HitPredict

Interactor 1: CDK1 (P06493)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: CDK1

Interactor 2: SPDE1 (Q8NFV5)
Speedy protein E1 (Williams-Beuren syndrome chromosomal region 19 protein)
Gene: SPDYE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	15574121
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~Spy1
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 297 Hs			1 336
+	Hs
		625518 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		SPDE1_HUMAN (1-336): 0: 554: 100.00
+	Hs
		960311 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		SPDE1_HUMAN (1-336): 0: 554: 100.00
+	Xl
		724514 CDK1A_XENLA (1-296): 1.57e-141: 402: 87.50		SPD1A_XENLA (119-332): 6.46e-62: 201: 33.95
+	Xl
		621606 CDK1B_XENLA (1-296): 1.54e-140: 399: 87.16		SPD1A_XENLA (119-332): 6.46e-62: 201: 33.95
+	Hs
		625484 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		SPDYC_HUMAN (153-332): 6.24e-54: 179: 32.60
+	Hs
		625485 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		SPDYA_HUMAN (116-333): 9.7e-49: 167: 27.48
+	Hs
		414951 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		SPDYC_HUMAN (153-332): 6.24e-54: 179: 32.60
+	Hs
		414952 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		SPDYA_HUMAN (116-333): 9.7e-49: 167: 27.48
+	Hs
		960292 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		SPDYA_HUMAN (116-333): 9.7e-49: 167: 27.48
+	Hs
		960374 CDK16_HUMAN (1-297): 6.03e-124: 364: 51.68		SPDYA_HUMAN (116-333): 9.7e-49: 167: 27.48
+	Hs
		63992 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		SPDE4_HUMAN (13-110): 1.64e-23: 98.8: 57.84
+	Hs
		625476 CDK2_HUMAN (1-297): 3.26e-149: 421: 65.32		SPDE7_HUMAN (33-110): 1.34e-21: 93: 53.66
+	Hs
		64006 CDK3_HUMAN (1-289): 1.71e-144: 410: 66.78		SPDE4_HUMAN (13-110): 1.64e-23: 98.8: 57.84
+	Hs
		63987 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		SPDE4_HUMAN (13-110): 1.64e-23: 98.8: 57.84
+	Hs
		414944 CDK1_HUMAN (1-297): 2.82e-143: 406: 100.00		SPDE7_HUMAN (33-110): 1.34e-21: 93: 53.66
+	Hs
		64007 CDK5_HUMAN (1-293): 1.55e-134: 384: 56.12		SPDE4_HUMAN (13-110): 1.64e-23: 98.8: 57.84
+	Hs
		64008 CDK16_HUMAN (1-297): 6.03e-124: 364: 51.68		SPDE4_HUMAN (13-110): 1.64e-23: 98.8: 57.84