp2) (F-box/LRR-repeat protein 1) (p45skp2)
Gene: SKP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.748

Property	Details
Experiments	28514442, 33422522, 26186194, 26496610, 33961781, 32707033, 36736316
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000082 - G1/S transition of mitotic cell cycle GO:0000086 - G2/M transition of mitotic cell cycle GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 424
+	Hs
		625407 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		SKP2_HUMAN (1-424): 3e-94: 291: 100.00
+	Hs
		960089 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		SKP2_HUMAN (1-424): 3e-94: 291: 100.00
+	Hs
		960280 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		SKP2_HUMAN (1-424): 3e-94: 291: 100.00
+	Dm
		618398 CDK1_DROME (1-290): 2.24e-136: 389: 73.45		Q7YZ95_DROME (75-405): 5.44e-45: 166: 32.54
+	Dm
		618452 CDK2_DROME (1-290): 5.77e-129: 371: 55.52		Q7YZ95_DROME (75-405): 5.44e-45: 166: 32.54
+	At
		1106652 MPK6_ARATH (9-296): 3.54e-128: 371: 36.05		IMK2_ARATH (136-381): 6.63e-37: 145: 16.13